INT72890

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 1997
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.81
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T-cell 4
marginal zone 2
mast cells 2
respiratory 2
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 65 99.80 Very High Very High Very High
Inflammation 113 98.84 Very High Very High Very High
endometriosis 9 96.28 Very High Very High Very High
diclofenac 24 94.80 High High
anesthesia 5 94.16 High High
Freund adjuvant 12 93.12 High High
Hyperalgesia 1 89.96 High High
Pain 1 89.28 High High
pain pelvic 2 76.20 Quite High
Antihistamine 3 72.96 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 55 99.98 Very High Very High Very High
Immunization 26 99.88 Very High Very High Very High
Sprains And Strains 42 99.64 Very High Very High Very High
Pressure And Volume Under Development 6 99.24 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
INFLAMMATION 124 98.84 Very High Very High Very High
Genetic Predisposition To Disease 2 97.46 Very High Very High Very High
Endometriosis 10 96.28 Very High Very High Very High
Hypertrophy 1 93.24 High High
Hyperplasia 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alternative hypothesis is that the route of administration, dose of allergen inhaled (or ingested), and genetic predisposition are the principal factors that affect allergen recognition and development of allergen-specific TH2 responses that ultimately lead to IgE production.
Positive_regulation (lead) of Gene_expression (production) of IgE associated with genetic predisposition to disease
1) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.41 Pain Relevance 0.04
Why do allergens induce IgE responses?
Positive_regulation (induce) of Gene_expression (responses) of IgE
2) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.35 Pain Relevance 0.03
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of Neg (negative) Gene_expression (negative) of CD23 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
3) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0
The respiratory allergen trimellitic anhydride (TMA) has been shown to induce IgE production and immediate ear swelling in mice sensitized to it.
Positive_regulation (induce) of Gene_expression (production) of IgE in respiratory associated with pressure and volume under development
4) Confidence 0.09 Published 1997 Journal J Appl Toxicol Section Abstract Doc Link 9418942 Disease Relevance 0.33 Pain Relevance 0.17
Th2 cytokine IL-4 and IgE production were significant increased 5 days after last challenge while IFN-gamma level was below the detection limit.
Positive_regulation (increased) of Gene_expression (production) of IgE associated with cytokine
5) Confidence 0.09 Published 2007 Journal Scand. J. Immunol. Section Abstract Doc Link 17257216 Disease Relevance 0.45 Pain Relevance 0.22
DNA vaccination with plasmid encoding Der p 5, one of the minor HDM allergens, was reported to prevent induction of specific IgE synthesis [11].
Positive_regulation (induction) of Gene_expression (synthesis) of IgE
6) Confidence 0.07 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.80 Pain Relevance 0.06
The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high-affinity IgE receptor-mediated mast cell inflammatory sequelae.
Positive_regulation (required) of Gene_expression (expression) of IgE in mast cells associated with inflammation
7) Confidence 0.05 Published 2007 Journal Am. J. Reprod. Immunol. Section Abstract Doc Link 17631002 Disease Relevance 2.30 Pain Relevance 0.96
Downregulation of allergen specific IgE production by DNA vaccination
Positive_regulation (specific) of Gene_expression (production) of IgE
8) Confidence 0.05 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.19 Pain Relevance 0.03
Determining total IgE, HDM-specific IgE, and HDM-specific IgG
Positive_regulation (total) of Gene_expression (Determining) of IgE
9) Confidence 0.05 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.51 Pain Relevance 0.26
Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (induces) of Gene_expression (production) of IgE in T-cell associated with diclofenac
10) Confidence 0.04 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.26
Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (mediated) of Gene_expression (production) of IgE in T-cell associated with diclofenac
11) Confidence 0.04 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.23
As shown in Figure 2, the response patterns for BALB/cA and NIH mice were similar to those shown in Figure 1, with increased IgE production in both strains, whereas IgG2a production was increased only in NIH mice.
Positive_regulation (increased) of Gene_expression (production) of IgE associated with sprains and strains
12) Confidence 0.02 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox