INT72868

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
A431 1
SK-N-SH 1
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.42 Very High Very High Very High
opioid receptor 1 98.22 Very High Very High Very High
addiction 4 98.00 Very High Very High Very High
Opioid 8 97.44 Very High Very High Very High
Kinase C 2 94.36 High High
agonist 4 82.96 Quite High
gABA 1 82.60 Quite High
adenocard 3 50.84 Quite High
Clonidine 1 25.00 Low Low
Calcium channel 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Carcinoma 1 99.26 Very High Very High Very High
Neuroblastoma 4 99.10 Very High Very High Very High
Drug Dependence 1 98.20 Very High Very High Very High
Shock 3 92.88 High High
Opiate Addiction 3 75.00 Quite High
Pituitary Cancer 1 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells were maintained in primary culture and they consistently expressed mRNA coding for adenylyl cyclase I, III, VI, VII and IX.
Transcription (expressed) of cyclase
1) Confidence 0.57 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.05
In SK-N-SH human neuroblastoma cells, morphine significantly increased RNA transcript and protein levels of type I adenylate cyclase, leading to sensitization.
Transcription (transcript) of type I adenylate cyclase in SK-N-SH associated with neuroblastoma and morphine
2) Confidence 0.27 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100459 Disease Relevance 0.35 Pain Relevance 0.55
Chronic opioid treatment of stably mu-opioid receptor transfected human mammary epidermoid A431 carcinoma cells (clone A431/mu 13) results in sensitization of adenylyl cyclase (AC), a cellular adaptation associated with drug dependence.
Transcription (sensitization) of cyclase in A431 associated with drug dependence, addiction, carcinoma, opioid receptor and opioid
3) Confidence 0.14 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415709 Disease Relevance 0.27 Pain Relevance 0.38
Interestingly HEK293 cells express mRNA for numerous isoforms of adenylyl cyclase and protein kinases A and C (PRKA, PRKC) and phospholipase C (PLC), while having a limited diversity of phospholipase A (PLA) and RGS proteins.
Transcription (express) of adenylyl cyclase
4) Confidence 0.01 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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