INT73010

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.38
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tmem132a) endoplasmic reticulum (Tmem132a)
Anatomy Link Frequency
paw 1
tail 1
striatum 1
Tmem132a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 78 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
pregabalin 4 99.92 Very High Very High Very High
Antinociceptive 5 99.84 Very High Very High Very High
gABA 19 99.76 Very High Very High Very High
anticonvulsant 12 99.64 Very High Very High Very High
Raphe magnus 2 98.72 Very High Very High Very High
GABA receptor 2 98.04 Very High Very High Very High
withdrawal 6 98.00 Very High Very High Very High
Acute pain 1 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 13 100.00 Very High Very High Very High
Anxiety Disorder 3 99.44 Very High Very High Very High
Epilepsy 99 98.36 Very High Very High Very High
Nociception 3 97.48 Very High Very High Very High
Pain 8 97.24 Very High Very High Very High
Shock 1 96.88 Very High Very High Very High
Convulsion 125 96.32 Very High Very High Very High
Hyperalgesia 1 95.88 Very High Very High Very High
Post Operative Pain 2 95.84 Very High Very High Very High
Stress 2 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gabapentin (GBP) is a gamma-aminobutyric acid analog originally synthesized for its anticonvulsant actions.
Gene_expression (synthesized) of GBP associated with anticonvulsant and gabapentin
1) Confidence 0.77 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9428862 Disease Relevance 0.42 Pain Relevance 1.01
Gabapentin (GBP) is well tolerated and shows very favorable side effects profile: The exact molecular mechanism of action of GBP to block postoperative pain and stress is not known.
Gene_expression (tolerated) of GBP associated with stress, perioperative pain and gabapentin
2) Confidence 0.67 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17873368 Disease Relevance 0.45 Pain Relevance 1.03
Present results indicate that GBP may differentially modulate c-Fos expression in surgical paw incision.
Gene_expression (expression) of GBP in paw associated with gabapentin
3) Confidence 0.60 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17873368 Disease Relevance 0.05 Pain Relevance 0.91
GBP administered in the dose of 25 mg/kg intraperitoneal (i.p.) significantly reduced the immobility time on days 1 and 7 of the test in animals exposed to tobacco smoke, and on days 7 and 14 of the test in rats not exposed to tobacco smoke.
Neg (not) Gene_expression (exposed) of GBP associated with nicotine addiction and gabapentin
4) Confidence 0.59 Published 2008 Journal Hum Exp Toxicol Section Abstract Doc Link 19273543 Disease Relevance 1.31 Pain Relevance 1.00
BACKGROUND: Recently, gabapentin-lactam (GBP-L) was shown to be neuroprotective in vivo.
Gene_expression (neuroprotective) of GBP-L associated with gabapentin
5) Confidence 0.57 Published 2004 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Abstract Doc Link 14770318 Disease Relevance 0.07 Pain Relevance 0.17
Systemic (1S,3R)3-MeGBP, but not GBP or (1R,3R)3-MeGBP, also produced an antinociceptive effect in the warm water tail withdrawal test of acute pain.
Gene_expression (produced) of GBP in tail associated with acute pain, withdrawal, antinociceptive and gabapentin
6) Confidence 0.52 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15734900 Disease Relevance 0.71 Pain Relevance 1.76
Our present study demonstrated that, administration of GBP (150 mg/kg, i.p.) in combination with morphine (10 mg/kg, i.p.) significantly (p < 0.01) attenuated the acute morphine (10 mg/kg, i.p.) induced c-Fos expression in the rat striatum.
Gene_expression (expression) of GBP in striatum associated with gabapentin and morphine
7) Confidence 0.26 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17873287 Disease Relevance 0 Pain Relevance 1.86
GBP synthesized as a GABA-ergic drug does not interact with the GABA receptors but is a ligand of the ?
Gene_expression (synthesized) of GBP associated with gaba, gaba receptor and gabapentin
8) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.36 Pain Relevance 1.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox