INT73071

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Context Info
Confidence 0.01
First Reported 1998
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe) kinase activity (Insrr)
Cpe (Mus musculus)
Insrr (Mus musculus)
Insrr - D95N (2)
Pain Link Frequency Relevance Heat
Dopamine 12 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
gABA 3 99.96 Very High Very High Very High
agonist 12 99.52 Very High Very High Very High
Opioid 4 94.48 High High
antagonist 6 89.36 High High
Buprenorphine 10 82.16 Quite High
opioid receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D1(-/-) mice had normal GABA(A) receptor levels, reduced dynorphin and substance P, and increased enkephalin mRNA and dopamine D2-like binding.
enkephalin Binding (binding) of ) receptor associated with dopamine, gaba, dynorphin, enkephalin and substance p
1) Confidence 0.01 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.33 Pain Relevance 1.43
Selective agonists such as [D-Ser2,D-Leu5]enkephalin-Thr6 (DSLET) and [D-Ala2,D-Leu5]enkephalin (DADLE) had greatly reduced affinity for the D95N mutant receptor but still inhibited cAMP accumulation, which indicated that the mutant receptor was still functionally coupled to adenylyl cyclase.
enkephalin Binding (affinity) of receptor (D95N) associated with agonist and enkephalin
2) Confidence 0.00 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435189 Disease Relevance 0 Pain Relevance 0.97
Selective agonists such as [D-Ser2,D-Leu5]enkephalin-Thr6 (DSLET) and [D-Ala2,D-Leu5]enkephalin (DADLE) had greatly reduced affinity for the D95N mutant receptor but still inhibited cAMP accumulation, which indicated that the mutant receptor was still functionally coupled to adenylyl cyclase.
enkephalin Binding (affinity) of receptor (D95N) associated with agonist and enkephalin
3) Confidence 0.00 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435189 Disease Relevance 0 Pain Relevance 0.97

General Comments

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