INT72757

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.23
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
colon 4
RAW 264 4
CPA 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.60 Very High Very High Very High
allodynia 1 97.32 Very High Very High Very High
Thermal hyperalgesia 2 96.76 Very High Very High Very High
nociceptor 1 95.40 Very High Very High Very High
intrathecal 1 86.28 High High
Spinal cord 2 84.68 Quite High
cINOD 16 84.04 Quite High
cva 3 81.68 Quite High
Pain 5 79.28 Quite High
diclofenac 1 79.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 97.32 Very High Very High Very High
Hyperalgesia 2 96.76 Very High Very High Very High
Hematological Disease 4 95.60 Very High Very High Very High
Colon Cancer 12 95.16 Very High Very High Very High
Aberrant Crypt Foci 2 91.00 High High
Cancer 2 86.80 High High
Nociception 2 85.16 High High
Thrombocytopenia 3 84.16 Quite High
Aplasia 2 82.72 Quite High
Hemorrhage 3 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of Negative_regulation (reduced) of iNOS in colon
1) Confidence 0.42 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.07 Pain Relevance 0.59
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of Negative_regulation (reduced) of inducible NO synthase in colon
2) Confidence 0.42 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.07 Pain Relevance 0.59
Thus, there was no correlation between decrease in iNOS activity and reduction in iNOS mRNA levels.
Negative_regulation (decrease) of Negative_regulation (reduction) of iNOS
3) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.17 Pain Relevance 0.30
Administration of the highly selective iNOS inhibitor, GW273629 ((R)-2-amino-4,4-dioxo-6(1-iminioethylamino)-4-thiahexanoic acid; 5 mg kg(-1), s.c.), 18 h after indomethacin, likewise prevented the intestinal lesions and attenuated the microvascular leakage.
Negative_regulation (prevented) of Negative_regulation (inhibitor) of iNOS
4) Confidence 0.37 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698048 Disease Relevance 0.37 Pain Relevance 0.23
I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of iNOS associated with antagonist
5) Confidence 0.35 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.69 Pain Relevance 0.93
On 9 day after CPA treatment in vivo and in vitro testing suggest a down-regulation of both cNOS and iNOS in marrow indicating that signals in addition to NO appear to be involved in the inhibitory effect of CPA on hematopoiesis.
Negative_regulation (down) of Negative_regulation (regulation) of iNOS in CPA associated with hematological disease
6) Confidence 0.28 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.40 Pain Relevance 0.04
RESULT: PFS inhibited cyclooxygenase-2 (COX-2)-catalyzed PGE(2) and inducible nitric oxide synthase (iNOS)-catalyzed NO production by lipopolysaccharide (LPS)-treated RAW 264.7 cells at 10-50 microg/ml, and these effects primarily occurred via COX-2 inhibition and iNOS down-regulation, respectively.
Negative_regulation (regulation) of Negative_regulation (down) of iNOS in RAW 264
7) Confidence 0.25 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20034551 Disease Relevance 0.23 Pain Relevance 0
RESULT: PFS inhibited cyclooxygenase-2 (COX-2)-catalyzed PGE(2) and inducible nitric oxide synthase (iNOS)-catalyzed NO production by lipopolysaccharide (LPS)-treated RAW 264.7 cells at 10-50 microg/ml, and these effects primarily occurred via COX-2 inhibition and iNOS down-regulation, respectively.
Negative_regulation (down) of Negative_regulation (regulation) of iNOS in RAW 264
8) Confidence 0.25 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20034551 Disease Relevance 0.23 Pain Relevance 0

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