INT72812

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.20
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
macrophages 1
THP-1 1
fibroblasts 1
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 234 99.84 Very High Very High Very High
analgesia 3 97.80 Very High Very High Very High
Morphine 10 97.64 Very High Very High Very High
rheumatoid arthritis 228 93.24 High High
Pain 5 79.36 Quite High
spinal inflammation 45 74.20 Quite High
Inflammation 12 38.96 Quite Low
Osteoarthritis 24 11.32 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 1 97.12 Very High Very High Very High
Rheumatoid Arthritis 228 93.24 High High
Hepatocellular Cancer 6 91.56 High High
Pain 3 79.36 Quite High
Cancer 20 75.00 Quite High
Low Back Pain 45 74.20 Quite High
Necrosis 9 61.44 Quite High
Atherosclerotic Plaque 3 44.80 Quite Low
INFLAMMATION 15 38.96 Quite Low
Frailty 27 11.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no significant difference in absolute concentrations of M-6-G or M-3-6 nor in the ratio of M-3-G to M-6-G at peak analgesia versus relapse.
Neg (nor) Positive_regulation (concentrations) of M-6 associated with recurrence and analgesia
1) Confidence 0.49 Published 1997 Journal Cancer Invest. Section Abstract Doc Link 9412659 Disease Relevance 0.47 Pain Relevance 1.33
The role of CD147 in MMP production and cell invasion in vitro were studied through the co-culture of human CD14+ monocytes or monocytic line THP-1 cells and human fibroblasts, as well as by gel zymography and an invasion assay.
Positive_regulation (role) of CD147 in THP-1 associated with metalloproteinase
2) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 0.92 Pain Relevance 0.75
The results of our cell invasion assay confirmed the results of our gel zymography assay, which partly prove that CD147 upregulation on macrophages may increase MMP production through both autocrine and paracrine stimulation and that macrophages may act as an amplifier of the pathogenetic cascade in RA via an increase in MMP production by interacting macrophages and fibroblasts.
Positive_regulation (upregulation) of CD147 in macrophages associated with rheumatoid arthritis and metalloproteinase
3) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.40 Pain Relevance 0.34
The results of our cell invasion assay confirmed the results of our gel zymography assay, which partly prove that CD147 upregulation on macrophages may increase MMP production through both autocrine and paracrine stimulation and that macrophages may act as an amplifier of the pathogenetic cascade in RA via an increase in MMP production by interacting macrophages and fibroblasts.
Positive_regulation (upregulation) of CD147 in fibroblasts associated with rheumatoid arthritis and metalloproteinase
4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.40 Pain Relevance 0.34

General Comments

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