INT73178

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.70
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1)
ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)
Anatomy Link Frequency
cartilage 1
body 1
Hsp90aa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 93.36 High High
cocaine 2 81.52 Quite High
cytokine 5 50.00 Quite Low
Osteoarthritis 4 50.00 Quite Low
addiction 4 50.00 Quite Low
Calcium channel 7 10.48 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 96.16 Very High Very High Very High
Toxicity 2 85.92 High High
Shock 155 82.04 Quite High
Apoptosis 2 75.28 Quite High
Osteoarthritis 5 75.04 Quite High
Lysosomal Storage Diseases 24 50.00 Quite Low
Sprains And Strains 11 44.44 Quite Low
Stress 25 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Gauchers Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, induction of Hsp90 and other family members may dampen the PPAR?
Positive_regulation (induction) of Hsp90
1) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.14 Pain Relevance 0
RESULTS: The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-gamma were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1 beta remained unchanged.
Positive_regulation (up-regulated) of HSP86 in cartilage
2) Confidence 0.41 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.08 Pain Relevance 0
Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90).
Neg (no) Positive_regulation (induction) of hsp90 in body
3) Confidence 0.32 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.48 Pain Relevance 0.21
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Positive_regulation (increased) of Hsp90
4) Confidence 0.24 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

General Comments

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