INT72947

Context Info Confidence 0.42 First Reported 1997 Last Reported 2010 Negated 4 Speculated 1 Reported most in Body Documents 9 Total Number 10 Disease Relevance 5.86 Pain Relevance 0.06

Anatomy Link Frequency monocytes 2 fibroblasts 2 CHM (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 55.72 Migraine 2 50.00 imagery 25 5.00 cytokine 24 5.00 anesthesia 7 5.00 cva 6 5.00 chemokine 4 5.00 cerebral cortex 3 5.00 Pain 3 5.00 Congenital analgesia 1 5.00

Disease Link Frequency Relevance Heat Choroideremia 665 100.00 Disease 118 98.32 Toxicity 12 96.68 Retina Disease 8 95.40 Sleep Disorders 10 95.32 Mitral Valve Insufficiency 4 95.20 Age-related Macular Degeneration 16 94.24 Patent Foramen Ovale 2 89.80 Hypertension 4 78.80 Dyslipidemia / Combined Dyslipidemia 4 77.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.

CHM Neg (not) Binding (recognized) of in monocytes associated with choroideremia

1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0

Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.

CHM Neg (not) Binding (recognized) of in monocytes associated with choroideremia

2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.89 Pain Relevance 0

In contrast, TCD has greater specificity but is associated with a lower sensitivity, with 17% false negative results.

TCD Binding (associated) of

3) Confidence 0.28 Published 1997 Journal J. Vasc. Surg. Section Body Doc Link 9423712 Disease Relevance 0 Pain Relevance 0

All patients underwent standard TTE, TCD, and TEE examination.

TCD Spec (examination) Binding (underwent) of

4) Confidence 0.25 Published 2009 Journal Echocardiography Section Body Doc Link 19452605 Disease Relevance 0.09 Pain Relevance 0

Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.

CHM Neg (not) Binding (recognized) of in fibroblasts associated with choroideremia

5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0

Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.

CHM Neg (not) Binding (recognized) of in fibroblasts associated with choroideremia

6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.89 Pain Relevance 0

TCD recordings

TCD Binding (recordings) of

7) Confidence 0.10 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.10 Pain Relevance 0

Specifically, Rab7 disease mutants L129F and V162M and the constitutively active mutant Q67L showed increased interaction with Vps13C and ORP1L, whereas only the disease mutants showed increased interaction with clathrin heavy chain, and all constructs interacted equally with REP-1 (Fig. 4C).

REP-1 Binding (interacted) of associated with disease

8) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.57 Pain Relevance 0

We have documented this case because it describes an interesting example of TCD and TEE interaction.

TCD Binding (interaction) of

9) Confidence 0.05 Published 2008 Journal Cases J Section Body Doc Link PMC2542348 Disease Relevance 0.68 Pain Relevance 0.03

We have documented this case because it describes an interesting example of TCD and TEE interaction.

TCD Binding (example) of

10) Confidence 0.04 Published 2008 Journal Cases J Section Body Doc Link PMC2542348 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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