INT72944

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PCSK1) extracellular space (PCSK1) small molecule metabolic process (PCSK1)
Golgi apparatus (PCSK1) embryo development (PCSK1) cellular nitrogen compound metabolic process (PCSK1)
Anatomy Link Frequency
knee 1
PCSK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 18 98.94 Very High Very High Very High
Enkephalin 4 67.44 Quite High
Osteoarthritis 14 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Knee Osteoarthritis 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neuromuscular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PC2 cleaved proDyn to produce dynorphin (Dyn) A 1-17, Dyn B 1-13, and alpha-neo-endorphin, without a previous requirement for PC1/PC3.
Neg (without) Positive_regulation (requirement) of PC1 associated with dynorphin
1) Confidence 0.49 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9422738 Disease Relevance 0 Pain Relevance 0.45
For the multivariate model with log MTPM at 1 year using the same 4 factors, only PC1 of the knee adduction moment and BMI remained significant in the model (implant group: p = 0.1; BMI: p = 0.04; PC1 knee adduction moment: p = 0.09; PC1 knee flexion moment: p = 0.33).
Positive_regulation (only) of PC1 in knee
2) Confidence 0.37 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
PC2 cleaved proDyn to produce dynorphin (Dyn) A 1-17, Dyn B 1-13, and alpha-neo-endorphin, without a previous requirement for PC1/PC3.
Neg (without) Positive_regulation (requirement) of PC3 associated with dynorphin
3) Confidence 0.21 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9422738 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox