INT73022

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 21
Total Number 24
Disease Relevance 10.61
Pain Relevance 6.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) nucleus (EGR1) intracellular (EGR1)
DNA binding (EGR1) cytoplasm (EGR1)
Anatomy Link Frequency
finger 6
endothelial cells 4
anterior 2
fibroblasts 2
A549 2
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 54 99.98 Very High Very High Very High
COX-2 inhibitor 7 99.50 Very High Very High Very High
cytokine 23 99.34 Very High Very High Very High
Dorsal horn 1 99.20 Very High Very High Very High
Spinal cord 1 98.44 Very High Very High Very High
allodynia 4 98.36 Very High Very High Very High
cINOD 44 98.32 Very High Very High Very High
Sciatic nerve 1 96.44 Very High Very High Very High
Ventral tegmentum 46 94.96 High High
Dopamine 10 94.60 High High
Disease Link Frequency Relevance Heat
Glioma 24 100.00 Very High Very High Very High
Apoptosis 69 99.36 Very High Very High Very High
Neuropathic Pain 4 98.36 Very High Very High Very High
INFLAMMATION 115 98.12 Very High Very High Very High
Shock 1 95.92 Very High Very High Very High
Rheumatoid Arthritis 7 95.00 High High
Cancer 31 94.24 High High
Injury 7 93.48 High High
Lung Cancer 6 92.72 High High
Stress 31 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In terms of signaling pathway, ERK1/2 MAP kinases and its substrate Elk-1 transcription factor were involved in the sulindac sulfide-induced EGR-1 gene expression.
Positive_regulation (induced) of Gene_expression (expression) of EGR-1 gene
1) Confidence 0.69 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.81 Pain Relevance 0.31
VEGF treatment caused a significant elevation of Egr-1 mRNA (261+/-21%, P<0.001) and protein expression (174+/-15%, P<0.01) vs. vehicle.
Positive_regulation (caused) of Gene_expression (expression) of Egr-1
2) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.27 Pain Relevance 0.39
Although further studies are needed to demonstrate that increased expression of Egr-1 by platycodon D leads directly to NAG-1 induction and subsequent apoptosis, our observations clearly indicate that ROS induced through Egr-1 activation are involved in the early molecular events involved in the platycodon D-induced apoptotic pathway.
Positive_regulation (increased) of Gene_expression (expression) of Egr-1 associated with apoptosis
3) Confidence 0.66 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.84 Pain Relevance 0.13
Here, we show by Western blot experiments that substance P induced a transient synthesis of the zinc finger transcriptional regulator Egr-1 in human glioma cells.
Positive_regulation (induced) of Gene_expression (synthesis) of Egr-1 in finger associated with glioma and substance p
4) Confidence 0.65 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.54 Pain Relevance 0.46
These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis.
Positive_regulation (activation) of Gene_expression (biosynthesis) of Egr-1 associated with substance p
5) Confidence 0.65 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.43 Pain Relevance 0.49
Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase.
Positive_regulation (induced) of Gene_expression (biosynthesis) of Egr-1 in finger associated with glioma and substance p
6) Confidence 0.65 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12384223 Disease Relevance 0.53 Pain Relevance 0.46
For example, overexpression of Egr-1 protein induced ATF3 mRNA 3.5-fold and transcriptional activity of an ATF3 promoter construct more than 20-fold.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Egr-1
7) Confidence 0.62 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.22 Pain Relevance 0.07
Inhibition of isochaihulactone-induced NAG-1 expression by EGR-1 small interfering RNA blocked isochaihulactone-induced apoptosis in A549 cells, suggesting that induction of EGR-1 expression decreases survival of A549 cells.
Positive_regulation (induction) of Gene_expression (expression) of EGR-1 in A549 associated with apoptosis
8) Confidence 0.59 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.81 Pain Relevance 0.15
This study aimed to determine whether indomethacin (IND) and/or the selective COX-2 inhibitor, NS-398, interfere with egr-1 gene expression in human microvascular endothelial cells (HMVEC) in response to vascular endothelial growth factor (VEGF) stimulation.
Spec (whether) Positive_regulation (response) of Gene_expression (expression) of egr-1 in endothelial cells associated with cox-2 inhibitor
9) Confidence 0.49 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.33 Pain Relevance 0.39
Initial studies found that the level and pattern of neural activity [16] and expression of the immediate early gene egr-1 (also known as zif268, ZENK, and NGF [15]) are strongly dependent on the social context in which males sing in the anterior forebrain nuclei LMAN and Area X, as well as in the motor nucleus RA.
Positive_regulation (dependent) of Gene_expression (expression) of zif268 in anterior associated with rheumatoid arthritis
10) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533700 Disease Relevance 0.10 Pain Relevance 0.30
Expression of three of the immediate early genes examined, c-fos, NGFI-A and jun B, was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve.
Spec (partial) Positive_regulation (increased) of Gene_expression (Expression) of NGFI-A in dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
11) Confidence 0.49 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429660 Disease Relevance 0.41 Pain Relevance 0.56
Substance P-induced stimulation of Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor.
Positive_regulation (stimulation) of Gene_expression (biosynthesis) of Egr-1 associated with substance p
12) Confidence 0.47 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.52 Pain Relevance 0.45
Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase.
Positive_regulation (requires) of Gene_expression (biosynthesis) of Egr-1 in finger associated with glioma and substance p
13) Confidence 0.47 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12384223 Disease Relevance 0.54 Pain Relevance 0.46
VEGF treatment caused a significant elevation of Egr-1 mRNA (261+/-21%, P<0.001) and protein expression (174+/-15%, P<0.01) vs. vehicle.
Positive_regulation (elevation) of Gene_expression (expression) of Egr-1
14) Confidence 0.46 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.27 Pain Relevance 0.38
The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds.
Positive_regulation (induction) of Gene_expression (expression) of Egr-1 mRNA
15) Confidence 0.45 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0 Pain Relevance 0
Interestingly, endothelial cells contrasted with HT29 cells in that induced EGR1 expression in these cells was found to be suppressed by curcumin [72].
Positive_regulation (induced) of Gene_expression (expression) of EGR1 in endothelial cells
16) Confidence 0.45 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.44 Pain Relevance 0
Moreover, we show that the signaling cascade initiated by substance P or EGF are indistinguishable, including the activation of the EGF receptor, the activation of ERK, and the final stimulation of Egr-1 biosynthesis.
Positive_regulation (stimulation) of Gene_expression (biosynthesis) of Egr-1 associated with substance p
17) Confidence 0.43 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.39 Pain Relevance 0.47
Isochaihulactone increased EGR-1 and then NAG-1 mRNA and protein expression.
Positive_regulation (increased) of Gene_expression (expression) of EGR-1
18) Confidence 0.43 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.64 Pain Relevance 0.17
Isochaihulactone-induced increases in EGR-1 and NAG-1 expression were reduced by the mitogen-activated protein kinase kinase 1/2 inhibitor 2'-amino-3'-methoxyflavone (PD98059), and this effect was not blocked by the phosphatidylinositol 3-kinase/protein kinase B pathway inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002).
Positive_regulation (increases) of Gene_expression (expression) of EGR-1
19) Confidence 0.43 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.67 Pain Relevance 0.17
Numerous cytokines and growth factors are known to upregulate mPGES-1 production via Egr-1 activation [38].
Positive_regulation (activation) of Gene_expression (production) of Egr-1 associated with cytokine
20) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.24 Pain Relevance 0.17

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