INT73045

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Context Info
Confidence 0.12
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.08
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Nsa2) cellular_component (Nsa2) biological_process (Nsa2)
Anatomy Link Frequency
nerve 2
Nsa2 (Mus musculus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 7 98.76 Very High Very High Very High
agonist 1 97.84 Very High Very High Very High
Potency 3 93.36 High High
antinociception 2 90.48 High High
Analgesic 2 89.84 High High
Pain 24 86.00 High High
withdrawal 29 84.48 Quite High
Antinociceptive 2 75.00 Quite High
cytokine 40 73.00 Quite High
Inflammation 42 72.60 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 61 98.76 Very High Very High Very High
Pain 33 98.08 Very High Very High Very High
Nervous System Injury 146 97.92 Very High Very High Very High
Sprains And Strains 1 96.62 Very High Very High Very High
Targeted Disruption 66 87.68 High High
Nociception 7 76.80 Quite High
INFLAMMATION 44 72.60 Quite High
Inflammatory Pain 25 63.60 Quite High
Neuropathic Pain 49 62.44 Quite High
Injury 11 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male mice of the CD-1 strain were injected with different doses of the muscarinic agonist oxotremorine (0.005, 0.01, 0.02, 0.03 mg/kg i.p.) 5 min after the administration of saline solution or the inhibitors of NO synthase NG-nitro-L-arginine methyl ester (L-NAME: 10 and 20 mg/kg, i.p.) or NG-nitro-L-arginine (N-ARG: 10 and 20 mg/kg i.p.).
Negative_regulation (inhibitors) of L-NAME associated with agonist and sprains and strains
1) Confidence 0.12 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9431549 Disease Relevance 0.26 Pain Relevance 0.49
A nonspecific NOS inhibitor, L-NG-nitro-arginine methyl ester (L-NAME) and its inactive enantiomer, D-NAME, were administered intraperitoneally on day 7 post-nerve injury.
Negative_regulation (inhibitor) of L-NAME in nerve associated with nervous system injury
2) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.63 Pain Relevance 0.31
A nonspecific NOS inhibitor, L-NG-nitro-arginine methyl ester (L-NAME) and its inactive enantiomer, D-NAME, were administered intraperitoneally on day 7 post-nerve injury.
Negative_regulation (inhibitor) of D-NAME in nerve associated with nervous system injury
3) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.64 Pain Relevance 0.31
Interestingly, pretreatment with L-NAME, a non-selective NOS inhibitor, augmented the increase of IL-10 in CFA mice.
Negative_regulation (inhibitor) of L-NAME
4) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.54 Pain Relevance 0.71

General Comments

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