INT72798

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.84
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADA) aging (ADA) cytoplasm (ADA)
cytosol (ADA) extracellular space (ADA) cell adhesion (ADA)
Anatomy Link Frequency
poly 1
liver 1
stomach 1
kidney 1
blood cells 1
ADA (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 847 100.00 Very High Very High Very High
adenocard 9 100.00 Very High Very High Very High
rheumatoid arthritis 368 97.32 Very High Very High Very High
Pain 9 96.56 Very High Very High Very High
pruritus 5 96.32 Very High Very High Very High
Infliximab 503 93.76 High High
metalloproteinase 4 91.04 High High
Inflammation 58 85.52 High High
Multiple sclerosis 8 83.84 Quite High
cytokine 28 83.04 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 102 99.76 Very High Very High Very High
Disease 430 99.54 Very High Very High Very High
Infection 38 98.84 Very High Very High Very High
Pressure And Volume Under Development 9 97.88 Very High Very High Very High
Rheumatoid Arthritis 368 97.32 Very High Very High Very High
Obesity 47 97.32 Very High Very High Very High
Mycobacterial Infection 89 97.12 Very High Very High Very High
Pain 5 96.56 Very High Very High Very High
Pruritus 5 96.32 Very High Very High Very High
Erythema 8 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A comprehensive analysis of tolerability data from clinical trials with ADA, including 1506 patient-years of exposure in CD patients, showed that ADA was associated with a rate of 5.98 serious infections per 100-patient-years, including 0.2 cases of tuberculosis per 100 patient-years (Burmester et at 2006).
ADA Binding (associated) of associated with mycobacterial infection, adalimumab, disease and infection
1) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 1.38 Pain Relevance 0.48
Over site-injection reactions, ADA has been associated with other, rare, cutaneous side effects.
ADA Binding (associated) of associated with adalimumab
2) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 1.25 Pain Relevance 0.78
As bivalent monoclonal antibodies, each ADA molecule can bind up to two TNF-alpha molecules simultaneously, whereas a single TNF-alpha homotrimer can bind up to 3 molecules of ADA (Santora et al 2001; Scallon et al 2002).
ADA Binding (bind) of associated with adalimumab
3) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.42 Pain Relevance 0.44
As bivalent monoclonal antibodies, each ADA molecule can bind up to two TNF-alpha molecules simultaneously, whereas a single TNF-alpha homotrimer can bind up to 3 molecules of ADA (Santora et al 2001; Scallon et al 2002).
ADA Binding (bind) of associated with adalimumab
4) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.44 Pain Relevance 0.46
For example, ADA, ATP III, and USPSTF recommend both diabetes and lipid screening among patients 35–44 years old, BMI 30–<35 kg/m2, non-white, with baseline hypertension, but clinicians screened only 43% (LDL-cholesterol for females) to 83% (diabetes for males) of these patients.
ADA Binding (recommend) of associated with diabetes mellitus, hypertension and obesity
5) Confidence 0.21 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2266727 Disease Relevance 1.41 Pain Relevance 0
The current position statement of the American Diabetes Association (ADA), however, recognizes the importance of amount of dietary carbohydrates: "With regard to the glycemic effects of carbohydrates, the total amount of carbohydrate in meals or snacks is more important than the source or the type".
ADA Binding (recognizes) of associated with diabetes mellitus
6) Confidence 0.09 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 0.56 Pain Relevance 0
However, the decrease in ADA activity in blood cells may be associate with the adenosine metabolism.
ADA Binding (associate) of in blood cells associated with adenocard
7) Confidence 0.08 Published 1997 Journal Haematologia (Budap) Section Abstract Doc Link 9408766 Disease Relevance 0.50 Pain Relevance 0.53
For SMA, AMA, LKM and ADA, sera diluted 1:30 were tested on mouse stomach, kidney, liver or adrenal sections (Biomedical Diagnostics), with the same technique as described for ANA.
ADA Binding (diluted) of in stomach
8) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.15 Pain Relevance 0.19
The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating factor, liposomal doxyrubicin) to poly(ethylene) glycol.
adenosine-deaminase Binding (binding) of in poly associated with adenocard
9) Confidence 0.03 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.38 Pain Relevance 0.05
Estimation of adenosine deaminase (ADA) and IFN-?
ADA Binding (Estimation) of associated with adenocard
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856669 Disease Relevance 1.03 Pain Relevance 0.09
For SMA, AMA, LKM and ADA, sera diluted 1:30 were tested on mouse stomach, kidney, liver or adrenal sections (Biomedical Diagnostics), with the same technique as described for ANA.
ADA Binding (diluted) of in liver
11) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.15 Pain Relevance 0.19
For SMA, AMA, LKM and ADA, sera diluted 1:30 were tested on mouse stomach, kidney, liver or adrenal sections (Biomedical Diagnostics), with the same technique as described for ANA.
ADA Binding (diluted) of in kidney
12) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.15 Pain Relevance 0.19

General Comments

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