INT73113

Context Info Confidence 0.70 First Reported 1998 Last Reported 2007 Negated 0 Speculated 2 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 0.78 Pain Relevance 1.32

Anatomy Link Frequency brain 4 cochlea 2 basal ganglia 1 lung 1 prefrontal 1 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dopamine receptor 4 100.00 Glutamate 4 98.12 Nucleus accumbens 8 95.00 Dopamine 7 75.00 potassium channel 6 75.00 gABA 4 75.00 Kinase C 3 67.36 local anesthetic 5 55.72 agonist 3 50.00 MU agonist 1 50.00

Disease Link Frequency Relevance Heat Schizophrenia 8 97.40 Ganglion Cysts 2 76.96 Tinnitus 2 5.00

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Developmental expression of two-pore domain potassium (2P K) channels, TASK-1 and TREK-1, was investigated in the rat cochlea at onset of hearing and after maturity using RT-PCR and immunocytochemistry.

Spec (investigated) Gene_expression (expression) of TREK-1 in cochlea

1) Confidence 0.70 Published 2004 Journal Neuroreport Section Abstract Doc Link 15094499 Disease Relevance 0.06 Pain Relevance 0

Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea.

Gene_expression (expression) of TREK-1 in cochlea

2) Confidence 0.70 Published 2004 Journal Neuroreport Section Title Doc Link 15094499 Disease Relevance 0.08 Pain Relevance 0.06

The salient features of the primary amino acid sequence include four putative transmembrane domains and, unlike other cloned tandem pore domain channels, a PDZ (postsynaptic density protein, disk-large, zo-1) binding sequence at the C terminal. rTASK has distant overall homology to a putative Caenorhabditis elegans K+ channel and to the mammalian clones TREK-1 and TWIK-1. rTASK expression is most abundant in rat heart, lung, and brain.

Gene_expression (expression) of TREK-1 in brain

3) Confidence 0.13 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9437008 Disease Relevance 0 Pain Relevance 0.13

The salient features of the primary amino acid sequence include four putative transmembrane domains and, unlike other cloned tandem pore domain channels, a PDZ (postsynaptic density protein, disk-large, zo-1) binding sequence at the C terminal. rTASK has distant overall homology to a putative Caenorhabditis elegans K+ channel and to the mammalian clones TREK-1 and TWIK-1. rTASK expression is most abundant in rat heart, lung, and brain.

Gene_expression (expression) of TREK-1 in heart

4) Confidence 0.04 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9437008 Disease Relevance 0 Pain Relevance 0.13

The salient features of the primary amino acid sequence include four putative transmembrane domains and, unlike other cloned tandem pore domain channels, a PDZ (postsynaptic density protein, disk-large, zo-1) binding sequence at the C terminal. rTASK has distant overall homology to a putative Caenorhabditis elegans K+ channel and to the mammalian clones TREK-1 and TWIK-1. rTASK expression is most abundant in rat heart, lung, and brain.

Gene_expression (expression) of TREK-1 in lung

5) Confidence 0.04 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9437008 Disease Relevance 0 Pain Relevance 0.13

We used in situ hybridization histochemistry to assess expression of dopamine receptors (D1R, D2R and D3R), neurotensin, proenkephalin and glutamate decarboxylase-67 (GAD67) in the prefrontal cortex, striatum, and/or nucleus accumbens in adult rats with neonatal ventral hippocampal (VH) lesions and in control animals after acute and chronic treatment with antipsychotic drugs clozapine and haloperidol.

Gene_expression (expression) of D1R in prefrontal associated with nucleus accumbens, glutamate and dopamine receptor

6) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.14 Pain Relevance 0.22

Antipsychotic drugs did not alter expression of D1R, D2R or D3R receptor mRNAs but elevated neurotensin and proenkephalin expression in both groups of rats; patterns of changes were dependent on the duration of treatment and brain area examined.

Gene_expression (expression) of D1R in brain

7) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.16 Pain Relevance 0.22

Our results indicate that the neonatal VH lesion did not alter expression of D1R, D3R, neurotensin or proenkephalin expression in any brain region examined.

Gene_expression (expression) of D1R in brain

8) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.17 Pain Relevance 0.22

Our results indicate that the neonatal VH lesion did not alter expression of D1R, D3R, neurotensin or proenkephalin expression in any brain region examined.

Gene_expression (expression) of D1R in brain

9) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.17 Pain Relevance 0.22

MATERIALS AND METHODS: Gene expression of D1 and D2 receptors (D1R and D2R), the DA transporter, as well as the endogenous opioid prodynorphin (DYN), in the basal ganglia was examined by in situ hybridization in rats after one or ten drug injections.

Spec (examined) Gene_expression (expression) of D1R in basal ganglia

10) Confidence 0.01 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17619861 Disease Relevance 0 Pain Relevance 0

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