INT73045

Context Info Confidence 0.12 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 4.08 Pain Relevance 1.82

molecular_function (Nsa2) cellular_component (Nsa2) biological_process (Nsa2)

Anatomy Link Frequency nerve 2 Nsa2 (Mus musculus)

Pain Link Frequency Relevance Heat Stimulus evoked pain 7 98.76 agonist 1 97.84 Potency 3 93.36 antinociception 2 90.48 Analgesic 2 89.84 Pain 24 86.00 withdrawal 29 84.48 Antinociceptive 2 75.00 cytokine 40 73.00 Inflammation 42 72.60

Disease Link Frequency Relevance Heat Hypersensitivity 61 98.76 Pain 33 98.08 Nervous System Injury 146 97.92 Sprains And Strains 1 96.62 Targeted Disruption 66 87.68 Nociception 7 76.80 INFLAMMATION 44 72.60 Inflammatory Pain 25 63.60 Neuropathic Pain 49 62.44 Injury 11 56.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Male mice of the CD-1 strain were injected with different doses of the muscarinic agonist oxotremorine (0.005, 0.01, 0.02, 0.03 mg/kg i.p.) 5 min after the administration of saline solution or the inhibitors of NO synthase NG-nitro-L-arginine methyl ester (L-NAME: 10 and 20 mg/kg, i.p.) or NG-nitro-L-arginine (N-ARG: 10 and 20 mg/kg i.p.).

Negative_regulation (inhibitors) of L-NAME associated with agonist and sprains and strains

1) Confidence 0.12 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9431549 Disease Relevance 0.26 Pain Relevance 0.49

A nonspecific NOS inhibitor, L-NG-nitro-arginine methyl ester (L-NAME) and its inactive enantiomer, D-NAME, were administered intraperitoneally on day 7 post-nerve injury.

Negative_regulation (inhibitor) of L-NAME in nerve associated with nervous system injury

2) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.63 Pain Relevance 0.31

A nonspecific NOS inhibitor, L-NG-nitro-arginine methyl ester (L-NAME) and its inactive enantiomer, D-NAME, were administered intraperitoneally on day 7 post-nerve injury.

Negative_regulation (inhibitor) of D-NAME in nerve associated with nervous system injury

3) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.64 Pain Relevance 0.31

Interestingly, pretreatment with L-NAME, a non-selective NOS inhibitor, augmented the increase of IL-10 in CFA mice.

Negative_regulation (inhibitor) of L-NAME

4) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.54 Pain Relevance 0.71

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