INT73048

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2011
Negated 6
Speculated 10
Reported most in Body
Documents 268
Total Number 280
Disease Relevance 159.75
Pain Relevance 57.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
neutrophils 15
macrophages 10
plasma 8
basement membrane 7
plaques 6
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4995 100.00 Very High Very High Very High
cytokine 1264 100.00 Very High Very High Very High
intrathecal 154 99.98 Very High Very High Very High
Osteoarthritis 279 99.68 Very High Very High Very High
Angina 197 99.68 Very High Very High Very High
cva 73 99.66 Very High Very High Very High
Inflammatory stimuli 49 99.62 Very High Very High Very High
Inflammation 2428 99.60 Very High Very High Very High
cINOD 161 99.58 Very High Very High Very High
headache 14 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 410 100.00 Very High Very High Very High
Pancreatic Cancer 385 100.00 Very High Very High Very High
Myocardial Infarction 186 100.00 Very High Very High Very High
Ventricular Remodeling 1 100.00 Very High Very High Very High
Knee Osteoarthritis 2 99.88 Very High Very High Very High
Cancer 4891 99.84 Very High Very High Very High
Prostate Cancer 620 99.84 Very High Very High Very High
Lung Cancer 479 99.84 Very High Very High Very High
Bladder Cancer 231 99.84 Very High Very High Very High
Schizophrenia 150 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating levels of MMP-9 was set as the main outcome measure.
Gene_expression (levels) of MMP-9
1) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.57 Pain Relevance 0.10
In Fig 4 we show that MMP-9 mRNA expression was increased 6- to 8-fold when stimulated with 10 ?
Gene_expression (expression) of MMP-9 mRNA
2) Confidence 0.76 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
Indeed, when we blocked the capability of PI3K to generate PIP3 in MonoMac 6 cells by Ly 294002 (a specific inhibitor of PI3K), MMP-9 production was inhibited in both AA and PMA stimulated cells.
Gene_expression (production) of MMP-9
3) Confidence 0.76 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.07 Pain Relevance 0
These results indicate a role for PI3K activation in the signalling of both AA and PMA to produce MMP-9.
Gene_expression (produce) of MMP-9
4) Confidence 0.76 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
It has been shown that production of MMP-9 is induced by prostaglandin E2 (PGE2), the predominant eicosanoid of macrophages [21].
Gene_expression (production) of MMP-9 in PGE2
5) Confidence 0.76 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.12
This protease was shown to degrade and inactivate 15-PGDH suggesting that elevation of 15-PGDH levels could be due to inhibition of MMP-9 expression by these inhibitors.
Gene_expression (expression) of MMP-9
6) Confidence 0.74 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.47 Pain Relevance 0.40
As seen in Figure 3, compared with cancer-free controls, increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were detected by Western blot.
Gene_expression (expression) of MMP-9 associated with cancer
7) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.73 Pain Relevance 0
We further confirmed the expression levels of three up-regulated proteins (MMP-9, DJ-1 and A1BG) in pancreatic juice, tissue and serum samples using Western blot, IHC or ELISA.
Gene_expression (expression) of MMP-9
8) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.27 Pain Relevance 0.16
The expressions of MMP-9, DJ-1 and A1BG were confirmed by immunohistochemistry in 51 pancreatic cancer and 8 normal pancreas samples that were not included in the proteomic experiment (Table 4; Figure 4).
Gene_expression (expressions) of MMP-9 in pancreas associated with pancreatic cancer
9) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.83 Pain Relevance 0
The relationships with DJ-1, MMP-9 and A1BG expression and clinicopathological parameters were analyzed using Chi-square or Fisher's exact tests.
Gene_expression (expression) of MMP-9
10) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.33 Pain Relevance 0.06
Over-expression of MMP-9 and DJ-1 in pancreatic cancer tissues have been shown in previous studies [10,11].
Gene_expression (Over) of MMP-9 associated with pancreatic cancer
11) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.30 Pain Relevance 0
Western blot analysis demonstrated elevated protein levels of MMP-9, DJ-1 and A1BG in cancerous pancreatic juice compared with cancer-free pancreatic juice, which is consistent with our proteomic findings.
Gene_expression (levels) of MMP-9 associated with cancer
12) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.50 Pain Relevance 0
Our immunohistological study extended the above investigation to larger sample size and revealed that MMP-9 and DJ-1 were expressed in 82.4% and 72.5% of PDAC tissues, significantly higher than that in normal pancreas.
Gene_expression (expressed) of MMP-9 in pancreas associated with adenocarcinoma
13) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.24 Pain Relevance 0
The expression of MMP9, MMP2 and type IV collagen, and macrophages infiltration in each slide were scored as the sum of intensity and positive rate scores.
Gene_expression (expression) of MMP9 in macrophages
14) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.33 Pain Relevance 0
In terms of DFS, the study did not reveal any correlation between DFS with expression levels of MMP9, MMP2, type IV collagen, or MVD.
Gene_expression (expression) of MMP9
15) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.36 Pain Relevance 0
Although the difference of MMP2 expression is significant in terms of the recurrence and metastatic status, the MMP9 expression was not associated with tumor stage, lymph node status, metastasis status, recurrence or not.
Gene_expression (expression) of MMP9 in lymph node associated with cancer, metastasis and recurrence
16) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.72 Pain Relevance 0.03
In support to this theory, this study revealed high expression of MMP9 in advanced GC tumor tissue, especially nearby the BM.
Gene_expression (expression) of MMP9 associated with cancer and stomach cancer
17) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.67 Pain Relevance 0.06
Further more, GC patients with negative MMP9 expression displayed improved overall survival compared to patients with positive MMP9 expression (Median OS was 44.0 and 13.5 months, respectively.
Gene_expression (expression) of MMP9 associated with stomach cancer
18) Confidence 0.70 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.33 Pain Relevance 0.07
Relations between plasma MMP-9 levels and total load of risk factors
Gene_expression (levels) of MMP-9 in plasma
19) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.19 Pain Relevance 0
Relations between plasma MMP-9 levels and total load of risk factors
Gene_expression (plasma) of MMP-9 in plasma
20) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.20 Pain Relevance 0

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