INT72842

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 0.58
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
plasma 1
neurons 1
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 393 100.00 Very High Very High Very High
Kinase C 315 99.84 Very High Very High Very High
opioid receptor 2 99.36 Very High Very High Very High
MU agonist 1 97.96 Very High Very High Very High
addiction 1 91.48 High High
adenocard 180 78.24 Quite High
Action potential 8 77.12 Quite High
Opioid 1 76.64 Quite High
Glutamate receptor 12 74.88 Quite High
Delta opioid receptors 1 70.52 Quite High
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 48 79.72 Quite High
Neuroblastoma 14 75.00 Quite High
Glioma 5 75.00 Quite High
Anaplastic Astrocytoma 9 72.32 Quite High
Obesity 12 45.44 Quite Low
Cancer 33 34.72 Quite Low
Necrosis 3 34.16 Quite Low
Disease 18 5.00 Very Low Very Low Very Low
Hypoxia 15 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2-adrenergic receptors (Chuang et al. 1995), and more recently phosphorylation of GRK2 by PKC was shown to suppress its inhibition by CaM (Krasel et al. 2001).
Phosphorylation (phosphorylation) of GRK2 associated with kinase c
1) Confidence 0.47 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0.07 Pain Relevance 0.35
However, in relation to the latter, PKC has previously been shown to phosphorylate GRK2 resulting in enhanced desensitization of ?
Phosphorylation (phosphorylate) of GRK2 associated with kinase c
2) Confidence 0.47 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0.07 Pain Relevance 0.40
q/11), suggest that the phosphorylation-dependent activity of endogenous GRK2 is required for M1 mACh receptor desensitization in synaptically-active hippocampal neurons (Willets et al. 2005).
Phosphorylation (phosphorylation) of GRK2 in neurons
3) Confidence 0.46 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.28
Whether independent/permissive phosphorylations of the M1 receptor by PKCs and GRK2 occur, or whether a synergistic modulation of GRK activity by PKC results in such regulation remains to be established.
Phosphorylation (phosphorylations) of GRK2 associated with kinase c
4) Confidence 0.46 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0.08 Pain Relevance 0.39
Finally, highly purified recombinant betaARK1 proved active to phosphorylate enriched delta-opioid receptor preparations in an opioid agonist-dependent manner.
Phosphorylation (phosphorylate) of betaARK1 associated with mu agonist and opioid receptor
5) Confidence 0.31 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9413931 Disease Relevance 0.29 Pain Relevance 0.34
Palmer et al. and Ferguson et al. failed to demonstrate GRK-2 phosphorylation of A1R; in the latter study it was found that nonphosphorylated A1R redistributes arrestin 3 from the cytoplasm into punctate clusters at the plasma membrane [37, 47].
Phosphorylation (phosphorylation) of GRK-2 in plasma
6) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.07
Peters et al. studied the role of phosphorylation by PKA and PKC rather than GRK2 in agonist-induced desensitization in COS-7 cells transiently expressing the 5?
Phosphorylation (phosphorylation) of GRK2 associated with agonist
7) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.07 Pain Relevance 0.17
The role of GRK2 in agonist-induced phosphorylation and subsequent desensitization of A2AR and A2BR was thoroughly investigated by Kelly and co-workers.
Phosphorylation (phosphorylation) of GRK2 associated with agonist
8) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox