INT7280

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 97
Total Number 105
Disease Relevance 5.64
Pain Relevance 63.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
stomach 14
neurons 8
anterior pituitary 8
nerves 6
brain 4
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 748 100.00 Very High Very High Very High
Calcitonin gene-related peptide 105 100.00 Very High Very High Very High
substance P 34 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
vagus nerve 4 100.00 Very High Very High Very High
Glutamate 76 99.98 Very High Very High Very High
Morphine 33 99.98 Very High Very High Very High
noradrenaline 27 99.98 Very High Very High Very High
Hippocampus 16 99.92 Very High Very High Very High
Clonidine 35 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 25 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 9 100.00 Very High Very High Very High
Hyperinsulinism 1 100.00 Very High Very High Very High
Ganglion Cysts 12 99.84 Very High Very High Very High
Pressure And Volume Under Development 1 99.72 Very High Very High Very High
INFLAMMATION 5 99.50 Very High Very High Very High
Nociception 14 98.34 Very High Very High Very High
Cancer 1 98.24 Very High Very High Very High
Convulsion 11 98.22 Very High Very High Very High
Hyperglycemia 2 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One week after the last of three consecutive stage 5 seizures (full seizure expression) or 48 h after the last stage 2 stimulation (preconvulsive stage), 50 mM KCl-induced somatostatin release was significantly higher (1.8 +/- 0.1, P < 0.01) than in shams (animals implanted with electrodes but not stimulated) in the stimulated and contralateral hippocampus.
Positive_regulation (induced) of Localization (release) of somatostatin in stage 5 associated with convulsion, somatostatin and hippocampus
1) Confidence 0.70 Published 1992 Journal Neuroscience Section Abstract Doc Link 1361218 Disease Relevance 0.20 Pain Relevance 0.59
Somatostatin release measured under resting conditions was increased by 1.5 times in the stimulated hippocampus at stage 2 (P < 0.05) and by 2.2 and 1.7 times in both hippocampi at stage 5 (P < 0.01).
Positive_regulation (increased) of Localization (release) of Somatostatin in stage 5 associated with somatostatin and hippocampus
2) Confidence 0.70 Published 1992 Journal Neuroscience Section Abstract Doc Link 1361218 Disease Relevance 0.18 Pain Relevance 0.58
Somatostatin release is enhanced in the hippocampus of partially and fully kindled rats.
Positive_regulation (enhanced) of Localization (release) of Somatostatin in hippocampus associated with somatostatin and hippocampus
3) Confidence 0.70 Published 1992 Journal Neuroscience Section Title Doc Link 1361218 Disease Relevance 0.12 Pain Relevance 0.48
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Positive_regulation (stimulates) of Localization (release) of somatostatin in neurons associated with glutamate and somatostatin
4) Confidence 0.69 Published 1988 Journal Endocrinology Section Title Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.91
The increase in somatostatin release elicited by glutamate or NMDA was selectively antagonized by DL-2-amino-5-phosphonovaleric acid and by thyenyl-phencyclidine, two specific antagonists of NMDA receptors.
Positive_regulation (increase) of Localization (release) of somatostatin associated with glutamate, nmda receptor, antagonist and somatostatin
5) Confidence 0.69 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.97
Increasing concentrations of glutamate stimulated somatostatin release in a dose-dependent manner.
Positive_regulation (stimulated) of Localization (release) of somatostatin associated with glutamate and somatostatin
6) Confidence 0.69 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.65
Glutamate-induced somatostatin release was not blocked by tetrodotoxin (1 microM) suggesting that tetrodotoxin-sensitive sodium-dependent action potentials are not involved in this effect.
Positive_regulation (induced) of Localization (release) of somatostatin associated with action potential, tetrodotoxin, glutamate and somatostatin
7) Confidence 0.69 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 1.08
The reduction of perfusion pressure and the increase of somatostatin secretion were inhibited by concomitant administration of a CGRP antagonist.
Positive_regulation (increase) of Localization (secretion) of somatostatin associated with antagonist, somatostatin and calcitonin gene-related peptide
8) Confidence 0.67 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7904285 Disease Relevance 0 Pain Relevance 1.19
In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion.
Positive_regulation (increase) of Localization (secretion) of somatostatin in stomach associated with qutenza, somatostatin and calcitonin gene-related peptide
9) Confidence 0.67 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7904285 Disease Relevance 0 Pain Relevance 1.20
To test for a functional interaction between these two pathways, we examined the effects of cysteamine, which enhances somatostatin release for a few hours after administration but produces subsequent depletion of somatostatin lasting several days, on perforant path evoked potentials recorded in the dentate gyrus.
Positive_regulation (enhances) of Localization (release) of somatostatin in dentate gyrus associated with somatostatin
10) Confidence 0.67 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7907266 Disease Relevance 0.09 Pain Relevance 0.14
This may be the result of a diminished number of affinity of post-synaptic neurotransmitter receptors, or to an increased release of somatostatin.
Positive_regulation (increased) of Localization (release) of somatostatin associated with neurotransmitter and somatostatin
11) Confidence 0.67 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6115331 Disease Relevance 0.09 Pain Relevance 0.53
L-Glutamate, N-methyl-D-aspartic acid (NMDA), quisqualate, and kainate were found to increase endogenous somatostatin release from primary cultures of rat cortical neurons in a dose-dependent manner.
Positive_regulation (increase) of Localization (release) of somatostatin in neurons associated with glutamate and somatostatin
12) Confidence 0.67 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2570126 Disease Relevance 0 Pain Relevance 0.43
The release of somatostatin induced by the excitatory amino acid agonists was not blocked by tetrodotoxin (1 microM), a result suggesting that tetrodotoxin-sensitive, sodium-dependent action potentials are not involved in the effect.
Positive_regulation (induced) of Localization (release) of somatostatin associated with action potential, tetrodotoxin, agonist, somatostatin and excitatory amino acid
13) Confidence 0.67 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2570126 Disease Relevance 0 Pain Relevance 0.97
Effect of endogenous opioids on vagally induced release of gastrin, somatostatin and bombesin-like immunoreactivity from the perfused rat stomach.
Positive_regulation (induced) of Localization (release) of somatostatin in stomach associated with narcan, somatostatin and endogenous opioid
14) Confidence 0.66 Published 1995 Journal Regul. Pept. Section Title Doc Link 7754106 Disease Relevance 0 Pain Relevance 0.50
In the present study, we have superfused antral mucosal segments obtained from rat stomach to examine the paracrine pathways linking ANP and somatostatin secretion in this region.ANP (0.1 pM to 0.1 microM) caused a concentration-dependent increase in somatostatin secretion (EC(50), 0.3 nM).
Positive_regulation (increase) of Localization (secretion) of somatostatin in stomach associated with somatostatin
15) Confidence 0.66 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.55
The aim of the present study was to investigate how the sympathetic nervous system affects the vagally induced intragastric release of somatostatin and gastrin.
Positive_regulation (induced) of Localization (release) of somatostatin in sympathetic nervous system associated with somatostatin
16) Confidence 0.65 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1350163 Disease Relevance 0 Pain Relevance 0.22
The effects of naloxone, an opiate antagonist, on basal and vagus nerve-induced secretions of GRP, gastrin, and somatostatin were examined using the isolated perfused rat stomach prepared with vagal innervation.
Spec (examined) Positive_regulation (induced) of Spec (examined) Localization (secretions) of somatostatin in stomach associated with antagonist, somatostatin, narcan, opiate and vagus nerve
17) Confidence 0.65 Published 1987 Journal Life Sci. Section Abstract Doc Link 2889122 Disease Relevance 0 Pain Relevance 0.60
Phorbol diesters stimulate somatostatin secretion from cultured brain cells.
Positive_regulation (stimulate) of Localization (secretion) of somatostatin in brain associated with somatostatin
18) Confidence 0.64 Published 1983 Journal Endocrinology Section Title Doc Link 6407821 Disease Relevance 0.10 Pain Relevance 0.18
K+ (30 mmol/l)-induced somatostatin release was also increased (r = 0.54; P less than 0.01) by increasing doses of dopamine.
Positive_regulation (increased) of Localization (release) of somatostatin associated with dopamine and somatostatin
19) Confidence 0.61 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 0.85
K+ (30 mmol/l)-induced somatostatin release was also increased (r = 0.54; P less than 0.01) by increasing doses of dopamine.
Positive_regulation (induced) of Localization (release) of somatostatin associated with dopamine and somatostatin
20) Confidence 0.61 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 0.84

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