INT72991

Context Info Confidence 0.22 First Reported 1998 Last Reported 2010 Negated 3 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.34 Pain Relevance 0.38

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)

Gphn (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 3 99.82 Spinal cord 3 83.20 Pyramidal cell 24 82.92 Central nervous system 3 65.68 nMDA receptor 4 61.84 GABAergic 3 49.12 Cannabinoid receptor 1 45.52 Hippocampus 17 35.92 Inflammation 11 5.00 chemokine 4 5.00

Disease Link Frequency Relevance Heat Epilepsy 16 98.52 Convulsion 18 84.88 Status Epilepticus 57 50.00 INFLAMMATION 12 5.00 Apoptosis 8 5.00 Injury 4 5.00 Gliosis 4 5.00 Death 2 5.00 Cv Unclassified Under Development 2 5.00 Disorder Of Lipid Metabolism 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also detected a down-regulation of the gephyrin gene and an up-regulation of the GABARAP gene in accordance with the results obtained from the hippocampi of humans with TLE [86].

Regulation (regulation) of gephyrin associated with epilepsy

1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.34 Pain Relevance 0.10

Chronic exposure of the cultures to tetrodotoxin did not affect gephyrin or glycine receptor cluster formation.

Neg (not) Regulation (affect) of gephyrin associated with tetrodotoxin

2) Confidence 0.15 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.10

The fact that gephyrin postsynaptic localization was not modified by strychnine suggests that the aggregation of glycine receptor and gephyrin is governed by different mechanisms.

Neg (not) Regulation (modified) of gephyrin

3) Confidence 0.09 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.11

The proportion of gephyrin and glycine receptor-immunoreactive (IR) cells was unaffected by strychnine treatment.

Neg (unaffected) Regulation (unaffected) of gephyrin

4) Confidence 0.04 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.07

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