INT72864

Context Info Confidence 0.68 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 7.46 Pain Relevance 1.14

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele) cellular_component (Sele)

Anatomy Link Frequency endothelial cells 4 Lungs 4 vascular endothelium 2 neutrophils 2 Sele (Rattus norvegicus)

Pain Link Frequency Relevance Heat Angina 7 99.28 antagonist 1 96.60 Inflammation 106 88.88 Inflammatory response 6 87.88 cytokine 21 83.44 Analgesic 1 82.20 Inflammatory mediators 10 75.00 spinal inflammation 1 61.60 ketamine 3 5.00 corticosteroid 2 5.00

Disease Link Frequency Relevance Heat Adhesions 26 100.00 Hypersensitivity 172 99.60 Necrosis 6 99.48 Atherosclerosis 19 99.38 Cancer 5 99.30 Angina 4 99.28 Brain Injury 2 98.96 Overdose 1 98.36 Disease 10 95.16 Uveitis 9 93.08

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Furthermore, AECA positive sera from patients, with or without coronary atherosclerosis displayed similar capacity of inducing E-selectin expression by endothelial cells.

Positive_regulation (inducing) of Gene_expression (expression) of E-selectin in endothelial cells associated with atherosclerosis

1) Confidence 0.68 Published 2000 Journal Immunol. Lett. Section Abstract Doc Link 10963807 Disease Relevance 0.90 Pain Relevance 0.11

AECA positive sera were further evaluated for its ability to promote in vitro E-selectin expression by HUVEC using a cell-based ELISA.

Positive_regulation (promote) of Gene_expression (expression) of E-selectin

2) Confidence 0.46 Published 2000 Journal Immunol. Lett. Section Abstract Doc Link 10963807 Disease Relevance 0.88 Pain Relevance 0.13

In addition, an increased E-selectin expression in lungs was also found.

Positive_regulation (increased) of Gene_expression (expression) of E-selectin in lungs

3) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.23 Pain Relevance 0.12

Lungs of OVx allergic rats significantly increased the E-selectin expression, an effect prevented by estradiol but not by progesterone treatment.

Positive_regulation (increased) of Gene_expression (expression) of E-selectin in Lungs associated with hypersensitivity

4) Confidence 0.45 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2936382 Disease Relevance 0.86 Pain Relevance 0.11

Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.

Positive_regulation (increased) of Gene_expression (expressions) of E-selectin associated with antagonist and overdose

5) Confidence 0.44 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.90 Pain Relevance 0.19

Ischemic brain tissue expresses chemotactic proteins like MCP-1 [19] and microvascular endothelial cells significantly upregulate the expression of ICAM 1, vascular adhesion molecule-1 (VCAM) and E-selectin following acute ischemic cerebral injury as reported by Zhang et al. [35] and Blann et al. [4].

Positive_regulation (upregulate) of Gene_expression (expression) of E-selectin in endothelial cells associated with brain injury and adhesions

6) Confidence 0.06 Published 2005 Journal GMS German Medical Science Section Body Doc Link PMC2703252 Disease Relevance 0.44 Pain Relevance 0

Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina.

Positive_regulation (circulation) of Gene_expression (levels) of E-selectin associated with angina

7) Confidence 0.04 Published 1997 Journal Cardiovasc. Res. Section Title Doc Link 9415270 Disease Relevance 0.38 Pain Relevance 0.19

Levels of soluble E-selectin were elevated in the diabetic patients in comparison with the non-diabetic patients at all measured time points: 74 +/- 10 ng/ml vs. 47 +/- 3 ng/ml, P < 0.03 at t = 0 h, 55 +/- 5 ng/ml vs. 38 +/- 2 ng/ml, P < 0.02 at t = 72 h.

Positive_regulation (elevated) of Gene_expression (Levels) of E-selectin

8) Confidence 0.03 Published 2001 Journal Diabet. Med. Section Body Doc Link 11903397 Disease Relevance 0.24 Pain Relevance 0

In addition, we observed increased levels of E-selectin that may reflect higher endothelial cell activation, as an increased expression of adhesion molecules is known to reflect activation of the vascular endothelium [26].

Positive_regulation (increased) of Gene_expression (levels) of E-selectin in vascular endothelium associated with adhesions

9) Confidence 0.02 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.71 Pain Relevance 0.12

The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e.

Positive_regulation (induced) of Gene_expression (expression) of E-selectin in neutrophils associated with necrosis, cancer and adhesions

10) Confidence 0.02 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.92 Pain Relevance 0.17

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