INT72917

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (Crh, Crhr1) signal transduction (Crhr1) extracellular space (Crh)
extracellular region (Crh) plasma membrane (Crhr1) signal transducer activity (Crhr1)
Crh (Mus musculus)
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 4 98.96 Very High Very High Very High
antagonist 4 92.08 High High
Hippocampus 1 90.64 High High
Spinal cord 8 88.56 High High
Nucleus accumbens 1 87.92 High High
amygdala 51 86.40 High High
Neurotransmitter 4 82.64 Quite High
Neuropeptide 2 82.16 Quite High
Kinase C 1 72.84 Quite High
gABA 24 62.68 Quite High
Disease Link Frequency Relevance Heat
Stress 13 99.48 Very High Very High Very High
Edema 2 75.00 Quite High
Increased Venous Pressure Under Development 4 73.36 Quite High
Depression 1 41.04 Quite Low
Alcohol Addiction 8 29.68 Quite Low
Anxiety Disorder 5 24.08 Low Low
Eczema 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Psoriasis 1 5.00 Very Low Very Low Very Low
Urticaria 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF Binding (binds) of CRF receptor 1
1) Confidence 0.32 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.18 Pain Relevance 0.15
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF Binding (binds) of CRF1
2) Confidence 0.32 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.18 Pain Relevance 0.15
A switch in coupling from AC9 to AC7 results in a more robust cAMP signal when CRF binds to CRF1 (Antoni, 2000; Antoni et al., 2003).
CRF Binding (binds) of CRF1
3) Confidence 0.16 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.30
The free acid analog of CRH, which does not interact with its receptors (CRHR), had no biological activity.
CRH Neg (not) Binding (interact) of CRHR
4) Confidence 0.08 Published 1998 Journal Endocrinology Section Abstract Doc Link 9421440 Disease Relevance 0.37 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox