INT72959

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 1
hepatocyte 1


Pain Term Frequency Confidence Heat
lidocaine 12 100.00 Very High Very High Very High
halothane 6 62.28 Quite High
antidepressant 2 42.04 Quite Low
sSRI 2 41.04 Quite Low
Paracetamol 2 37.64 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Toxicity 12 84.40 Quite High
Liver Disease 10 58.64 Quite High
Disease Susceptibility 2 54.72 Quite High
Nicotine Addiction 2 35.60 Quite Low
Hepatocellular Cancer 2 34.32 Quite Low
Hepatitis 16 27.44 Quite Low
Alcoholic Liver Diseases 2 22.08 Low Low
Poisoning 2 18.64 Low Low
Disease 26 17.32 Low Low
Autoimmune Hepatitis 136 9.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interactions of lidocaine (LIDO) with two closely related P450s, 2B1 and 2B2, were investigated using chimeric enzymes and single-point mutants derived from the two proteins.
P450s Binding (interactions) of associated with lidocaine
1) Confidence 0.47 Published 1998 Journal Biochemistry Section Abstract Doc Link 9425052 Disease Relevance 0 Pain Relevance 0.49
The resulting antibodies could interact with P450s as antigenic targets in the plasma membrane and cause immune-mediated destruction of the hepatocyte.
P450s Binding (interact) of in hepatocyte
2) Confidence 0.47 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.20 Pain Relevance 0
CYP2D6, CYP1A1, and CYP2E1 have been detected at the cell surface by flow cytometry or biochemical analysis of the plasma membrane [50].The molecular mechanisms responsible for targeting and transport of P450s to these alternative intracellular sites appear to be dependent on the cellular systems and experimental conditions used.
P450s Binding (targeting) of in plasma
3) Confidence 0.36 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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