INT72822

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.48
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
forebrain 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 34 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Opioid 3 98.08 Very High Very High Very High
corticosteroid 2 88.16 High High
cytokine 23 53.76 Quite High
epidural 4 50.00 Quite Low
tail-flick 8 49.40 Quite Low
Analgesic 5 32.76 Quite Low
Enkephalin 1 25.00 Low Low
bradykinin 5 15.52 Low Low
Disease Link Frequency Relevance Heat
Stress 69 100.00 Very High Very High Very High
Aggression 2 100.00 Very High Very High Very High
Anxiety Disorder 116 94.76 High High
Occupational Lung Diseases 2 94.36 High High
Disease 6 84.08 Quite High
Appetite Loss 1 78.96 Quite High
Targeted Disruption 9 70.56 Quite High
Nociception 6 58.44 Quite High
Post-partum Hemorrhage 1 56.32 Quite High
Asthma 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin.
Negative_regulation (Reduced) of Gene_expression (expression) of oxytocin
1) Confidence 0.41 Published 2003 Journal Neuroscience Section Title Doc Link 14580937 Disease Relevance 0.22 Pain Relevance 0.27
A significant rise of prolactin was observed after 20 minutes in all women, but after 10 minutes in mothers having received oxytocin infusion during labor.
Negative_regulation (received) of Gene_expression (infusion) of oxytocin
2) Confidence 0.35 Published 2009 Journal Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Section Body Doc Link 19210132 Disease Relevance 0.06 Pain Relevance 0
Multivariable linear regression was used to determine whether oxytocin levels differed between the two groups after correcting for potential confounders.
Spec (whether) Negative_regulation (differed) of Spec (whether) Gene_expression (levels) of oxytocin
3) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.26 Pain Relevance 0.07
Of particular interest, we found that the expression level of the neuropeptide oxytocin, which is known to mediate emotional behaviors such as social recognition [26], aggression [27] and stress-induced analgesia [24], was decreased in CaMKIV-/- mice by more than twofold (2.83 fold, P < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of oxytocin associated with stress, aggression, neuropeptide and analgesia
4) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.97 Pain Relevance 0.34
Since oxytocin has been shown to mediate stress-induced analgesia in mice [24] and our gene expression analysis showed that the basal expression of oxytocin is reduced after the deletion of CaMKIV, this result is consistent with the lack of stress induced analgesia in CaMKIV-/- mice.


Negative_regulation (reduced) of Gene_expression (expression) of oxytocin associated with stress and analgesia
5) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.91 Pain Relevance 0.44
A significant negative relationship was found between oxytocin and ACTH levels, but not between oxytocin and cortisol levels.
Neg (not) Negative_regulation (between) of Neg (not) Gene_expression (levels) of oxytocin
6) Confidence 0.07 Published 2009 Journal Breastfeed Med Section Body Doc Link 19731998 Disease Relevance 0 Pain Relevance 0
This study, the first using the pig, examined expression of mRNAs for vasopressin (VP), oxytocin (OT), preproenkephalin (PENK) and pro-opiomelanocortin (POMC) in the forebrain, and of POMC and prolactin in the pituitary.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of oxytocin in forebrain
7) Confidence 0.03 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9413019 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox