INT72759

Context Info Confidence 0.39 First Reported 1997 Last Reported 2009 Negated 1 Speculated 1 Reported most in Abstract Documents 40 Total Number 42 Disease Relevance 17.26 Pain Relevance 10.00

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency stomach 6 colon 3 muscle 2 ureter 2 PGE2 2 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 15 99.44 aspirin 19 99.26 Arthritis 8 99.26 qutenza 6 99.16 acular 7 99.00 cINOD 143 98.92 antagonist 4 98.64 Inflammation 20 98.44 substance P 14 98.28 dexamethasone 15 98.04

Disease Link Frequency Relevance Heat Aging 8 99.68 Cancer 78 99.48 Colon Cancer 30 99.48 Functional Bowel Disorder 4 99.48 Colorectal Cancer 24 99.28 Arthritis 12 99.26 Urological Neuroanatomy 6 99.24 INFLAMMATION 58 98.64 Muscular Atrophy 2 98.56 Mucositis 1 98.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of the present study was to investigate a possible interaction between ketoprofen and caffeine on prostaglandin (PG) biosynthesis and cyclooxygenase (COX) mRNA expression in the rat renal medulla ex vivo.

Transcription (expression) of COX in renal medulla associated with medulla

1) Confidence 0.39 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.09 Pain Relevance 0.41

Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.

Transcription (expression) of COX in stomach

2) Confidence 0.39 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15082878 Disease Relevance 0.05 Pain Relevance 0.04

We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.

Transcription (levels) of COX in brain

3) Confidence 0.38 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.30 Pain Relevance 0.42

Treatment of rats with ketoprofen for 1 week had no significant effects on COX-2 mRNA expression.

Transcription (expression) of COX

4) Confidence 0.33 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0 Pain Relevance 0.23

Additional experiments showed increased COX-2 mRNA expression in the renal medulla 60 min after ketoprofen administration, that was not significantly influenced by concomitant caffeine treatment.

Transcription (expression) of COX in renal medulla associated with medulla

5) Confidence 0.33 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.05 Pain Relevance 0.32

The expression of COX-1 mRNA remained unchanged in all tissues examined.

Transcription (expression) of COX

6) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.83 Pain Relevance 0.38

Tumours from animals treated with vehicle or celecoxib expressed significantly elevated levels of COX-2 mRNA in comparison with the adjacent normal mucosa.

Transcription (expressed) of COX associated with cancer

7) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.07 Pain Relevance 0.47

COX-1SV mRNA represents 2% of the total COX-1 mRNA expressed and its role in colon cancer remains to be established.

Transcription (expressed) of COX in colon associated with colon cancer

8) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.74 Pain Relevance 0.32

Tumours from animals treated with vehicle or celecoxib expressed significantly elevated levels of COX-2 mRNA in comparison with the adjacent normal mucosa.

Transcription (levels) of COX associated with cancer

9) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.06 Pain Relevance 0.46

Previously, we reported that COX-1SV mRNA is differentially expressed in the ageing stomach.

Transcription (expressed) of COX in stomach associated with aging

10) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.84 Pain Relevance 0.39

We also demonstrate the presence and differential expression of COX-1SV mRNA in colon tumours.

Transcription (expression) of COX in colon associated with colon cancer

11) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.76 Pain Relevance 0.33

However, COX-1SV mRNA levels were elevated in colorectal tumours and reduced after NSAID treatment to the levels observed in normal colonic mucosa.

Transcription (levels) of COX associated with colorectal cancer and cinod

12) Confidence 0.31 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.81 Pain Relevance 0.34

Arthritis development associates with gastric COX-2 induction, mRNA and protein, and enhanced gastric prostaglandin E2 (PGE2) synthesis (P <0.01 versus control rats).

Transcription (induction) of COX in PGE2 associated with arthritis

13) Confidence 0.31 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15297470 Disease Relevance 1.39 Pain Relevance 0.81

It was shown, for example, that a 24% reduction in food intake (versus ad libitum) for 7 days results in increased mRNA expression of COX enzyme subunits in rat muscle and that activity of COX and citrate synthase are increased by 21 days [16].

Transcription (expression) of COX enzyme in muscle

14) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667640 Disease Relevance 0.30 Pain Relevance 0

In contrast, tumours from sulindac and sulindac sulfone treated rats expressed significantly less COX-2 mRNA than tumours from vehicle treated rats.

Transcription (expressed) of COX associated with cancer

15) Confidence 0.27 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.89 Pain Relevance 0.37

Protein and mRNA of COX-2 were detectable with Western blotting analysis and reverse-transcription polymerase chain reaction (RT-PCR) analysis in parathymic lymph nodes, peaking at 48 h after induction of pleurisy.

Transcription (detectable) of COX in lymph nodes associated with pleurisy

16) Confidence 0.26 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258197 Disease Relevance 0.40 Pain Relevance 0.21

COX-1 mRNA was detected by RT-PCR in the intact and melatonin-treated gastric mucosa, while COX-2 mRNA, which was undetectable in the intact gastric mucosa, appeared in WRS-exposed mucosa, especially in the melatonin-treated animals and this was accompanied by increased generation of PGE2 in gastric mucosa.

Transcription (detected) of COX in PGE2 associated with stress

17) Confidence 0.22 Published 2005 Journal J. Pineal Res. Section Abstract Doc Link 16207293 Disease Relevance 0.47 Pain Relevance 0.19

Although COX-1 mRNA was expressed in the colon without much alteration during the test period, the expression of COX-2 was upregulated with a peak on day 3 and decreased thereafter.

Neg (without) Transcription (expressed) of COX in colon

18) Confidence 0.22 Published 2006 Journal Digestion Section Abstract Doc Link 17143008 Disease Relevance 0.52 Pain Relevance 0.16

The normal gastric mucosa expressed COX-1 mRNA and not COX-2 mRNA, but COX-2 mRNA was expressed in the stomach after administration of SC-560 as well as indomethacin but not rofecoxib.

Transcription (expressed) of COX in stomach

19) Confidence 0.19 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11966529 Disease Relevance 0 Pain Relevance 0

The normal gastric mucosa expressed COX-1 mRNA and not COX-2 mRNA, but COX-2 mRNA was expressed in the stomach after administration of SC-560 as well as indomethacin but not rofecoxib.

Transcription (expressed) of COX in stomach

20) Confidence 0.19 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11966529 Disease Relevance 0 Pain Relevance 0

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