INT72991

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)
Gphn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 99.82 Very High Very High Very High
Spinal cord 3 83.20 Quite High
Pyramidal cell 24 82.92 Quite High
Central nervous system 3 65.68 Quite High
nMDA receptor 4 61.84 Quite High
GABAergic 3 49.12 Quite Low
Cannabinoid receptor 1 45.52 Quite Low
Hippocampus 17 35.92 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 16 98.52 Very High Very High Very High
Convulsion 18 84.88 Quite High
Status Epilepticus 57 50.00 Quite Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Gliosis 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also detected a down-regulation of the gephyrin gene and an up-regulation of the GABARAP gene in accordance with the results obtained from the hippocampi of humans with TLE [86].
Regulation (regulation) of gephyrin associated with epilepsy
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.34 Pain Relevance 0.10
Chronic exposure of the cultures to tetrodotoxin did not affect gephyrin or glycine receptor cluster formation.
Neg (not) Regulation (affect) of gephyrin associated with tetrodotoxin
2) Confidence 0.15 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.10
The fact that gephyrin postsynaptic localization was not modified by strychnine suggests that the aggregation of glycine receptor and gephyrin is governed by different mechanisms.
Neg (not) Regulation (modified) of gephyrin
3) Confidence 0.09 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.11
The proportion of gephyrin and glycine receptor-immunoreactive (IR) cells was unaffected by strychnine treatment.
Neg (unaffected) Regulation (unaffected) of gephyrin
4) Confidence 0.04 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.07

General Comments

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