INT72949

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Context Info
Confidence 0.46
First Reported 1997
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 31
Total Number 37
Disease Relevance 23.12
Pain Relevance 11.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 15
macrophage 3
neurons 1
urothelial cell 1
T cells 1
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 855 100.00 Very High Very High Very High
chemokine 399 99.80 Very High Very High Very High
substance P 44 99.76 Very High Very High Very High
qutenza 6 99.38 Very High Very High Very High
cytokine 164 99.28 Very High Very High Very High
Neurotransmitter 6 99.28 Very High Very High Very High
pain pelvic 1 99.00 Very High Very High Very High
corticosteroid 12 97.76 Very High Very High Very High
spinal inflammation 14 95.84 Very High Very High Very High
ischemia 134 93.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 892 100.00 Very High Very High Very High
Cystitis 373 99.84 Very High Very High Very High
Reprotox - General 3 1 99.00 Very High Very High Very High
Injury 194 98.68 Very High Very High Very High
Syndrome 1 98.52 Very High Very High Very High
Bladder Cancer 63 97.96 Very High Very High Very High
Colon Cancer 22 97.68 Very High Very High Very High
Disease 81 97.24 Very High Very High Very High
Inflammatory Bowel Disease 21 96.40 Very High Very High Very High
Low Back Pain 17 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we hypothesized that CXCR4-MIF complex formation may also occur in the bladder (as described occurring in vitro [18]).
MIF Binding (formation) of in bladder
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.29
We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis.


MIF Binding (associations) of in bladder associated with cystitis
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.45 Pain Relevance 0.22
Similarly, at 18.00 hr the interaction of MIF and NAL was not explained by antagonism of progesterone.
MIF Binding (interaction) of
3) Confidence 0.43 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9423931 Disease Relevance 0 Pain Relevance 0.19
These findings suggest that in association with other proteins MIF forms part of a complex elicited by bladder inflammation.


MIF Binding (association) of in bladder
4) Confidence 0.42 Published 2005 Journal J. Urol. Section Body Doc Link 15947686 Disease Relevance 0 Pain Relevance 0
Using dual immunohistochemistry we show that MIF and CXCR4 are colocalized within the same cells in the urothelium and co-immunoprecipitation studies demonstrate MIF-CXCR4 associations in the bladder.
MIF Binding (associations) of in bladder
5) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.12
Finally, changes in prostate MIF content after intravesical LPS suggest that MIF may be involved in viscerovisceral interactions associated with chronic pelvic pain syndromes.
MIF Binding (interactions) of associated with syndrome and pain pelvic
6) Confidence 0.37 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.74 Pain Relevance 0.44
Mass spectrometry determined that MIF was complexed with acute phase proteins.
MIF Spec (determined) Binding (complexed) of
7) Confidence 0.36 Published 2005 Journal J. Urol. Section Body Doc Link 15947686 Disease Relevance 0 Pain Relevance 0
Co-immunoprecipitation studies with CXCR4 antisera to “pull-down” CXCR4 protein complexes in bladder homogenates were followed by MIF Western-blotting in order to detect CXCR4-MIF complexes in bladder homogenates.
MIF Binding (complexes) of in bladder
8) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
MIF Binding (association) of in bladder associated with inflammation, cystitis and cytokine
9) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.81 Pain Relevance 0.21
Therefore, luminal MIF may contribute to bladder inflammation through binding to at least these two urothelial cell-surface receptors and suggests that blocking MIF or cell-surface receptors associated with MIF may prevent or ameliorate bladder inflammation.
MIF Binding (binding) of in urothelial cell associated with inflammation
10) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.27
Recently, however, a novel functional association between MIF and chemokine receptors CXCR2 and CXCR4 was described in T cells in vitro [18].
MIF Binding (association) of in T cells associated with chemokine
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.80 Pain Relevance 0.44
In this study we confirm these in vitro finding since we demonstrate 1) co-localization of CXCR4 and MIF in the urothelium, both in saline treated rats and after CYP treatment; 2) CXCR4-MIF associations are present in saline-treated bladder and increase after CYP treatment.
MIF Binding (associations) of in bladder
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.44 Pain Relevance 0.36
MIF binds to cell-surface CD74 [15] and the MIF-CD74 complex then activates signal transduction by binding to another cell-surface receptor, CD44 [14].
MIF Binding (binds) of
13) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.00 Pain Relevance 0.41
However, a small amount was found co-immunoprecipitated with CXCR4 in the saline-treated rats and these CXCR4-MIF complexes increased after CYP treatment.
MIF Binding (complexes) of
14) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.13 Pain Relevance 0.07
The exact role of CXCR4 and MIF-CXCR4 associations in the bladder was not addressed in the present study and remains to be investigated.
MIF Binding (associations) of in bladder
15) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.26
The object of the present study was to determine if there was an association between MIF and CXCR4 receptors in the bladder.
MIF Binding (association) of in bladder
16) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.70 Pain Relevance 0.28
Until recently, complex formation between MIF and cell-surface CD74 was the only described mechanism for MIF-receptor interaction [15] .
MIF-receptor Binding (interaction) of
17) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.17 Pain Relevance 0.37
Immunoprecipitation demonstrated an association between CXCR4 and MIF in the bladder.
MIF Binding (association) of in bladder
18) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.46
MIF may exert autocrine effects through binding to intracellular JAB1 [13] and also paracrine effects by binding to cell-surface receptors [14].
MIF Binding (binding) of
19) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.53 Pain Relevance 0.48
MIF may exert autocrine effects through binding to intracellular JAB1 [13] and also paracrine effects by binding to cell-surface receptors [14].
MIF Binding (binding) of
20) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.58 Pain Relevance 0.51

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