INT72947

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.86
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 2
fibroblasts 2
CHM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 55.72 Quite High
Migraine 2 50.00 Quite Low
imagery 25 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Congenital analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 665 100.00 Very High Very High Very High
Disease 118 98.32 Very High Very High Very High
Toxicity 12 96.68 Very High Very High Very High
Retina Disease 8 95.40 Very High Very High Very High
Sleep Disorders 10 95.32 Very High Very High Very High
Mitral Valve Insufficiency 4 95.20 Very High Very High Very High
Age-related Macular Degeneration 16 94.24 High High
Patent Foramen Ovale 2 89.80 High High
Hypertension 4 78.80 Quite High
Dyslipidemia /

Combined Dyslipidemia

4 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.


CHM Neg (not) Binding (recognized) of in monocytes associated with choroideremia
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0
Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.


CHM Neg (not) Binding (recognized) of in monocytes associated with choroideremia
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.89 Pain Relevance 0
In contrast, TCD has greater specificity but is associated with a lower sensitivity, with 17% false negative results.
TCD Binding (associated) of
3) Confidence 0.28 Published 1997 Journal J. Vasc. Surg. Section Body Doc Link 9423712 Disease Relevance 0 Pain Relevance 0
All patients underwent standard TTE, TCD, and TEE examination.
TCD Spec (examination) Binding (underwent) of
4) Confidence 0.25 Published 2009 Journal Echocardiography Section Body Doc Link 19452605 Disease Relevance 0.09 Pain Relevance 0
Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.


CHM Neg (not) Binding (recognized) of in fibroblasts associated with choroideremia
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0
Possibly the disordered cell function observed in fibroblasts and monocytes from CHM patients represents a subclinical CHM phenotype that was not previously recognized and offers the opportunity for further research.


CHM Neg (not) Binding (recognized) of in fibroblasts associated with choroideremia
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.89 Pain Relevance 0
TCD recordings
TCD Binding (recordings) of
7) Confidence 0.10 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.10 Pain Relevance 0
Specifically, Rab7 disease mutants L129F and V162M and the constitutively active mutant Q67L showed increased interaction with Vps13C and ORP1L, whereas only the disease mutants showed increased interaction with clathrin heavy chain, and all constructs interacted equally with REP-1 (Fig. 4C).
REP-1 Binding (interacted) of associated with disease
8) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.57 Pain Relevance 0
We have documented this case because it describes an interesting example of TCD and TEE interaction.


TCD Binding (interaction) of
9) Confidence 0.05 Published 2008 Journal Cases J Section Body Doc Link PMC2542348 Disease Relevance 0.68 Pain Relevance 0.03
We have documented this case because it describes an interesting example of TCD and TEE interaction.


TCD Binding (example) of
10) Confidence 0.04 Published 2008 Journal Cases J Section Body Doc Link PMC2542348 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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