INT72760

Context Info Confidence 0.24 First Reported 1997 Last Reported 2007 Negated 5 Speculated 1 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 1.84 Pain Relevance 1.54

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency renal medulla 2 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 10 99.28 cINOD 20 97.52 Analgesic 2 94.16 Inflammation 8 93.60 Potency 4 90.08 Arthritis 1 84.84 COX2 2 25.00 cOX1 2 25.00 ischemia 7 5.00 COX-2 inhibitor 2 5.00

Disease Link Frequency Relevance Heat Cancer 8 98.72 INFLAMMATION 16 96.96 Colorectal Cancer 3 94.24 Colon Cancer 5 89.64 Disease 11 88.40 Arthritis 1 84.84 Emergencies 1 78.80 Infection 1 76.56 Aging 1 63.96 Apoptosis 1 46.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of the present study was to investigate a possible interaction between ketoprofen and caffeine on prostaglandin (PG) biosynthesis and cyclooxygenase (COX) mRNA expression in the rat renal medulla ex vivo.

Spec (possible) Regulation (interaction) of Transcription (expression) of COX in renal medulla associated with medulla

1) Confidence 0.24 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.10 Pain Relevance 0.42

Treatment of rats with ketoprofen for 1 week had no significant effects on COX-2 mRNA expression.

Neg (no) Regulation (effects) of Transcription (expression) of COX

2) Confidence 0.17 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0 Pain Relevance 0.23

The expression of COX-1 mRNA remained unchanged in all tissues examined.

Neg (unchanged) Regulation (unchanged) of Transcription (expression) of COX

3) Confidence 0.16 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.83 Pain Relevance 0.38

Ibuprofen had no effect on constitutive COX (COX-1) or inducible COX (COX-2) mRNA expression.

Neg (no) Regulation (effect) of Transcription (expression) of COX

4) Confidence 0.08 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.09 Pain Relevance 0.20

Ibuprofen had no effect on constitutive COX (COX-1) or inducible COX (COX-2) mRNA expression.

Neg (no) Regulation (effect) of Transcription (expression) of COX

5) Confidence 0.05 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406924 Disease Relevance 0.09 Pain Relevance 0.20

Of great interest is our finding that resveratrol produced a significant reduction in the expression of mPGES-1 mRNA, without modifying COX-2 mRNA expression (Figs. 3A and 3B).

Neg (without) Regulation (modifying) of Transcription (expression) of COX

6) Confidence 0.05 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0

Thus, understanding the regulation of COX isoform transcription may improve the specific inhibition of expression.

Regulation (regulation) of Transcription (transcription) of COX

7) Confidence 0.01 Published 2003 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 14552705 Disease Relevance 0.73 Pain Relevance 0.12

General Comments

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