INT72990

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Context Info
Confidence 0.25
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
TGNs 1
postsynaptic membrane 1
Gphn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 96.16 Very High Very High Very High
GABAergic 39 90.20 High High
Calcitonin gene-related peptide 5 88.04 High High
qutenza 2 85.76 High High
tetrodotoxin 11 82.96 Quite High
Spinal cord 3 75.36 Quite High
antagonist 4 74.20 Quite High
medulla 1 71.20 Quite High
Lasting pain 2 64.52 Quite High
central sensitization 1 63.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 86.36 High High
Pain 3 64.52 Quite High
INFLAMMATION 1 59.08 Quite High
Toxicity 1 27.12 Quite Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Phototoxic Dermatitis 1 5.00 Very Low Very Low Very Low
Vibrio Infection 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, while GlyRs could be subdivided between “immobilized” receptors and “swapping” receptors entering gephyrin clusters just for short dwell times, no comparable separation was apparent here for ?
gephyrin Binding (entering) of
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.11
The fact that gephyrin postsynaptic localization was not modified by strychnine suggests that the aggregation of glycine receptor and gephyrin is governed by different mechanisms.
gephyrin Binding (aggregation) of
2) Confidence 0.18 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.11
The glycine receptor (GlyR) and its cytoplasmic domain-associated protein, gephyrin, are clustered at the postsynaptic membrane and constitute a good model for addressing these questions.
gephyrin Binding (clustered) of in postsynaptic membrane
3) Confidence 0.14 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.09
It bound effectively to the C isoform of SV2 abundantly expressed in TGNs and cleaved SNAP-25, indicating that its /A binding domain (H(C)) mediated uptake of the active /E protease.
isoform Binding (bound) of in TGNs
4) Confidence 0.00 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19369567 Disease Relevance 0.34 Pain Relevance 0.64

General Comments

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