INT7281

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 42
Total Number 45
Disease Relevance 5.48
Pain Relevance 26.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
brain 3
neurons 3
body 2
amygdala 1
hippocampus 1
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 308 100.00 Very High Very High Very High
Somatostatin 263 100.00 Very High Very High Very High
opioid receptor 101 100.00 Very High Very High Very High
antagonist 66 100.00 Very High Very High Very High
Enkephalin 60 100.00 Very High Very High Very High
substance P 55 100.00 Very High Very High Very High
Neuropeptide 49 100.00 Very High Very High Very High
Calcitonin gene-related peptide 23 100.00 Very High Very High Very High
opiate 16 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Immunization 4 100.00 Very High Very High Very High
Cancer 39 99.64 Very High Very High Very High
Disease 4 99.62 Very High Very High Very High
Cough 144 99.46 Very High Very High Very High
Ganglion Cysts 7 99.24 Very High Very High Very High
Cv Unclassified Under Development 4 96.60 Very High Very High Very High
Overactive Bladder 2 92.40 High High
Epilepsy 6 91.44 High High
Reprotox - General 1 20 89.20 High High
Carcinoma 1 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between somatostatin and acetylcholine, two putative transmitters in the nucleus ambiguus, was investigated on single ambigual neurons in a brainstem slice preparation.
somatostatin Binding (interaction) of in nucleus ambiguus associated with medulla and somatostatin
1) Confidence 0.48 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1674125 Disease Relevance 0 Pain Relevance 0.35
At apparent equilibrium, the specific binding of 125I-Tyr11-somatostatin was competitively inhibited by native somatostatin in the 1 nM-4 microM concentration range.
somatostatin Binding (binding) of associated with somatostatin
2) Confidence 0.48 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6149767 Disease Relevance 0 Pain Relevance 0.42
Stimulation of phosphoprotein phosphatase suggests that somatostatin may bind to the acinar cells and affect functions other than secretion and synthesis of enzymes.
somatostatin Binding (bind) of in acinar cells associated with somatostatin
3) Confidence 0.47 Published 1986 Journal Dig. Dis. Sci. Section Abstract Doc Link 2421987 Disease Relevance 0 Pain Relevance 0.47
While this octapeptide exhibited high affinity (IC50 = 2.80 nM) for an apparently single population of binding sites (nH = 0.89 +/- 0.1) and exceptional selectivity for mu opioid receptors with an IC50(DPDPE)/IC50 (naloxone) ratio of 4,829, it also displayed very low affinity for somatostatin receptors (IC50 = 22,700 nM).
somatostatin Binding (affinity) of associated with somatostatin, narcan and mu opioid receptor
4) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 2872570 Disease Relevance 0 Pain Relevance 0.50
Conformational properties of these analogs were also examined and related to their affinity for opiate and somatostatin receptors in the rat brain.
somatostatin Spec (examined) Binding (affinity) of in brain associated with somatostatin and opiate
5) Confidence 0.41 Published 1985 Journal Peptides Section Abstract Doc Link 2864680 Disease Relevance 0 Pain Relevance 0.73
Somatostatin-14 (SS-14) was applied to these neurons by superfusing solutions containing known concentrations of the peptide or by pressure ejection from micropipettes.
SS-14 Binding (applied) of in neurons associated with somatostatin
6) Confidence 0.37 Published 1989 Journal Brain Res. Section Abstract Doc Link 2573406 Disease Relevance 0 Pain Relevance 0.17
Somatostatin-14 (SS-14) was applied to these neurons by superfusing solutions containing known concentrations of the peptide or by pressure ejection from micropipettes.
Somatostatin-14 Binding (applied) of in neurons associated with somatostatin
7) Confidence 0.37 Published 1989 Journal Brain Res. Section Abstract Doc Link 2573406 Disease Relevance 0 Pain Relevance 0.17
Characterization of somatostatin binding sites in cytosolic fraction of rat intestinal mucosa.
somatostatin Binding (Characterization) of associated with somatostatin
8) Confidence 0.37 Published 1984 Journal Biochim. Biophys. Acta Section Title Doc Link 6149767 Disease Relevance 0 Pain Relevance 0.45
This study investigated whether peptides acting at somatostatin receptors, such as somatostatin-14, octreotide or cortistatin-14, can influence the extent of brain damage after focal ischaemia in rats.
somatostatin Binding (acting) of in brain associated with cv unclassified under development and somatostatin
9) Confidence 0.36 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10619179 Disease Relevance 0.25 Pain Relevance 0.25
We examined the effects of intracerebroventricular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the interactions of these neuropeptides with the selective opioid antagonists, CTAP (mu) and nor-BNI (kappa) and the mu-agonist, PL017, on body temperature (Tb) of the rat at normal ambient temperature (21 +/- 0.5 degrees C).
somatostatin Binding (interactions) of in body associated with antagonist, agonist, neuropeptide, somatostatin, opioid, cholecystokinin and intracerebroventricular
10) Confidence 0.36 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037404 Disease Relevance 0.18 Pain Relevance 0.70
Somatostatin receptors on rat anterior pituitary membranes.

[125I]Iodo-Tyr1-somatostatin (SRIF) binds with high affinity to one class of sites in the rat anterior pituitary with a KD of 0.91 +/- 0.22 nM and a receptor concentration of 104.4 +/- 1.9 fmol/mg protein.

somatostatin Binding (binds) of in anterior pituitary associated with somatostatin
11) Confidence 0.36 Published 1982 Journal Endocrinology Section Title Doc Link 6122557 Disease Relevance 0 Pain Relevance 0.70
D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) is a cyclic, penicillamine-containing octapeptide that is structurally similar to somatostatin and displays greater antagonist potency and selectivity for mu-opioid receptors, compared with the classical mu-selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2.
somatostatin Binding (compared) of associated with antagonist, mu opioid receptor, somatostatin and potency
12) Confidence 0.36 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996221 Disease Relevance 0 Pain Relevance 0.70
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
somatostatin Binding (kindling) of in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
13) Confidence 0.36 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.83
Less sequence identity exists with the mammalian opioid/nociceptin-orphanin FQ receptors (26% identity with the rat micro opioid receptor), and mammalian somatostatin receptors (25% identity with the rat somatostatin receptor type-2).
somatostatin Binding (exists) of associated with orphanin, somatostatin, opioid receptor and opioid
14) Confidence 0.36 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10694483 Disease Relevance 0 Pain Relevance 0.39
These findings corroborated our in vitro data and allow us to postulate that GABA and glutamate interact in the control of somatostatin.
somatostatin Binding (interact) of associated with glutamate, gaba and somatostatin
15) Confidence 0.36 Published 1992 Journal Endocrinology Section Abstract Doc Link 1346378 Disease Relevance 0 Pain Relevance 0.95
We examined the effects of intracerebroventricular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the interactions of these neuropeptides with the selective opioid antagonists, CTAP (mu) and nor-BNI (kappa) and the mu-agonist, PL017, on body temperature (Tb) of the rat at normal ambient temperature (21 +/- 0.5 degrees C).
SST Binding (interactions) of in body associated with antagonist, agonist, neuropeptide, somatostatin, opioid, cholecystokinin and intracerebroventricular
16) Confidence 0.36 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037404 Disease Relevance 0.18 Pain Relevance 0.70
This effect appeared to be mediated by an interaction with somatostatin receptors because cyclo-somatostatin, a somatostatin antagonist, abolished the effect of somatostatin-14.
somatostatin Spec (appeared) Binding (interaction) of associated with antagonist and somatostatin
17) Confidence 0.35 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095464 Disease Relevance 0 Pain Relevance 0.93
Our results suggest a role for pituitary and/or brain somatostatin in the physiological regulation of the intermediate pituitary lobe, and the possibility of an interaction between somatostatins and catecholamines on the regulation of intermediate lobe adenylate cyclase.
somatostatin Binding (interaction) of in pituitary associated with catecholamine and somatostatin
18) Confidence 0.35 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6138724 Disease Relevance 0 Pain Relevance 0.43
Physiological release of striatal acetylcholine (in vivo): effect of somatostatin on dopaminergic-cholinergic interaction.
somatostatin Binding (interaction) of associated with somatostatin
19) Confidence 0.33 Published 2003 Journal Brain Res. Bull. Section Title Doc Link 13679252 Disease Relevance 0 Pain Relevance 0.74
None of these tumors showed endocrine immunoactivity for gastrin, somatostatin, insulin, glucagon, and enkephalin.
somatostatin Binding (immunoactivity) of associated with cancer, somatostatin and enkephalin
20) Confidence 0.32 Published 1981 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 7240340 Disease Relevance 0.69 Pain Relevance 0.15

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