INT73126

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
cardiac myocytes 2
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 99.00 Very High Very High Very High
Delta opioid receptors 1 98.64 Very High Very High Very High
tolerance 5 96.56 Very High Very High Very High
opioid receptor 4 96.48 Very High Very High Very High
Neurotransmitter 8 92.20 High High
Kappa opioid receptor 1 91.84 High High
Spinal cord 5 88.24 High High
Morphine 4 83.00 Quite High
medulla 4 79.20 Quite High
Enkephalin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 66 92.36 High High
Hypoxia 4 78.12 Quite High
Cognitive Disorder 94 50.00 Quite Low
Increased Venous Pressure Under Development 6 39.16 Quite Low
Disease 24 26.88 Quite Low
Apoptosis 2 12.08 Low Low
Cv General 4 Under Development 24 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypertrophied RV demonstrates increased tissue expression of PDE-5.23 In healthy individuals, PDE-5 is expressed in the coronary arteries, but is not typically found in cardiac myocytes.
Positive_regulation (increased) of Gene_expression (expression) of PDE-5 in cardiac myocytes
1) Confidence 0.59 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.55 Pain Relevance 0
Recently, the cyclic guanosine monophosphate (cGMP) second messenger system receives more and more attention. cGMP is produced by guanylate cyclase (GC) which is stimulated by nitric oxide (NO) (Murad et al. 1978). cGMP activates cGMP-dependent protein kinase (PKG), which in turn phosphorylates certain proteins which influence the synthesis and/or release of other neurotransmitters, and thus signal transduction (Schmidt et al. 1993).
Positive_regulation (stimulated) of Gene_expression (produced) of cGMP associated with neurotransmitter
2) Confidence 0.18 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.05
Since activation of NO increases the production of cGMP, the present results demonstrating alterations of cGMP levels by mu-, kappa- and delta-opioid receptor agonists are consistent with the behavioral results with NOS inhibitors on tolerance to mu-, kappa- and delta-opioid receptor agonists.
Neg (NO) Positive_regulation (increases) of Gene_expression (production) of cGMP associated with tolerance, agonist and opioid receptor
3) Confidence 0.07 Published 1997 Journal Peptides Section Abstract Doc Link 9437726 Disease Relevance 0 Pain Relevance 1.26

General Comments

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