INT7290

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 7.28
Pain Relevance 16.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
striatum 8
nucleus accumbens 8
brain 4
forebrain 4
anterior 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 96 100.00 Very High Very High Very High
dopamine receptor 13 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
midbrain 4 100.00 Very High Very High Very High
fortral 16 99.98 Very High Very High Very High
Deafferentation 4 99.98 Very High Very High Very High
antagonist 27 99.96 Very High Very High Very High
agonist 27 99.96 Very High Very High Very High
Hippocampus 32 99.88 Very High Very High Very High
Dopamine 24 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 34 99.88 Very High Very High Very High
Convulsion 20 99.52 Very High Very High Very High
Death 3 98.98 Very High Very High Very High
Stress 14 98.08 Very High Very High Very High
Hyperalgesia 6 97.12 Very High Very High Very High
Body Weight 6 95.48 Very High Very High Very High
Muscle Rigidity 3 95.36 Very High Very High Very High
Catalepsy 14 94.68 High High
Parkinson's Disease 10 93.68 High High
Pheochromocytoma 1 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPEP administered systemically and mGluR1 antagonists (AIDA, CPCCOEt, LY367385) injected intrastriatally reversed also the haloperidol-increased proenkephalin (PENK) mRNA expression in the striatopallidal pathway.
Negative_regulation (reversed) of Transcription (expression) of PENK associated with antagonist
1) Confidence 0.59 Published 2007 Journal Amino Acids Section Abstract Doc Link 16699817 Disease Relevance 0.70 Pain Relevance 0.32
As cortical or thalamic deafferentation decreases striatal PENK mRNA expression [40,41], we identified potential afferents regulating striatal hnPENK in this study by performing correlations between extrastriatal, regional IEG expression and striatal, regional hnPENK expression (Figure 7C).
Negative_regulation (decreases) of Transcription (expression) of PENK associated with deafferentation
2) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.35
Cortical or thalamic deafferentation selectively decreases striatal PENK mRNA expression [40,41].
Negative_regulation (decreases) of Transcription (expression) of PENK associated with deafferentation
3) Confidence 0.58 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.63
Antagonism of D1 receptor activity with SCH-23390 significantly decreased proenkephalin mRNA abundance in all brain regions.
Negative_regulation (decreased) of Transcription (abundance) of proenkephalin in brain
4) Confidence 0.57 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1346626 Disease Relevance 0 Pain Relevance 0.43
SCH 58261, a selective adenosine A2A receptor antagonist, decreases the haloperidol-enhanced proenkephalin mRNA expression in the rat striatum.
Negative_regulation (decreases) of Transcription (expression) of proenkephalin in striatum associated with adenocard, antagonist and enkephalin
5) Confidence 0.43 Published 2003 Journal Brain Res. Section Title Doc Link 12834887 Disease Relevance 0.66 Pain Relevance 0.59
THC exposure reduced preproenkephalin (PENK) mRNA expression in the nucleus accumbens during early development, but was elevated in adulthood; no adult striatal changes on preprodynorphin mRNA or PENK in caudate-putamen.
Negative_regulation (reduced) of Transcription (expression) of PENK in nucleus accumbens
6) Confidence 0.43 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 16876136 Disease Relevance 0 Pain Relevance 0
MPEP administered systemically and mGluR1 antagonists (AIDA, CPCCOEt, LY367385) injected intrastriatally reversed also the haloperidol-increased proenkephalin (PENK) mRNA expression in the striatopallidal pathway.
Negative_regulation (reversed) of Transcription (expression) of proenkephalin associated with antagonist
7) Confidence 0.43 Published 2007 Journal Amino Acids Section Abstract Doc Link 16699817 Disease Relevance 0.70 Pain Relevance 0.32
The ISH studies revealed a decrease in mRNA expression of Enk and SP in the striatum and NAC.
Negative_regulation (decrease) of Transcription (expression) of Enk in NAC associated with nucleus accumbens, enkephalin and substance p
8) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885430 Disease Relevance 0.61 Pain Relevance 1.42
Chronic treatment with SKF 10047 decreased proenkephalin mRNA levels in the anterior aspect of the caudate-putamen (CPU) and the nucleus accumbens by 20-22% relative to controls.
Negative_regulation (decreased) of Transcription (levels) of proenkephalin in caudate-putamen associated with nucleus accumbens
9) Confidence 0.42 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1647506 Disease Relevance 0 Pain Relevance 0.43
Chronic treatment with pentazocine or SFK 10047 decrease proenkephalin mRNA levels in the rat striatum and nucleus accumbens.
Negative_regulation (decrease) of Transcription (levels) of proenkephalin in striatum associated with nucleus accumbens, fortral and enkephalin
10) Confidence 0.42 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1647506 Disease Relevance 0 Pain Relevance 0.73
D2 blockade with haloperidol or raclopride increased, whereas D2 stimulation with LY-171555 (D2 agonist) decreased, striatal and accumbens proenkephalin mRNA abundance.
Negative_regulation (decreased) of Transcription (abundance) of proenkephalin associated with agonist
11) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1346626 Disease Relevance 0 Pain Relevance 0.39
Furthermore, in virgin rats, allopregnanolone treatment increased, whereas in pregnant rats finasteride decreased proenkephalin-A mRNA expression in the NTS.
Negative_regulation (decreased) of Transcription (expression) of proenkephalin-A
12) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19458216 Disease Relevance 0.07 Pain Relevance 0.69
The data demonstrate that acute treatment with dopaminergic D2 agonists and antagonists affects proenkephalin mRNA abundance in the striatum and accumbens via a D2 receptor mechanism, consistent with the concept that D2 receptor function inhibits the synthesis of the mRNA encoding the enkephalin peptides.
Negative_regulation (inhibits) of Transcription (synthesis) of enkephalin in striatum associated with antagonist, agonist and enkephalin
13) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1346626 Disease Relevance 0 Pain Relevance 0.46
In situ hybridization study showed that single imipramine injection (10 mg/kg, i.p.) decreased the level of proenkephalin (by ca. 20%) and prodynorphin (by ca. 25%) mRNA to the same extent in both structures.
Negative_regulation (decreased) of Transcription (level) of proenkephalin
14) Confidence 0.41 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.33
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (content) of proenkephalin A in gland
15) Confidence 0.41 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
The cellular localization of proenkephalin (PE) mRNA expression was systematically examined in midsagittal (vermal) sections of the developing rat cerebellar cortex by in situ hybridization.
Negative_regulation (localization) of Transcription (expression) of proenkephalin in cerebellar cortex
16) Confidence 0.41 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1790599 Disease Relevance 0 Pain Relevance 0
Inactivation of cAMP dependent-protein kinase (PKA) with a dominant inhibitory mutant strongly reduced PACAP-stimulated PENK transcription.
Negative_regulation (reduced) of Transcription (transcription) of PENK
17) Confidence 0.40 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0
Restricting food intake suppressed mRNA levels of proDyn, proEnk, and POMC by 29.7, 22.3, and 44.4%, respectively, in 20% restricted rats and by 35.5, 26.8, and 45.6%, respectively, in 40%restricted rats (P < 0.01).
Negative_regulation (suppressed) of Transcription (levels) of proEnk
18) Confidence 0.40 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.61 Pain Relevance 0.27
After hemitransection severing neuronal connections between the ventral midbrain regions and the forebrain structures, fibers with NT-LI and those with Enk-LI in the ventral midbrain regions were markedly reduced in number.
Negative_regulation (reduced) of Transcription (hemitransection) of Enk in midbrain associated with enkephalin and midbrain
19) Confidence 0.39 Published 1987 Journal J. Comp. Neurol. Section Abstract Doc Link 2435769 Disease Relevance 0 Pain Relevance 1.59
The decreased level of preproenkephalin mRNA in the nucleus accumbens may reflect a neuroadaptive response to increased release of dopamine, whereas the increased level of preproenkephalin mRNA in the central nucleus of the amygdala may be associated with an anxiolytic effect of ethanol consumption.
Negative_regulation (decreased) of Transcription (level) of preproenkephalin in amygdala
20) Confidence 0.39 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505043 Disease Relevance 0 Pain Relevance 0

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