INT73175

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.53
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa1b) mitochondrion (Hspa1b) nucleus (Hspa1b)
intracellular (Hspa1b) protein complex (Hspa1b) response to stress (Hspa1b)
Hspa1b (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 10 99.98 Very High Very High Very High
narcan 4 99.50 Very High Very High Very High
Paracetamol 17 99.36 Very High Very High Very High
Morphine 54 95.40 Very High Very High Very High
cocaine 3 94.00 High High
Ventral tegmentum 5 82.84 Quite High
Locus ceruleus 3 82.52 Quite High
Opioid 23 80.84 Quite High
analgesia 6 69.96 Quite High
opiate 3 67.92 Quite High
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Sprains And Strains 74 98.64 Very High Very High Very High
Injury 1 97.76 Very High Very High Very High
Hepatotoxicity 10 97.64 Very High Very High Very High
Targeted Disruption 9 93.08 High High
Fever 1 88.88 High High
Toxicity 2 72.20 Quite High
Heat Stress Disorders 2 60.56 Quite High
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that increased Hsp70i expression in response to APAP acts to limit the extent of tissue injury.
Positive_regulation (increased) of Gene_expression (expression) of Hsp70i associated with paracetamol and injury
1) Confidence 0.48 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16280147 Disease Relevance 1.52 Pain Relevance 1.00
Naloxone-precipitated withdrawal induced expression of the heat shock protein 1B (Hspa1b).
Positive_regulation (induced) of Gene_expression (expression) of Hspa1b associated with shock, narcan and withdrawal
2) Confidence 0.43 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.55 Pain Relevance 1.30
These results suggest that elevated levels of hsp25 and hsp70i provide protection against acetaminophen and bromobenzene hepatotoxicity.
Positive_regulation (elevated) of Gene_expression (levels) of hsp70i associated with paracetamol and hepatotoxicity
3) Confidence 0.06 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.47 Pain Relevance 0.42

General Comments

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