INT72784

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 16.52
Pain Relevance 11.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
macrophages 2
granulocytes 2
leukocyte 2
lung 2
bone marrow 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1395 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
withdrawal 7 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
agonist 281 99.92 Very High Very High Very High
Dopamine 33 99.60 Very High Very High Very High
Inflammation 1160 99.32 Very High Very High Very High
antagonist 267 98.84 Very High Very High Very High
Inflammatory response 63 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 290 100.00 Very High Very High Very High
Lung Injury 264 100.00 Very High Very High Very High
INFLAMMATION 992 99.32 Very High Very High Very High
Injury 165 98.80 Very High Very High Very High
Adult Respiratory Distress Syndrome 663 98.72 Very High Very High Very High
Hypotension 9 98.20 Very High Very High Very High
Pneumonia 258 98.04 Very High Very High Very High
Increased Venous Pressure Under Development 36 97.96 Very High Very High Very High
Vibrio Infection 9 97.24 Very High Very High Very High
Catalepsy 4 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to the several-fold increase in A2AR mRNA expression levels in inflammatory granulocytes from mice exposed to 21% oxygen, these levels were up-regulated to a much lesser extent in mice breathing 100% oxygen.
Positive_regulation (increase) of A2AR mRNA in granulocytes associated with inflammation
1) Confidence 0.70 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.22 Pain Relevance 0.21
The results of mRNA expression studies were in agreement with above functional studies of adenosine receptors, and a much stronger increase in A2AR mRNA levels was observed in in vivo-activated PMNs than in naïve cells, with only small changes in A1 receptor mRNA expression in the first experiment (Figure 4C, left graph).
Positive_regulation (increase) of A2AR mRNA associated with adenocard
2) Confidence 0.70 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.07 Pain Relevance 0.16
In a genetic control, the cAMP increase was absent in in vivo-activated granulocytes from A2AR gene-deficient mice (Figure 4B, right graph).
Positive_regulation (activated) of A2AR in granulocytes
3) Confidence 0.50 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0 Pain Relevance 0.18
Modulation and measurement of cAMP production of PMNs by A2AR stimulation and antagonism in vitro
Positive_regulation (stimulation) of A2AR
4) Confidence 0.50 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0 Pain Relevance 0.12
As expected, significant up-regulation of A2AR was observed in experiments in which CGS21680 greatly enhanced the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated cAMP production of in vivo-activated neutrophils isolated from inflamed lungs from wild-type mice, but not of naïve granulocytes obtained from the bone marrow of healthy wild-type control mice (Figure 4B, left graph).
Positive_regulation (regulation) of A2AR in bone marrow
5) Confidence 0.47 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.06 Pain Relevance 0.13
In our experiments, the dose of LPS injected IT induced much higher levels of lung injury in A2AR-deficient mice than in control wild-type mice (see Figure 5), but neither wild-type or A2AR deficient mice died if they were kept at 21% oxygen at these levels of lung injury.
Neg (neither) Positive_regulation (induced) of A2AR in lung associated with lung injury
6) Confidence 0.44 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 1.28 Pain Relevance 0.26
Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice.
Positive_regulation (Enhanced) of A2A associated with targeted disruption, adenocard, narcan, opioid receptor, withdrawal and morphine
7) Confidence 0.43 Published 2004 Journal J. Neurochem. Section Title Doc Link 14756803 Disease Relevance 0.41 Pain Relevance 0.99
Moreover, in previous studies, activation of both A2A and A2B receptors on either endothelial cells or macrophages has been reported to enhance the expression of vascular endothelial growth factor and to promote angiogenesis [21,49-51].
Positive_regulation (activation) of A2A in macrophages
8) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.65 Pain Relevance 0.62
accumulation in peritoneal exudates of A2A knockout mice (Table 3).
Positive_regulation (accumulation) of A2A associated with targeted disruption
9) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.07 Pain Relevance 0.54
Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).
Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate
10) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.39 Pain Relevance 0.58
in peritoneal exudates of wild-type mice and A2A knockout mice, but significantly increased accumulation of TNF-?
Positive_regulation (accumulation) of A2A associated with targeted disruption
11) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.08 Pain Relevance 0.44
Treatment with methotrexate increased the exudate adenosine concentration in wild-type mice, A2A knockout mice and A3 knockout mice (Table 2) and reduced the leukocyte accumulation in A2A wild-type mice by 30 ± 5% (P < 0.01 vs control, n = 7; Figure 1a), but reduced the leukocyte accumulation in the A2A knockout mice by only 7 ± 5% (P = not significant vs wild-type control, n = 6; Figure 1a).
Positive_regulation (accumulation) of A2A in leukocyte associated with targeted disruption, adenocard and methotrexate
12) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.46 Pain Relevance 0.66
accumulation in A2A knockout mice.
Positive_regulation (accumulation) of A2A associated with targeted disruption
13) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.20 Pain Relevance 1.16
Activation of adenosine A2A receptors and dopamine D2 receptors produce the opposite response of increasing and decreasing the cAMP formation, respectively [31,32].
Positive_regulation (Activation) of A2A associated with dopamine and adenocard
14) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.57
Activation of A2A results in an increased adenylate cyclase activity by signaling via cholera-toxin sensitive Gs proteins.
Positive_regulation (Activation) of A2A associated with vibrio infection
15) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.46 Pain Relevance 0.21
A2A activation suppresses activation of immune cells, including T cells, monocytes, macrophages, PMNs, and dendritic cells [46].
Positive_regulation (activation) of A2A in T cells
16) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.21
Activation of A2A mediates protection from I/R injury in various tissues, including lung [48].
Positive_regulation (Activation) of A2A in lung associated with injury
17) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.68 Pain Relevance 0.25
Alveolar fluid clearance is reduced by activation of murine A1, but it is increased by A2A and A3 activation [22].
Positive_regulation (activation) of A2A
18) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.00 Pain Relevance 0.54
Alveolar fluid clearance in mice was increased upon A2A activation [22], and in a canine model of ALI pretreatment with an A2A agonist or adenosine reduced capillary filtration induced by phorbol myristate acetate [42].
Positive_regulation (activation) of A2A in capillary associated with adenocard, agonist and adult respiratory distress syndrome
19) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.10 Pain Relevance 0.38
This effect was abrogated in A2A-/- mice and in chimeric mice that expressed A2A only on non-hematopoietic cells, suggesting that A2A activation on hematopoietic cells mediates protection from pulmonary inflammation.
Positive_regulation (activation) of A2A in hematopoietic cells associated with inflammation and pneumonia
20) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.94 Pain Relevance 0.47

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