INT73076

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF1, GH1) extracellular region (IGF1, GH1) signal transduction (IGF1)
Anatomy Link Frequency
Thyroid 1
IGF1 (Homo sapiens)
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 96.20 Very High Very High Very High
Clonidine 1 65.36 Quite High
Pain 2 25.00 Low Low
Somatostatin 2 8.44 Low Low
Bioavailability 5 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nutritional Deficiencies 5 99.04 Very High Very High Very High
INFLAMMATION 2 96.20 Very High Very High Very High
Thyroid Disease 30 93.48 High High
Disorder Of Lipid Metabolism 2 83.92 Quite High
Hypoglycemia 15 82.28 Quite High
Laron Syndrome 15 63.56 Quite High
Pressure And Volume Under Development 2 25.00 Low Low
Pain 2 25.00 Low Low
Hypopituitarism 1 14.84 Low Low
Growth Problems 4 9.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum insulin-like growth factor-I (IGF-I) increased from a standard deviation score of -2.64 +/- 0.27 (range -8.8 +3.82; n = 78) to +1.08 +/- 2.87 (range -7.21 to +6.42) at 6 months in the GH/GH group; 38% of the whole group were above the age-specific reference range following treatment [17.6% and 68.9% with subnormal (< 2 SD) or normal (+/- 2 SD) pretreatment levels, respectively].
IGF-I Positive_regulation (increased) of GH
1) Confidence 0.45 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9435425 Disease Relevance 0.17 Pain Relevance 0
Thyroid and nutritional deficiencies should be corrected before initiating rhIGF-1. rhIGF-1 is not a substitute for GH.”17,19
rhIGF-1 Neg (not) Positive_regulation (substitute) of GH in Thyroid associated with nutritional deficiencies
2) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.66 Pain Relevance 0.08
Serum insulin-like growth factor-I (IGF-I) increased from a standard deviation score of -2.64 +/- 0.27 (range -8.8 +3.82; n = 78) to +1.08 +/- 2.87 (range -7.21 to +6.42) at 6 months in the GH/GH group; 38% of the whole group were above the age-specific reference range following treatment [17.6% and 68.9% with subnormal (< 2 SD) or normal (+/- 2 SD) pretreatment levels, respectively].
IGF-I Positive_regulation (increased) of GH
3) Confidence 0.20 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9435425 Disease Relevance 0.17 Pain Relevance 0
It should be mentioned that - though IGF-I is the main peripheral mediator of GH action - children with normal IGF-I secretion may be diagnosed as GH-deficient and qualified to rhGH therapy in the light of current national recommendations, enclosed in the programme of therapy of GHD in children with rhGH [21].
IGF-I Positive_regulation (mediator) of GH
4) Confidence 0.13 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0 Pain Relevance 0.07

General Comments

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