INT72758

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 5.46
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
muscle 4
liver 2
proximal 2
brain 2
renal medulla 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 3 99.90 Very High Very High Very High
cINOD 33 99.56 Very High Very High Very High
medulla 5 99.44 Very High Very High Very High
acular 5 99.00 Very High Very High Very High
antagonist 6 98.64 Very High Very High Very High
dexamethasone 17 98.04 Very High Very High Very High
Inflammation 5 93.60 High High
Central nervous system 4 88.60 High High
Hippocampus 1 87.76 High High
dorsal root ganglion 10 85.92 High High
Disease Link Frequency Relevance Heat
Colorectal Cancer 9 99.84 Very High Very High Very High
INFLAMMATION 15 99.28 Very High Very High Very High
Cancer 21 99.04 Very High Very High Very High
Injury 2 91.84 High High
Eating Disorder 20 89.20 High High
Ganglion Cysts 10 85.92 High High
Convulsion 1 83.76 Quite High
Ureteral Obstruction 1 79.56 Quite High
Pain 2 78.20 Quite High
Aging 3 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.
Positive_regulation (increased) of Transcription (expression) of COX in stomach
1) Confidence 0.34 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15082878 Disease Relevance 0.05 Pain Relevance 0.04
Additional experiments showed increased COX-2 mRNA expression in the renal medulla 60 min after ketoprofen administration, that was not significantly influenced by concomitant caffeine treatment.
Positive_regulation (increased) of Transcription (expression) of COX in renal medulla associated with medulla
2) Confidence 0.29 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.05 Pain Relevance 0.33
It was shown, for example, that a 24% reduction in food intake (versus ad libitum) for 7 days results in increased mRNA expression of COX enzyme subunits in rat muscle and that activity of COX and citrate synthase are increased by 21 days [16].
Positive_regulation (results) of Transcription (expression) of COX enzyme in muscle
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667640 Disease Relevance 0.30 Pain Relevance 0
Tumours from animals treated with vehicle or celecoxib expressed significantly elevated levels of COX-2 mRNA in comparison with the adjacent normal mucosa.
Positive_regulation (elevated) of Transcription (levels) of COX associated with cancer
4) Confidence 0.27 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.06 Pain Relevance 0.47
However, COX-1SV mRNA levels were elevated in colorectal tumours and reduced after NSAID treatment to the levels observed in normal colonic mucosa.
Positive_regulation (elevated) of Transcription (levels) of COX associated with colorectal cancer and cinod
5) Confidence 0.27 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.81 Pain Relevance 0.34
Tumours from animals treated with vehicle or celecoxib expressed significantly elevated levels of COX-2 mRNA in comparison with the adjacent normal mucosa.
Positive_regulation (elevated) of Transcription (expressed) of COX associated with cancer
6) Confidence 0.27 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.07 Pain Relevance 0.47
We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.
Positive_regulation (increased) of Transcription (levels) of COX in brain
7) Confidence 0.27 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.30 Pain Relevance 0.43
It was shown, for example, that a 24% reduction in food intake (versus ad libitum) for 7 days results in increased mRNA expression of COX enzyme subunits in rat muscle and that activity of COX and citrate synthase are increased by 21 days [16].
Positive_regulation (increased) of Transcription (expression) of COX enzyme in muscle
8) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667640 Disease Relevance 0.30 Pain Relevance 0
Liver COX-2 mRNA expression significantly increased, accompanied by an increase in liver concentrations of PGE2 and TXB2, but no obvious change in 6-K-PGF1alpha concentrations.
Positive_regulation (increased) of Transcription (expression) of COX in liver
9) Confidence 0.16 Published 2007 Journal Chin. Med. J. Section Body Doc Link 18028778 Disease Relevance 0.16 Pain Relevance 0
Prolonged treatment with rofecoxib but not with ketorolac caused an upregulation of COX-2 expression while COX-1 mRNA abundance remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Transcription (abundance) of COX associated with acular
10) Confidence 0.16 Published 2002 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 12110513 Disease Relevance 0 Pain Relevance 0.38
Ibuprofen had no effect on constitutive COX (COX-1) or inducible COX (COX-2) mRNA expression.
Positive_regulation (inducible) of Transcription (expression) of COX
11) Confidence 0.09 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.09 Pain Relevance 0.14
COX-2 mRNA and protein expression was increased in the proximal dilated ureter compared to distal non-dilated ureter.
Positive_regulation (increased) of Transcription (expression) of COX in proximal
12) Confidence 0.07 Published 2006 Journal Kidney Int. Section Abstract Doc Link 16820795 Disease Relevance 0.15 Pain Relevance 0.11
Ibuprofen had no effect on constitutive COX (COX-1) or inducible COX (COX-2) mRNA expression.
Positive_regulation (inducible) of Transcription (expression) of COX
13) Confidence 0.06 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.09 Pain Relevance 0.14
Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA.
Positive_regulation (inducible) of Transcription (level) of COX associated with antagonist and dexamethasone
14) Confidence 0.05 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.38 Pain Relevance 0.83
Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA.
Positive_regulation (increased) of Transcription (level) of COX associated with antagonist and dexamethasone
15) Confidence 0.05 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.38 Pain Relevance 0.84
Currently available non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are directed at the cyclooxygenase (COX) site, but not the peroxidase (POX) activity of prostaglandin H2 synthase (PGHS).
Positive_regulation (directed) of Transcription (activity) of COX associated with aspirin, inflammation and cinod
16) Confidence 0.03 Published 2005 Journal Org. Biomol. Chem. Section Abstract Doc Link 16211102 Disease Relevance 0.19 Pain Relevance 0.25

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