INT72884

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 14.01
Pain Relevance 7.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
body 2
blood 1
nerve 1
plaques 1
brain 1
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 246 100.00 Very High Very High Very High
Morphine 6 99.98 Very High Very High Very High
Inflammation 11 99.90 Very High Very High Very High
painful pain 27 99.80 Very High Very High Very High
Pain 332 99.16 Very High Very High Very High
tolerance 12 96.08 Very High Very High Very High
reflex sympathetic dystrophy 25 94.72 High High
Eae 7 94.40 High High
Sciatic nerve 2 93.32 High High
Gabapentin 3 91.92 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 342 100.00 Very High Very High Very High
Neurogenic Inflammation 4 99.90 Very High Very High Very High
Nociception 42 99.80 Very High Very High Very High
Syndrome 34 99.60 Very High Very High Very High
Nervous System Injury 4 99.40 Very High Very High Very High
Pain 412 99.16 Very High Very High Very High
Targeted Disruption 83 98.96 Very High Very High Very High
Disease 214 98.74 Very High Very High Very High
Body Weight 66 98.28 Very High Very High Very High
Impaired Glucose Tolerance 12 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fasting blood glucose levels under basal conditions were significantly elevated in one-year old NEP-deficient mice (Figure 3d).
Positive_regulation (elevated) of NEP in blood
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.84 Pain Relevance 0.05
As described for wild-type animals before, increasing leptin levels in NEP-deficient mice correlated with increasing body weight [9], [21] (Figure 3c).
Positive_regulation (increasing) of NEP in body associated with body weight
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 1.12 Pain Relevance 0
Since the pharmacological increase in NEP might be difficult, the identification of orexigenic peptides (and their receptors) influenced by NEP activity may be a promising targeted approach to reduce body weight for the treatment of obesity.


Positive_regulation (increase) of NEP in body associated with body weight and obesity
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.34 Pain Relevance 0
The incompletely glycosylated intracellular sNEP showed no enzymatic activity, consistent with reports that glycosylation is required for NEP activity [46].
Positive_regulation (required) of NEP
4) Confidence 0.38 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
When considering the above mentioned NeP and NocP syndromes, the LANSS Pain Scale was able to correctly identify 82,4% (810/983) of patients with one pain complaint, representing 84,7% sensitivity and 80,2% specificity.


Positive_regulation (mentioned) of NeP associated with pain, syndrome, neuropathic pain and painful pain
5) Confidence 0.38 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.75 Pain Relevance 1.62
However, a major hurdle in establishing a correct diagnosis and hence to provide the patient with the appropriate therapy is the lack of unambiguous diagnostic criteria for distinguishing NeP from NocP.
Positive_regulation (distinguishing) of NeP associated with neuropathic pain and painful pain
6) Confidence 0.38 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 2.31 Pain Relevance 2.35
Treatment of NeP in Belgian routine practice
Positive_regulation (Treatment) of NeP associated with neuropathic pain
7) Confidence 0.33 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 1.66 Pain Relevance 1.77
The results provide evidence that pain behavior and neurogenic inflammation are enhanced in NEP ko mice after nerve injury.
Positive_regulation (enhanced) of NEP in nerve associated with pain, nervous system injury, inflammation and neurogenic inflammation
8) Confidence 0.28 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19084065 Disease Relevance 1.67 Pain Relevance 1.07
As an approach to elevate NEP levels and improve the enzyme's access to extracellular A?
Positive_regulation (elevate) of NEP
9) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 1.19 Pain Relevance 0.13
However, a recent study using elderly AD transgenic mice that had already developed plaques found that increased NEP levels did not reduce existing plaques (Mohajeri et al 2004).
Positive_regulation (increased) of NEP in plaques associated with targeted disruption and disease
10) Confidence 0.17 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.92 Pain Relevance 0
Along with IDE, NEP is an important A?
Positive_regulation (important) of NEP
11) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0.04
Repaglinide showed additive effects when used in combination with other oral antidiabetic agents including metformin, troglitazone, rosiglitazone and pioglitazone, and intermediate-acting insulin (NPH) given at bedtime.
Positive_regulation (intermediate-acting) of NPH
12) Confidence 0.10 Published 2001 Journal Drugs Section Abstract Doc Link 11577798 Disease Relevance 0.77 Pain Relevance 0.08
While the CSR peptides themselves may offer a potential target in the struggle to prevent abnormal protein aggregation in the brain, our results suggest that simply increasing IDE and NEP activity may not be as beneficial as anticipated.
Positive_regulation (increasing) of NEP in brain
13) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.35 Pain Relevance 0
Lipopolysaccharide (10 microg/animal) stimulated the processing of ACTH (1-39) yielding ACTH (1-24) in a cleavage that is independent of NEP, but dependent on aspartyl proteases, demonstrating differential enzymatic cleavage of ACTH (1-39).
Neg (independent) Positive_regulation (independent) of NEP in cleavage
14) Confidence 0.02 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878818 Disease Relevance 0 Pain Relevance 0.33
In conclusion, morphine increased NEP activities and thus attenuated shedding of L-selectin and ICAM-1.
Positive_regulation (increased) of NEP associated with morphine
15) Confidence 0.02 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.07 Pain Relevance 0.23

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