INT73047

Context Info Confidence 0.68 First Reported 1997 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 133 Total Number 134 Disease Relevance 73.22 Pain Relevance 26.42

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)

Anatomy Link Frequency neutrophils 7 coronary artery 5 bar 4 plaque 4 chondrocytes 3 MMP9 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1930 100.00 Angina 215 99.90 cytokine 519 99.84 Inflammatory response 79 99.38 Inflammation 1231 99.20 rheumatoid arthritis 888 98.24 Dismenorea 21 97.64 alcohol 133 97.44 fibrosis 243 96.96 imagery 80 96.92

Disease Link Frequency Relevance Heat Asthma 51 99.98 Atherosclerosis 315 99.96 Major Depressive Disorder 100 99.96 Angina 138 99.90 Coronary Artery Disease 329 99.88 Nicotine Addiction 724 99.84 Prostate Cancer 701 99.84 Disease 653 99.84 Lung Cancer 153 99.84 Diabetes Mellitus 113 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the AA-induced activity of MMP-9 did not diminish in the presence of n-3 fatty acids, although the cellular fatty acid content revealed an ample availability of n-3 fatty acids after incubation.

Positive_regulation (induced) of MMP-9

1) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.04

As shown in Fig. 2B, MMP-9 activity was augmented already after 1 h incubation with AA and increased for at least 6 h.

Positive_regulation (augmented) of MMP-9

2) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].

Positive_regulation (Activated) of MMP9 associated with metalloproteinase

3) Confidence 0.62 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.88 Pain Relevance 0.23

1 mRNA were upregulated at POD 5, then NAMPT, EGR1 and MMP9 mRNA.

Positive_regulation (upregulated) of MMP9 mRNA

4) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.82 Pain Relevance 0.10

Experiments where MonoMac 6 cells were pre exposed to AA for increasing periods of time (Fig. 2B) showed that the system delivering MMP-9 to the medium was activated already after 1 h incubation and increased for at least 6 h.

Positive_regulation (activated) of MMP-9

5) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0.03

As shown in Fig 5, Ly 294002 blocked the induction of MMP-9 by AA and PMA in a dose-dependent manner.

Positive_regulation (induction) of MMP-9

6) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

The transcriptional regulatory mechanism was confirmed by the increase of MMP-9 mRNA by AA treatment.

Positive_regulation (increase) of MMP-9 mRNA

7) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

It is not known whether AA causes degranulation in MonoMac 6 cells, but the continued accumulation of MMP-9 in the incubation medium speaks for additional mechanisms.

Positive_regulation (accumulation) of MMP-9

8) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Published results thus suggest that localized increase in MMP-9 associated with an inflammatory process in the vascular wall has the potential to weaken the tissue structure thus increasing the risk for plaque rupture.

Positive_regulation (increase) of MMP-9 in plaque associated with inflammation and rupture

9) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 1.16 Pain Relevance 0.45

These results suggest that the surface expression of CD44 is required for the activation of MMP-9.

Positive_regulation (activation) of MMP-9

10) Confidence 0.52 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0

This implies that CRP and MMP-9, at least to some extent, could be markers of different physiological pathways.

Positive_regulation (least) of MMP-9

11) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.23 Pain Relevance 0.05

As shown in Fig. 2B, MMP-9 activity was augmented already after 1 h incubation with AA and increased for at least 6 h.

Positive_regulation (increased) of MMP-9

12) Confidence 0.49 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Elevated levels of circulating matrix metalloproteinase-9 (MMP-9) have been demonstrated in patients with established coronary artery disease (CAD).

Positive_regulation (levels) of MMP-9 in coronary artery associated with coronary artery disease and metalloproteinase

13) Confidence 0.46 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2258002 Disease Relevance 0.28 Pain Relevance 0.09

So far, most studies exploring elevated levels of MMP-9 and its association to coronary artery disease (CAD) have been based on a experimental or clinical design, the latter showing elevated levels of plasma MMP-9 in patients with CAD [13]–[18].

Positive_regulation (elevated) of MMP-9 in coronary artery associated with coronary artery disease

14) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 1.44 Pain Relevance 0.28

Elevated levels of circulating matrix metalloproteinase-9 (MMP-9) have been demonstrated in patients with established coronary artery disease (CAD).

Positive_regulation (levels) of matrix metalloproteinase-9 in coronary artery associated with coronary artery disease and metalloproteinase

15) Confidence 0.46 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2258002 Disease Relevance 0.28 Pain Relevance 0.09

RESULTS: A correlation was found between the increasing levels of matrix metalloproteinases 2 and 9 and the grade of degenerative disc disease.

Positive_regulation (increasing) of matrix metalloproteinases 2 and 9

16) Confidence 0.46 Published 1997 Journal Spine Section Body Doc Link 9431623 Disease Relevance 0.12 Pain Relevance 0

MMP-9 activity is controlled at different levels: transcriptional activation of the gene by cytokines and other factors, activation of the pro-enzyme by various enzymes like serine proteases and regulation by specific tissue inhibitors of the matrix metalloproteinases (TIMPs).

Positive_regulation (activation) of MMP-9 associated with metalloproteinase and cytokine

17) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.92 Pain Relevance 0.50

Since there was an increase in MMP-9 activity in the conditioned media of PC3/OPN cells (Figure 1B), we determine the surface levels of MMP-9 in PC3 cell lines (Figure 2C).

Positive_regulation (increase) of MMP-9

18) Confidence 0.45 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0

MMP-9 activity was greatly enhanced in OPN over expressing clones which are represented as C1–C4 (B, lanes 3–6) as compared with PC3 cells (lane 2).

Positive_regulation (enhanced) of MMP-9

19) Confidence 0.45 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.40 Pain Relevance 0.04

Metalloproteinases (MMP-2 and MMP-9) are upregulated in the optic nerve head of glaucoma patients.

Positive_regulation (upregulated) of MMP-9 in optic nerve head associated with metalloproteinase and glaucoma

20) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 1.30 Pain Relevance 0.08

General Comments

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