INT72923

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 72
Total Number 81
Disease Relevance 99.19
Pain Relevance 30.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MCRS1) protein modification process (MCRS1) nucleolus (MCRS1)
nucleus (MCRS1) cytoplasm (MCRS1)
Anatomy Link Frequency
brain 8
blood 4
spikes 2
cerebrospinal fluid 2
liver 1
MCRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 7744 100.00 Very High Very High Very High
imagery 220 99.84 Very High Very High Very High
ketamine 13 99.76 Very High Very High Very High
Inflammation 291 99.72 Very High Very High Very High
Somatosensory cortex 3 99.64 Very High Very High Very High
ischemia 83 99.20 Very High Very High Very High
Sumatriptan 12 98.90 Very High Very High Very High
lidocaine 7 98.64 Very High Very High Very High
cytokine 417 98.52 Very High Very High Very High
Calcium channel 18 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6488 100.00 Very High Very High Very High
Pressure And Volume Under Development 315 100.00 Very High Very High Very High
Intracranial Hypertension 309 100.00 Very High Very High Very High
Head Trauma 71 99.90 Very High Very High Very High
Neurogenic Diabetes Insipidus 28 99.74 Very High Very High Very High
INFLAMMATION 297 99.72 Very High Very High Very High
Death 431 99.68 Very High Very High Very High
Brain Injury 2724 99.56 Very High Very High Very High
Altitude Sickness 312 99.56 Very High Very High Very High
Cancer 30 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, they and recently another group [70] oppositely report a positive correlation with mean AMS scores, concluding that ICP increases are a major factor in AMS pathophysiology.
Positive_regulation (increases) of ICP associated with altitude sickness and cva
1) Confidence 0.50 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 0.85 Pain Relevance 0.25
Similar to the MRI studies on brain volume, we found no relationship of the increase in ICP to the incidence or severity of mild-mod AMS symptoms.
Positive_regulation (increase) of ICP in brain associated with altitude sickness and cva
2) Confidence 0.44 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 1.84 Pain Relevance 0.36
The extreme form of AMS, high altitude cerebral edema (HACE), is associated with increased ICP.
Positive_regulation (increased) of ICP associated with altitude sickness and cva
3) Confidence 0.44 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 2.31 Pain Relevance 0.48
The ROC curve for this data set using ICP>15 mm Hg as the cutoff denoting elevated ICP, indicates a relative accuracy of 0.89 (area under curve; 95% CI is 0.73-1.05) to predict raised ICP (Figure 1B).
Positive_regulation (elevated) of ICP associated with cva
4) Confidence 0.44 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 0.91 Pain Relevance 0.26
The instantaneous predicted absolute intracranial pressure (ICP, mmHg) is derived from: 1) a linear transformation of the applied force (gms) into the resultant change in intraocular tension (IOT, mm Hg) by using a published nomogram [18] that incorporates a correction for the resting (baseline) intraocular pressure and 2) a second simple conversion of the IOT (at the VOP) into the predicted ICP based on the calibrated patient data.
Positive_regulation (derived) of ICP associated with cva and ocular hypertension
5) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 0.60 Pain Relevance 0.18
In a single case with an implanted telemetric ICP monitor at 5030 m, ICP increased to upper normal levels at rest and further still with exertion [32].
Positive_regulation (increased) of ICP in upper associated with cva
6) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 1.31 Pain Relevance 0.22
Increases in ICP directly affect the collapsible and valveless venous system draining the orbit into the cavernous sinus.
Positive_regulation (Increases) of ICP in venous system associated with cva
7) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 0.66 Pain Relevance 0.17
Physiologic increases in ICP and mild-mod AMS are separate responses to high altitude, possibly reflecting swelling and vasoactive instability, respectively.



Positive_regulation (increases) of ICP associated with pressure and volume under development, altitude sickness and cva
8) Confidence 0.29 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC2987855 Disease Relevance 1.08 Pain Relevance 0.33
With increased ICP or decreased CPP, StcO2 is reduced.
Positive_regulation (increased) of ICP associated with cva
9) Confidence 0.25 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.57 Pain Relevance 0.54
As well, increased ICP or decreased CPP are associated with a reduction in BIS.
Positive_regulation (increased) of ICP associated with cva
10) Confidence 0.25 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.57
The paradoxical finding of decreased LoS with proximity to specialized cardiology center while we find an increased LoS with ICP and an increased likelihood of ICP with proximity can be explained by the interaction between ICP and proximity to cardiology center in the evaluation of LoS.
Positive_regulation (increased) of ICP
11) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.08 Pain Relevance 0
As seen in Table 2, the interaction term included in the LoS model show that, for patients with ICP, the LoS is lower for patients near a cardiology center than for those farther, whereas, for patients not receiving ICP, those that are closer have not a lower LoS than the others.
Neg (not) Positive_regulation (receiving) of ICP
12) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.20 Pain Relevance 0
We also observed gender variations in ICP rates, HD rates and LoS.
Positive_regulation (variations) of ICP associated with death
13) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.25 Pain Relevance 0
An important finding of this study is the inverse relationship between ICP and HD, the inverse relationship between ICP and EHR, the increase of LoS with ICP, the positive relationship between the distance to a specialized cardiology center and EHR as well as LoS, and the negative relationship between the distance to a specialized cardiology center and ICP.
Positive_regulation (increase) of ICP associated with death
14) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.16 Pain Relevance 0
The paradoxical finding of decreased LoS with proximity to specialized cardiology center while we find an increased LoS with ICP and an increased likelihood of ICP with proximity can be explained by the interaction between ICP and proximity to cardiology center in the evaluation of LoS.
Positive_regulation (increased) of ICP
15) Confidence 0.21 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.08 Pain Relevance 0
An increasing CAP Index indicates a modest reduction in MAP and substantial increase in ICP (Table 6).
Positive_regulation (increase) of ICP associated with cva
16) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.84 Pain Relevance 0.38
The intraorbital part of the sheath, and particularly its retrobulbar segment, can distend when ICP (and hence cerebrospinal fluid [CSF] pressure) is elevated.
Positive_regulation (elevated) of ICP in cerebrospinal fluid associated with cva
17) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.31 Pain Relevance 0.69
An elevated CAP Index indicates a modest reduction in MAP and substantial increase in ICP.
Positive_regulation (increase) of ICP associated with cva
18) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.47 Pain Relevance 0.57
The size and location of intracerebral hemorrhage could explain why even a moderate increase in left-hemispheric ICP may have caused transtentorial brain herniation in our patient and did not increase right-hemispheric ICP first.
Positive_regulation (increase) of ICP in brain associated with cva and cerebral haemorrage
19) Confidence 0.11 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936928 Disease Relevance 1.33 Pain Relevance 0.57
Considering experimental study results [11,12], it must be assumed that placement of the intraparenchymal pressure probe on the ipsilateral side of the lesion would have allowed detection of locally elevated ICP in our patient.
Positive_regulation (elevated) of ICP associated with cva
20) Confidence 0.11 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936928 Disease Relevance 1.12 Pain Relevance 0.49

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