INT73095

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.48
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PAF1)
Anatomy Link Frequency
smooth muscle 1
BxPC-3 1
HPAF-II 1
PAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 6 97.12 Very High Very High Very High
Morphine 1 95.32 Very High Very High Very High
beta blocker 7 92.48 High High
qutenza 3 90.64 High High
agonist 1 90.52 High High
tolerance 5 80.24 Quite High
Neuropeptide 2 79.96 Quite High
fibrosis 2 24.24 Low Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 97 99.84 Very High Very High Very High
Heart Rate Under Development 15 99.72 Very High Very High Very High
Coronary Artery Disease 2 98.28 Very High Very High Very High
Cv General 3 Under Development 4 97.12 Very High Very High Very High
Adenocarcinoma 102 89.04 High High
Clostridium Infection 2 83.28 Quite High
Arrhythmia Under Development 9 66.80 Quite High
Metastasis 46 55.52 Quite High
Diabetes Mellitus 4 52.72 Quite High
Hypertension 3 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3A shows a 57% decrease of active RhoC in the HPAF-II/dnRhoC transfectants compared with the untransfected and vector transfected controls.
Negative_regulation (decrease) of HPAF in HPAF-II
1) Confidence 0.57 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
Figure 1C demonstrates that ectopic re-expression of cav-1 to levels similar to that of the BxPC-3 cells significantly decreases HPAF-II migration (890 ± 67 square pixels; p = 0.0032) compared with the untransfected or GFP-vector control HPAF-II cells (1630 ± 183 and 1435 ± 235 square pixels, respectively).
Negative_regulation (decreases) of HPAF in BxPC-3
2) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.12 Pain Relevance 0
PD2i was also found to be a statistically significant predictor of AD in the AMI subgroup (relative-risk = 7.39, p ?
Negative_regulation (predictor) of PD2i associated with death
3) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621378 Disease Relevance 1.12 Pain Relevance 0.35
The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 consistent with the well established role of intracellular calcium in smooth muscle constriction.
Negative_regulation (reduction) of PD2 in smooth muscle
4) Confidence 0.22 Published 1998 Journal Lung Section Abstract Doc Link 9436176 Disease Relevance 0 Pain Relevance 0.21
A cumulative concentration-response curve for R-alpha-methylhistamine was made; when a second curve was made 30 min afterwards, a marked decrease of pD2 and a more modest decrease of Emax were observed without changes in tissue sensitivity to electrical stimulation or morphine inhibition.
Negative_regulation (decrease) of pD2 associated with morphine
5) Confidence 0.09 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543246 Disease Relevance 0 Pain Relevance 0.14
For values of PD2i that lie in the transition zone between 1.6 and 1.4 (the cut-point, ROC area = 0.91)16 very small amounts of low-level noise can falsely increase low PD2i’s into this region; if data files had such transition zone PD2i scores, then a transition zone algorithm (TZA) was applied: if the mean PD2i was highly reduced from normal with >75% of the PD2i’s being below 3.0, then 0.2 degrees of freedom (dimension) was subtracted from each PD2i value.


Negative_regulation (reduced) of PD2i
6) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731023 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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