INT72924

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Context Info
Confidence 0.19
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 33.59
Pain Relevance 10.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MCRS1) protein modification process (MCRS1) nucleolus (MCRS1)
nucleus (MCRS1) cytoplasm (MCRS1)
Anatomy Link Frequency
blood 2
brain 2
cerebrospinal fluid 1
Cranial 1
MCRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2269 100.00 Very High Very High Very High
ketamine 39 99.98 Very High Very High Very High
anticonvulsant 12 99.68 Very High Very High Very High
Pain 22 99.66 Very High Very High Very High
imagery 136 98.92 Very High Very High Very High
addiction 1 97.40 Very High Very High Very High
alcohol 10 96.96 Very High Very High Very High
Sumatriptan 2 93.20 High High
tolerance 1 91.84 High High
dexamethasone 8 88.32 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1720 100.00 Very High Very High Very High
Injury 260 100.00 Very High Very High Very High
Intracranial Hypertension 132 100.00 Very High Very High Very High
Brain Injury 464 99.84 Very High Very High Very High
Pain 13 99.66 Very High Very High Very High
Sleep Disorders 236 99.40 Very High Very High Very High
Hypothermia 25 99.38 Very High Very High Very High
Stroke 85 98.00 Very High Very High Very High
Epilepsy 36 97.84 Very High Very High Very High
Thrombosis Related Under Development 130 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased distance to a specialized cardiology center was associated with a decreased likelihood of ICP, a decrease in LoS, but an increased likelihood of EHR.


Negative_regulation (decrease) of ICP
1) Confidence 0.19 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1181243 Disease Relevance 0.79 Pain Relevance 0.07
An ICP rate in Quebec of 43.7% was much lower for women than for men (p < 0.0001), and decreased with age, whereas the hospital LoS showed an opposite trend.
Negative_regulation (decreased) of ICP
2) Confidence 0.19 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.33 Pain Relevance 0
ICP was continuously measured in TBI patients via an intraparenchymal probe (Codman & Shurlett Inc., Ryanham, MA, USA) inserted into the frontal lobe via Technicam Cranial Access® device (Technicam Ltd, Newton Abbot, UK) by a neurosurgeon.
Negative_regulation (measured) of ICP in Cranial associated with cva and brain injury
3) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.22 Pain Relevance 0.59
An increasing CAP Index indicates a modest reduction in MAP and substantial increase in ICP (Table 6).
Negative_regulation (reduction) of ICP associated with cva
4) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.90 Pain Relevance 0.40
Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Negative_regulation (decreased) of ICP associated with cva
5) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.13 Pain Relevance 0.54
ICP and CPP monitoring are limited by non-distinct targets and need for expertise with monitor insertion.
Negative_regulation (limited) of ICP associated with cva
6) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.20 Pain Relevance 0.40
Good neurological outcome patients also have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Negative_regulation (decreased) of ICP associated with cva
7) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.26 Pain Relevance 0.60
As well, increased ICP or decreased CPP are associated with a reduction in BIS.
Negative_regulation (decreased) of ICP associated with cva
8) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.57
Additional investigations may prove that a marginal ICP in blunt trauma patients with intracranial hemorrhage and GCS score 3 to 8 does not need to be lowered with BIS ?
Negative_regulation (lowered) of ICP associated with injury and cva
9) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.79 Pain Relevance 0.52
The ICP measured was initially 17 mmHg, but rapidly decreased with adequate sedation using a continuous propofol infusion and repeated fentanyl injections.
Negative_regulation (decreased) of ICP associated with cva and sleep disorders
10) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936928 Disease Relevance 1.57 Pain Relevance 0.35
Laser therapy of PSNVM might not be necessary once the ICP is lowered.


Negative_regulation (lowered) of ICP
11) Confidence 0.04 Published 2005 Journal Klin Monbl Augenheilkd Section Body Doc Link 15786000 Disease Relevance 0.06 Pain Relevance 0
Although no prophylactic treatment is currently available to prevent elevated ICP, neurointensivists and neurosurgeons often use sedatives, mannitol, hypertonic saline, cerebrospinal fluid drainage, decompressive craniectomy, and/or barbiturate-induced coma to manage this condition.
Negative_regulation (prevent) of ICP in cerebrospinal fluid associated with cva and coma
12) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.58 Pain Relevance 0.46
Interestingly, the group of TBI patients who subsequently developed ICP ?
Negative_regulation (developed) of ICP associated with cva and brain injury
13) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.54 Pain Relevance 0.25
Elevated ICP was defined as a ?
Negative_regulation (defined) of ICP associated with cva
14) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.38 Pain Relevance 0.35
If barbiturates can lower ICP and provide neuroprotection even without EBS, then why has an association with good outcomes not been realized in clinical trials [10]?
Negative_regulation (lower) of ICP associated with cva
15) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592754 Disease Relevance 0.77 Pain Relevance 0.23
Hypothetically, a moderate constriction of precapillary resistance vessels might be advantageous since it decreases intracapillary blood pressure, and a contraction of cerebral veins might effectively reduce intracranial blood volume and ICP.
Spec (might) Negative_regulation (reduce) of ICP in blood associated with cva
16) Confidence 0.03 Published 1997 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9422289 Disease Relevance 0.37 Pain Relevance 0.35
The ICP is not low and DPE is not observed on Gd-MRI.
Neg (not) Negative_regulation (low) of ICP
17) Confidence 0.03 Published 2007 Journal Eur. J. Med. Res. Section Body Doc Link 17666314 Disease Relevance 0 Pain Relevance 0
Unilateral or bilateral decompressive craniotomy (DC) showed additional benefits for all these patients reducing ICP and increasing CPP.
Negative_regulation (reducing) of ICP associated with cva
18) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350130 Disease Relevance 0.82 Pain Relevance 0.10
After decompressive craniotomy in cases of uncontrollable intracranial hypertension, brain tissue oxygen tension had also increased along with decreased ICP in the patients examined by several other authors (Unterberg et al 1995).
Negative_regulation (decreased) of ICP in brain associated with cva
19) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350130 Disease Relevance 1.21 Pain Relevance 0.38
Postoperatively, all these patients experienced immediate decreases in ICP to levels at or below 20 mmHg (presentation mean ICP, 35.2 mmHg; postoperative mean ICP, 15.2 mmHg) and postoperative CPP improvements from at least 22.5 mmHg.
Negative_regulation (decreases) of ICP associated with cva
20) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350130 Disease Relevance 1.45 Pain Relevance 0.26

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