INT72878

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.47
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
amygdala 1
crf (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 8 100.00 Very High Very High Very High
medulla 27 89.80 High High
Thalamus 2 87.40 High High
Nicotine 2 78.84 Quite High
cocaine 3 77.92 Quite High
cINOD 1 77.12 Quite High
Nucleus accumbens 5 66.16 Quite High
agonist 10 65.04 Quite High
Dopamine 1 57.92 Quite High
Somatostatin 4 41.16 Quite Low
Disease Link Frequency Relevance Heat
Fatigue 216 100.00 Very High Very High Very High
Chronic Renal Failure 9 100.00 Very High Very High Very High
Stress 4 99.64 Very High Very High Very High
Immunotherapy Of Cancer 16 98.52 Very High Very High Very High
Renal Disease 7 98.40 Very High Very High Very High
Reprotox - General 1 2 96.72 Very High Very High Very High
Breast Cancer 64 96.36 Very High Very High Very High
Premature Menopause 8 95.56 Very High Very High Very High
Polycystic Kidney Disease 1 95.40 Very High Very High Very High
Toxicity 2 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cause of CRF was unknown in 16.2% of the cases.
Positive_regulation (cause) of CRF associated with chronic renal failure
1) Confidence 0.26 Published 1997 Journal Ren Fail Section Abstract Doc Link 9415933 Disease Relevance 1.76 Pain Relevance 0.08
CRF could be mediated by the endocrine sequelae of breast cancer treatment, including the induction of amenorrhea, the induction of premature menopause due to ovarian toxicity caused by chemotherapy, radiotherapy and the side effects of adjuvant endocrine treatment [17].
Positive_regulation (mediated) of CRF associated with toxicity, premature menopause, fatigue, reprotox - general 1 and immunotherapy of cancer
2) Confidence 0.18 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2939549 Disease Relevance 2.74 Pain Relevance 0
CRF should be screened and evaluated according to clinical guidelines to provide patients with an accurate consultation and appropriate management.
Positive_regulation (evaluated) of CRF associated with fatigue
3) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2939549 Disease Relevance 1.43 Pain Relevance 0
The release of CRF and bombesin-like peptides in the amygdala is markedly increased by both stress and feeding [179].
Positive_regulation (increased) of CRF in amygdala associated with stress and amygdala
4) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.56
The second class was the facilitatory ERF, which showed continuously increasing neuronal response even as the stimulus size increased beyond the CRF (arrow in Figure 1D).
Positive_regulation (increased) of CRF in neuronal
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994074 Disease Relevance 0 Pain Relevance 0
We then measured the CRF diameter by performing an occlusion test [4], [28], in which a mask of circular blank patch, concentric with the CRF, was gradually increased in size on a background drifting grating.
Positive_regulation (increased) of CRF
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994074 Disease Relevance 0 Pain Relevance 0

General Comments

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