INT73023

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.23
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) nucleus (EGR1) intracellular (EGR1)
DNA binding (EGR1) cytoplasm (EGR1)
Anatomy Link Frequency
epithelial cells 2
proximal 1
dorsal horn 1
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 100.00 Very High Very High Very High
Dorsal horn 1 100.00 Very High Very High Very High
Sciatic nerve 1 99.68 Very High Very High Very High
cINOD 17 98.04 Very High Very High Very High
Inflammation 104 96.36 Very High Very High Very High
allodynia 4 95.72 Very High Very High Very High
cytokine 12 94.88 High High
COX2 4 94.72 High High
Pain 7 85.48 High High
Lasting pain 5 83.56 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 146 99.68 Very High Very High Very High
Injury 4 99.22 Very High Very High Very High
Death 33 97.32 Very High Very High Very High
INFLAMMATION 129 96.36 Very High Very High Very High
Colon Cancer 11 95.92 Very High Very High Very High
Neuropathic Pain 4 95.72 Very High Very High Very High
Cancer 99 95.12 Very High Very High Very High
Ulcers 2 93.88 High High
Esophageal Disease 36 87.04 High High
Pain 10 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, NSAID sulindac sulfide was investigated for the cytotoxic injury in the intestinal epithelial cells in association with an immediate inducible factor, early growth response gene 1 (EGR-1).
EGR-1 Binding (association) of in epithelial cells associated with injury and cinod
1) Confidence 0.48 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.68 Pain Relevance 0.40
In the present study, NSAID sulindac sulfide was investigated for the cytotoxic injury in the intestinal epithelial cells in association with an immediate inducible factor, early growth response gene 1 (EGR-1).
early growth response gene 1 Binding (association) of in epithelial cells associated with injury and cinod
2) Confidence 0.48 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.68 Pain Relevance 0.40
Expression of three of the immediate early genes examined, c-fos, NGFI-A and jun B, was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve.
NGFI-A Spec (partial) Binding (ligation) of in dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
3) Confidence 0.36 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429660 Disease Relevance 0.46 Pain Relevance 0.56
We hypothesized that the induction of Egr-1 activity by HNE could be the mechanism by which HNE exerts its stimulatory effect on mPGES-1 transcription.
Egr-1 Binding (activity) of
4) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.23 Pain Relevance 0.16
Emerging evidence has disclosed that the transcriptional induction of mPGES-1 is primarily controlled by Egr-1 through two Egr-1 binding motifs identified in the proximal promoter region of mPGES-1 [36,37].
Egr-1 Binding (binding) of in proximal
5) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.20 Pain Relevance 0.17
 ; EGR-1: forward primer, 5?
EGR-1 Binding (primer) of
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0
However, this same variant, while altering the Sp1/Sp3 site, also introduces a binding site for another transcription factor, Egr-1, although the consequences are unknown [22].
Egr-1 Binding (binding) of
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.68 Pain Relevance 0.17
EGR-1 has been linked to
EGR-1 Binding (linked) of
8) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.29 Pain Relevance 0

General Comments

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