INT7298

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1984
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 18.23
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 15
myocardium 2
brain 2
coronary artery 2
heart 2
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 15 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
anesthesia 27 99.62 Very High Very High Very High
cva 72 99.32 Very High Very High Very High
Somatostatin 1 99.08 Very High Very High Very High
ischemia 7 98.72 Very High Very High Very High
Angina 16 97.68 Very High Very High Very High
isoflurane 2 97.28 Very High Very High Very High
Dynorphin 4 96.20 Very High Very High Very High
tetrodotoxin 1 89.04 High High
Disease Link Frequency Relevance Heat
Natriuresis 109 100.00 Very High Very High Very High
Cv General 2 Under Development 279 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 98 99.88 Very High Very High Very High
Disorders Of Creatine Metabolism 3 99.40 Very High Very High Very High
Cv General 4 Under Development 69 99.32 Very High Very High Very High
Coronary Heart Disease 9 98.92 Very High Very High Very High
Dyspnea 10 98.76 Very High Very High Very High
Hypotension 28 98.72 Very High Very High Very High
Cv Unclassified Under Development 15 98.72 Very High Very High Very High
Coronary Artery Disease 4 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANP is a 28 amino acid peptide and produced primarily in the cardiac atria [8], stimulated by atrial stretch, for example, volume overloading.
Gene_expression (produced) of ANP
1) Confidence 0.70 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.78 Pain Relevance 0
The overexpression of ANP and BNP suggests an anti-angiogenic effect in ischemic heart disease.
Gene_expression (overexpression) of ANP in heart associated with coronary artery disease
2) Confidence 0.69 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.57 Pain Relevance 0.19
ANP and BNP but not VEGF are regionally overexpressed in ischemic human myocardium.
Gene_expression (overexpressed) of ANP in myocardium
3) Confidence 0.69 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15313204 Disease Relevance 0.59 Pain Relevance 0.22
RESULTS: Nt-proANP levels were significantly influenced by the diagnostic subgroups (ANOVA: p<0.001) and were [geometric mean (range)]: 19727 ng/L (5260-45200) in congestive heart failure (CHF, n=31), 6575 ng/L (1350-36000) in coronary artery disease (CAD, n=19), 5324 ng/L (1710-13150) in pulmonary embolism (PE, n=20), 5035 ng/L (1510-16600) in pulmonary diseases (PD, n=24) and 3001 ng/L (750-11860) in patients without cardiopulmonary diseases (n=43).
Gene_expression (levels) of ANP in coronary artery
4) Confidence 0.65 Published 2008 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19172697 Disease Relevance 0 Pain Relevance 0
RESULTS: Nt-proANP levels were significantly influenced by the diagnostic subgroups (ANOVA: p<0.001) and were [geometric mean (range)]: 19727 ng/L (5260-45200) in congestive heart failure (CHF, n=31), 6575 ng/L (1350-36000) in coronary artery disease (CAD, n=19), 5324 ng/L (1710-13150) in pulmonary embolism (PE, n=20), 5035 ng/L (1510-16600) in pulmonary diseases (PD, n=24) and 3001 ng/L (750-11860) in patients without cardiopulmonary diseases (n=43).
Gene_expression (influenced) of ANP in coronary artery
5) Confidence 0.65 Published 2008 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19172697 Disease Relevance 0 Pain Relevance 0
The cross-reactivity of the oxytocin antibody was 100% with oxytocin and O with Lys-vasopressin, Arg-vasopressin, GH, alpha-ANP, Met-Enkephalin, GRF, somatostatin, TRH, VIP, Pacap 27-NH2.
Gene_expression (vasopressin) of ANP associated with somatostatin and enkephalin
6) Confidence 0.65 Published 2006 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1621060 Disease Relevance 0 Pain Relevance 0.15
Effect of transcatheter closure of ASD on plasma ANP concentrations and 3DE measurements
Gene_expression (concentrations) of plasma ANP in plasma associated with cv general 2 under development
7) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.79 Pain Relevance 0
Plasma ANP concentrations and 3DE measurements
Gene_expression (concentrations) of Plasma ANP in Plasma
8) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.55 Pain Relevance 0
There were significant positive correlation between plasma ANP concentrations and PAP (r = 0.74; p < 0.05) (Fig 4).


Gene_expression (concentrations) of plasma ANP in plasma
9) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.76 Pain Relevance 0
Correlation between Plasma ANP concentrations with PAP
Gene_expression (concentrations) of Plasma ANP in Plasma
10) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.64 Pain Relevance 0
Correlation between Plasma ANP concentrations and 3DE measurements
Gene_expression (concentrations) of Plasma ANP in Plasma
11) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.73 Pain Relevance 0
This finding argues against a specific insulin effect on the ANP-mediated metabolic effect in skeletal muscle.
Gene_expression (effect) of ANP in skeletal muscle
12) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.45 Pain Relevance 0
The plasma levels of ANP and cGMP did not change after hyperventilation on days 1 and 3.
Gene_expression (levels) of ANP in plasma associated with dyspnea
13) Confidence 0.60 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8392283 Disease Relevance 0.98 Pain Relevance 0.35
HS-142-1, a novel polysaccharide, isolated from the culture broth of Aureobasidium pullulans var. melanigenum, has been found to inhibit selectively the binding of [125I]atrial natriuretic peptide (ANP) to the guanylyl cyclase-linked ANP receptor (ANP-B receptor) and production of cyclic GMP by ANP.
Gene_expression (production) of ANP associated with natriuresis
14) Confidence 0.60 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1346647 Disease Relevance 0.42 Pain Relevance 0.04
Both ANP and BNP but not vascular endothelial growth factor (VEGF) and VEGF-receptor 1 and 2 were overexpressed in ischemic regions compared to non-ischemic regions as measured by real-time PCR.
Gene_expression (overexpressed) of ANP
15) Confidence 0.60 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15313204 Disease Relevance 0.63 Pain Relevance 0.22
These results indicate that chronic inanition due to surreptitious vomiting causes impaired renal diluting ability through decreases in GFR and RPF, irrespective of the levels of plasma AVP and ANP.
Gene_expression (levels) of ANP in plasma associated with disorders of creatine metabolism and vomiting
16) Confidence 0.59 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.83 Pain Relevance 0.05
The effect of two analogues of [Met]-enkephalin, [D-Ala2,N-Phe4,Met(0)-ol5]-enkephalin and its guanyl derivative, on plasma concentrations of atrial natriuretic peptide (ANP) and serum aldosterone in six normal subjects was investigated.
Spec (investigated) Gene_expression (effect) of ANP in plasma associated with natriuresis and enkephalin
17) Confidence 0.56 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2965206 Disease Relevance 0.25 Pain Relevance 0.30
During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines.
Gene_expression (levels) of atrial natriuretic factor in plasma associated with natriuresis, dynorphin and catecholamine
18) Confidence 0.54 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.39
During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines.
Gene_expression (levels) of ANF in plasma associated with natriuresis, dynorphin and catecholamine
19) Confidence 0.54 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.39
During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines.
Gene_expression (levels) of atrial natriuretic factor in plasma associated with natriuresis, dynorphin and catecholamine
20) Confidence 0.54 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox