INT72869

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.70
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 6 98.52 Very High Very High Very High
addiction 4 75.00 Quite High
Morphine 1 71.68 Quite High
opioid receptor 1 50.76 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 9 100.00 Very High Very High Very High
Colorectal Cancer 95 98.32 Very High Very High Very High
Cancer 50 93.52 High High
Adenoma 9 89.04 High High
Adenocarcinoma 2 88.16 High High
Opiate Addiction 3 75.00 Quite High
Apoptosis 3 72.12 Quite High
Aberrant Crypt Foci 1 60.84 Quite High
Drug Dependence 1 58.04 Quite High
Colon Cancer 9 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, both chemical depalmitoylation by hydroxylamine and inhibition of palmitoyl-CoA transferase in vivo by tunicamycin treatment incresed the reconstitutive activity of detergent extracts and eliminated the differences between native and opioid-dependent cells, indicating that the increase in stimulatory activity is due to depalmitoylation of Gs alpha.
Regulation (due) of Negative_regulation (depalmitoylation) of Gs alpha associated with opioid
1) Confidence 0.36 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415709 Disease Relevance 0.26 Pain Relevance 0.54
Inactivation of the APC protein is responsible for both inherited and sporadic types of CRC.
Regulation (responsible) of Negative_regulation (Inactivation) of APC associated with colorectal cancer and familial adenomatous polyposis
2) Confidence 0.23 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.44 Pain Relevance 0

General Comments

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