INT72992

Context Info Confidence 0.50 First Reported 1998 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.19 Pain Relevance 0.80

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)

Anatomy Link Frequency nucleus 1 Gphn (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 62 99.68 gABA 22 94.36 Spinal cord 1 94.20 Cannabinoid 5 93.48 tetrodotoxin 3 92.28 agonist 7 79.20 Central nervous system 1 76.68 antagonist 2 62.36 hyperexcitability 1 5.00 long-term potentiation 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 122 96.64 Stress 42 50.00 Post-traumatic Stress Disorder 16 5.00 Shock 7 5.00 Cognitive Disorder 6 5.00 Injury 4 5.00 Phobia 3 5.00 Overactive Bladder 1 5.00 Disease 1 5.00 Affective Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The abundance of GlyR subunits and gephyrin fell sharply in the axotomized facial nucleus.

Transcription (abundance) of gephyrin in nucleus

1) Confidence 0.50 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733085 Disease Relevance 0 Pain Relevance 0.16

Chhatwal et al. [100] showed that gephyrin mRNA and protein levels in the BLA significantly

Transcription (levels) of gephyrin associated with amygdala

2) Confidence 0.26 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 0.19 Pain Relevance 0.55

Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the glycine receptor alpha1, alpha2, beta subunits and gephyrin mRNAs were expressed at comparable levels in strychnine-treated and untreated cultures.

Transcription (expressed) of gephyrin

3) Confidence 0.20 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.09

General Comments

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