INT7282

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 11
Speculated 7
Reported most in Abstract
Documents 58
Total Number 65
Disease Relevance 1.92
Pain Relevance 34.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
stomach 18
neurons 8
brain 6
neural 6
vagal nerves 4
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 412 100.00 Very High Very High Very High
narcan 76 100.00 Very High Very High Very High
gABA 56 100.00 Very High Very High Very High
Enkephalin 38 100.00 Very High Very High Very High
antagonist 37 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
Dynorphin 29 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
agonist 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 100.00 Very High Very High Very High
Stress 6 100.00 Very High Very High Very High
Immunization 2 100.00 Very High Very High Very High
Ganglion Cysts 4 98.88 Very High Very High Very High
Cancer 1 95.20 Very High Very High Very High
Neuropathic Pain 5 93.12 High High
Hyperalgesia 6 92.16 High High
Convulsion 3 83.08 Quite High
Hyperinsulinism 2 77.68 Quite High
Depression 1 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that (i) the somatostatin measured is neuronally released in the striatum and (ii) microdialysis is a useful tool for examining the regulation of somatostatin release in the brain.
Spec (examining) Regulation (regulation) of Localization (release) of somatostatin in brain associated with somatostatin
1) Confidence 0.62 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.58
In separate studies, we demonstrated that perivagal treatment with the sensory neurotoxin capsaicin impaired pancreatic responses to CCK-8 but had no effect on the inhibitory action of somatostatin-14 on pancreatic secretion evoked by 2-deoxy-D-glucose, ruling out an effect of somatostatin on the vagal afferent pathway.
Neg (no) Regulation (effect) of Localization (secretion) of somatostatin associated with qutenza and somatostatin
2) Confidence 0.62 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8103634 Disease Relevance 0 Pain Relevance 0.62
The influence of membrane depolarization on somatostatin release from cerebral cortical neurons was examined.
Regulation (influence) of Localization (release) of somatostatin in neurons associated with somatostatin
3) Confidence 0.61 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120071 Disease Relevance 0 Pain Relevance 0.23
The influence of membrane depolarization on somatostatin secretion and protein synthesis by fetal and neonatal cerebrocortical neurons was studied.
Regulation (influence) of Localization (secretion) of somatostatin in neurons associated with somatostatin
4) Confidence 0.60 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.13
Gamma-aminobutyric acid-glutamate interaction in the control of somatostatin release from hypothalamic neurons in primary culture: in vivo corroboration.
Regulation (control) of Localization (release) of somatostatin in neurons associated with glutamate and somatostatin
5) Confidence 0.59 Published 1992 Journal Endocrinology Section Title Doc Link 1346378 Disease Relevance 0 Pain Relevance 0.95
These studies support the involvement of mu-opioid inhibitory receptors in the regulation of gastric somatostatin secretion.
Regulation (regulation) of Localization (secretion) of somatostatin associated with somatostatin and opioid
6) Confidence 0.59 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982463 Disease Relevance 0 Pain Relevance 0.93
Effect of endogenous opioids on vagally induced release of gastrin, somatostatin and bombesin-like immunoreactivity from the perfused rat stomach.
Regulation (Effect) of Localization (release) of somatostatin in stomach associated with narcan, somatostatin and endogenous opioid
7) Confidence 0.59 Published 1995 Journal Regul. Pept. Section Title Doc Link 7754106 Disease Relevance 0 Pain Relevance 0.50
The aim of the present study was to evaluate the effect of the opiate receptor antagonist naloxone on vagally stimulated secretion of bombesin-like immunoreactivity (BLI), somatostatin and gastrin from the isolated rat stomach, which was perfused via the celiac artery with Krebs-Ringer buffer.
Regulation (effect) of Localization (secretion) of somatostatin in celiac artery associated with antagonist, somatostatin, narcan and opiate
8) Confidence 0.59 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 7754106 Disease Relevance 0 Pain Relevance 0.39
The aim of the present study was to investigate how the sympathetic nervous system affects the vagally induced intragastric release of somatostatin and gastrin.
Regulation (affects) of Localization (release) of somatostatin in sympathetic nervous system associated with somatostatin
9) Confidence 0.58 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1350163 Disease Relevance 0 Pain Relevance 0.22
The effects of naloxone, an opiate antagonist, on basal and vagus nerve-induced secretions of GRP, gastrin, and somatostatin were examined using the isolated perfused rat stomach prepared with vagal innervation.
Regulation (effects) of Spec (examined) Localization (secretions) of somatostatin in stomach associated with antagonist, somatostatin, narcan, opiate and vagus nerve
10) Confidence 0.57 Published 1987 Journal Life Sci. Section Abstract Doc Link 2889122 Disease Relevance 0 Pain Relevance 0.60
These results suggest that dopamine and morphine act at a hypothalamic level to modulate GH release through alterations in somatostatin secretion.
Regulation (alterations) of Localization (secretion) of somatostatin associated with dopamine, somatostatin and morphine
11) Confidence 0.54 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 1.02
Effects of dopamine and morphine on immunoreactive somatostatin and LH-releasing hormone secretion from hypothalamic fragments in vitro.
Regulation (Effects) of Localization (secretion) of somatostatin associated with dopamine, somatostatin and morphine
12) Confidence 0.54 Published 1985 Journal J. Endocrinol. Section Title Doc Link 2864381 Disease Relevance 0 Pain Relevance 0.83
Since gamma-aminobutyric acid (GABA), norepinephrine, and morphine alter nociception at the level of the spinal cord, we examined whether these agents could alter the potassium-stimulated release of somatostatin from rat spinal cord slices.
Regulation (alter) of Localization (release) of somatostatin in spinal cord associated with nociception, gaba, somatostatin, spinal cord and morphine
13) Confidence 0.53 Published 1990 Journal Brain Res. Section Abstract Doc Link 1967972 Disease Relevance 0.19 Pain Relevance 0.68
Effects of various gastrointestinal peptides on gastric somatostatin release from the isolated perfused rat stomach were studied.
Regulation (Effects) of Localization (release) of somatostatin in stomach associated with somatostatin
14) Confidence 0.51 Published 1980 Journal Endocrinology Section Abstract Doc Link 7349951 Disease Relevance 0 Pain Relevance 0.26
Studies on alpha 2-adrenergic modulation of hypothalamic somatostatin secretion in rats.
Regulation (modulation) of Localization (secretion) of somatostatin associated with somatostatin
15) Confidence 0.46 Published 1993 Journal Life Sci. Section Title Doc Link 8102470 Disease Relevance 0 Pain Relevance 0.47
The effect of gamma-aminobutyric acid (GABA) on the release of somatostatin-like immunoreactivity (SRIF-LI) was studied in synaptosomes prepared from rat cerebral cortex and exposed in superfusion to the amino acid.
Regulation (effect) of Localization (release) of somatostatin in cerebral cortex associated with gaba, somatostatin and cerebral cortex
16) Confidence 0.45 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1671101 Disease Relevance 0 Pain Relevance 0.58
A control monoclonal antibody 109-21 directed against the biologically inactive glycine-extended fragment 66-72 of progastrin did not alter basal gastric acid secretion or the inhibitory effect of somatostatin.
Neg (not) Regulation (alter) of Localization (secretion) of somatostatin associated with somatostatin
17) Confidence 0.44 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.05 Pain Relevance 0.41
Divergent effects of acute depolarization on somatostatin release and protein synthesis in cultured fetal and neonatal rat brain cells.
Regulation (effects) of Localization (release) of somatostatin in brain associated with somatostatin
18) Confidence 0.44 Published 1989 Journal J. Neurochem. Section Title Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.29
Naloxone had no effect on vagal or GRP-induced regulation of gastrin and somatostatin release.
Regulation (regulation) of Localization (release) of somatostatin associated with somatostatin and narcan
19) Confidence 0.43 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 7754106 Disease Relevance 0 Pain Relevance 0.41
The effects of local infusion of a 16 mM K+ solution or of a nociceptive stress on the release of somatostatin (SRIF) from the hypothalamus was measured in unanesthetized male rats implanted with a push-pull cannula in the median eminence.
Regulation (effects) of Localization (release) of somatostatin in hypothalamus associated with stress, nociception and somatostatin
20) Confidence 0.43 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6149508 Disease Relevance 0.43 Pain Relevance 0.25

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