INT73176

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.96
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Hspd1) cytosol (Hspd1) mitochondrion (Hspd1)
extracellular space (Hspd1) Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
plasma 1
body 1
Hspd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 19 99.04 Very High Very High Very High
tolerance 18 88.44 High High
cocaine 2 80.16 Quite High
cytokine 18 33.92 Quite Low
Inflammation 10 25.00 Low Low
chemokine 10 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 162 97.40 Very High Very High Very High
Hepatotoxicity 4 94.80 High High
Disease 27 93.12 High High
Metastasis 92 91.96 High High
Skin Cancer 16 91.44 High High
Shock 11 88.48 High High
Toxicity 1 84.56 Quite High
Death 26 80.16 Quite High
Injury 5 78.40 Quite High
Infection 15 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, HSP60 activation of TLR2 mediates the expression and phosphorylation of Stat3 in tumor cells.
Positive_regulation (activation) of HSP60 associated with cancer
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.73 Pain Relevance 0.04
Targeting TLR2, including TLR2pre, TLR2aft or TLR2KD-B16, significantly reduced the enhanced HSP60 in BALF of B16-bearing mice, but targeting TLR4 did not (Fig. 3E).
Positive_regulation (enhanced) of HSP60
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.89 Pain Relevance 0
Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90).
Neg (no) Positive_regulation (induction) of hsp60 in body
3) Confidence 0.29 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.48 Pain Relevance 0.20
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Spec (examined) Positive_regulation (following) of HSP60 in plasma associated with paracetamol
4) Confidence 0.15 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.98
This hypothesis is based on the finding that the cpn60 gene is up-regulated in response to hydrogen peroxide, a source of oxygen radicals.
Positive_regulation (up) of cpn60
5) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2621373 Disease Relevance 0.52 Pain Relevance 0
This hypothesis is based on the finding that the cpn60 gene is up-regulated in response to hydrogen peroxide, a source of oxygen radicals.
Positive_regulation (-) of cpn60
6) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2621373 Disease Relevance 0.52 Pain Relevance 0
This hypothesis is based on the finding that the cpn60 gene is up-regulated in response to hydrogen peroxide, a source of oxygen radicals.
Positive_regulation (regulated) of cpn60
7) Confidence 0.08 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2621373 Disease Relevance 0.52 Pain Relevance 0

General Comments

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