INT72804

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 1.79
Pain Relevance 12.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
C cells 4
amygdala 2
ovary 1
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 59 100.00 Very High Very High Very High
opioid receptor 32 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
amygdala 14 99.96 Very High Very High Very High
mu opioid receptor 20 99.80 Very High Very High Very High
Enkephalin 10 99.64 Very High Very High Very High
Hippocampus 6 99.52 Very High Very High Very High
agonist 28 99.50 Very High Very High Very High
Dynorphin 7 99.36 Very High Very High Very High
Kinase C 16 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 16 98.88 Very High Very High Very High
Cognitive Disorder 4 98.88 Very High Very High Very High
Recurrence 6 82.68 Quite High
Hyperalgesia 4 79.36 Quite High
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
Negative_regulation (inactivates) of ORL1 associated with neuroblastoma
1) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10940375 Disease Relevance 0.10 Pain Relevance 0.74
USA 103. 9715-9720), whereas repeated ethanol intake may downregulate the endogenous NC/OPRL1 system resulting in activation of ethanol consumption.
Spec (may) Negative_regulation (downregulate) of OPRL1 associated with orphanin
2) Confidence 0.43 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.08 Pain Relevance 0.65
Reduction in PNOC mRNA (1.7-fold) was found in the hippocampus of alcoholics, whereas OPRL1 mRNA levels were decreased (1.4-fold) in the central amygdala.
Negative_regulation (decreased) of OPRL1 in amygdala associated with hippocampus and amygdala
3) Confidence 0.43 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.13 Pain Relevance 0.73
The PNOC/OPRL1 downregulation may underlie impairment of cognitive control over alcohol seeking in alcoholics.
Negative_regulation (downregulation) of OPRL1 associated with cognitive disorder and alcohol
4) Confidence 0.43 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.10 Pain Relevance 0.53
Pretreatment with the mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both mu-opioid and ORL1 receptor responses. beta-Funaltrexamine (beta-FNA) pretreatment also blocked both mu-opioid and ORL1 receptor responses, but only mu-opioid receptor binding was reduced.
Negative_regulation (blocked) of ORL1 receptor associated with orphanin, agonist, enkephalin, opioid receptor and opioid
5) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.80
Pretreatment with the mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both mu-opioid and ORL1 receptor responses. beta-Funaltrexamine (beta-FNA) pretreatment also blocked both mu-opioid and ORL1 receptor responses, but only mu-opioid receptor binding was reduced.
Negative_regulation (reduced) of ORL1 receptor associated with orphanin, agonist, enkephalin, opioid receptor and opioid
6) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.80
Pretreatment with the mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both mu-opioid and ORL1 receptor responses. beta-Funaltrexamine (beta-FNA) pretreatment also blocked both mu-opioid and ORL1 receptor responses, but only mu-opioid receptor binding was reduced.
Negative_regulation (desensitized) of ORL1 receptor associated with orphanin, agonist, enkephalin, opioid receptor and opioid
7) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.82
Unlike OFQ/N-mediated desensitization of ORL1 and mu-opioid receptors, [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO)-mediated ORL1 desensitization in BE(2)-C cells is PKC-independent.
Negative_regulation (desensitization) of ORL1 in C cells associated with mu opioid receptor and enkephalin
8) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.82
This suggests that DAMGO activation of mu-opioid receptors results in GRK2 and GRK3 inactivation of ORL1 upon challenge with OFQ/N.
Negative_regulation (inactivation) of ORL1 associated with mu opioid receptor
9) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.76
Prolonged (24 h) activation of the mu receptor desensitized both mu and ORL1 receptor-mediated inhibition of forskolin-stimulated cAMP accumulation and upregulated GRK2 levels in SH-SY5Y and BE(2)-C cells.
Negative_regulation (inhibition) of ORL1 receptor in C cells
10) Confidence 0.40 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.09 Pain Relevance 0.29
We also demonstrate that chronic OFQ/N-mediated desensitization of ORL1 and mu receptors occurs via cell-specific pathways, involving ERK1/2-dependent GRK2, or PKC-dependent and ERK1/2-independent GRK3 induction.
Negative_regulation (desensitization) of ORL1 associated with kinase c
11) Confidence 0.40 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.05 Pain Relevance 0.44
Antisense DNA treatment confirmed the involvement of GRK2/3 in mu and ORL1 desensitization.
Negative_regulation (desensitization) of ORL1
12) Confidence 0.40 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.06 Pain Relevance 0.52
Protein kinase C (PKC), but not ERK1/2, inhibition blocked OFQ/N-mediated GRK3 induction and mu and ORL1 receptor desensitization in BE(2)-C cells.
Negative_regulation (desensitization) of ORL1 receptor in C cells associated with kinase c
13) Confidence 0.40 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.07 Pain Relevance 0.52
Unlike OFQ/N-mediated desensitization of ORL1 and mu-opioid receptors, [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO)-mediated ORL1 desensitization in BE(2)-C cells is PKC-independent.
Negative_regulation (desensitization) of ORL1 in C cells associated with mu opioid receptor and enkephalin
14) Confidence 0.37 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.80
Antisense, but not sense, DNA selectively targeting GRK2 or GRK3 blocks DAMGO-mediated mu- and ORL1 desensitization, respectively.
Negative_regulation (desensitization) of ORL1
15) Confidence 0.37 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.75
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Negative_regulation (reduced) of kappa receptor mRNA in amygdala associated with cannabis and amygdala
16) Confidence 0.29 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.83
Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.
Negative_regulation (inhibition) of nociceptin receptor in ovary associated with orphanin
17) Confidence 0.17 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10643813 Disease Relevance 0 Pain Relevance 0.44
In marked contrast, replacement of as few as six residues (RKLANQ) in the C-terminus of nociceptin by the corresponding dynorphin sequence (LKWDNQ) dramatically impairs both affinity and activity towards the ORL1 receptor.
Negative_regulation (impairs) of ORL1 associated with dynorphin and orphanin
18) Confidence 0.08 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9409745 Disease Relevance 0 Pain Relevance 0.91

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