INT73179

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Context Info
Confidence 0.73
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.24
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa1b) mitochondrion (Hspa1b) nucleus (Hspa1b)
intracellular (Hspa1b) protein complex (Hspa1b) response to stress (Hspa1b)
Anatomy Link Frequency
plasma 1
livers 1
Hspa1b (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 398 99.92 Very High Very High Very High
withdrawal 28 99.82 Very High Very High Very High
Paracetamol 47 99.36 Very High Very High Very High
narcan 14 99.34 Very High Very High Very High
alcohol 76 98.08 Very High Very High Very High
cocaine 13 93.64 High High
tolerance 81 86.60 High High
Ventral tegmentum 7 82.52 Quite High
Locus ceruleus 5 82.20 Quite High
Opioid 79 80.52 Quite High
Disease Link Frequency Relevance Heat
Shock 40 100.00 Very High Very High Very High
Sprains And Strains 242 98.24 Very High Very High Very High
Injury 6 97.76 Very High Very High Very High
Hepatotoxicity 10 97.64 Very High Very High Very High
Toxicity 4 94.36 High High
Targeted Disruption 14 92.68 High High
Stress 19 92.00 High High
Fever 1 88.48 High High
Neuropathic Pain 24 82.00 Quite High
Hypersensitivity 5 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Hspa1b was highly correlated with mRNA levels of other heat shock proteins, namely heat shock protein 72 (Hspa1a) and heat shock protein 40 (Dnajb1).
Gene_expression (Expression) of Hspa1b associated with shock
1) Confidence 0.73 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.81 Pain Relevance 0.44
The use of HSP70-deficient mice to confirm involvement of this protein in the mechanism of action of KU-32 (Figure 6 in Urban et al., 2010) is elegant and the authors note that extension of mechanistic studies, particularly to identify the downstream consequences of HSP70 induction and the cell types in which it occurs after systemic administration of KU-32, will provide valuable information.
Gene_expression (induction) of HSP70
2) Confidence 0.65 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 0.72 Pain Relevance 0.18
The use of HSP70-deficient mice to confirm involvement of this protein in the mechanism of action of KU-32 (Figure 6 in Urban et al., 2010) is elegant and the authors note that extension of mechanistic studies, particularly to identify the downstream consequences of HSP70 induction and the cell types in which it occurs after systemic administration of KU-32, will provide valuable information.
Gene_expression (use) of HSP70
3) Confidence 0.65 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 0.65 Pain Relevance 0.19
PCR products of five heat-shock proteins (HSP70-1, HSP70-2, HSP70-3, Hsc70 and HSC70t) were produced in-house and added to the library, to produce a final total of 950 unique gene PCR products.


Gene_expression (products) of HSP70-1 associated with shock
4) Confidence 0.65 Published 2001 Journal Genome Biol Section Body Doc Link PMC31483 Disease Relevance 0.18 Pain Relevance 0
The hs-dCREB2b transgene expresses a dCREB2b cDNA from a hsp70 promoter [54].


Gene_expression (expresses) of hsp70
5) Confidence 0.65 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020501 Disease Relevance 0.13 Pain Relevance 0.30
Significant interaction was detected for Sgk, Nfkbia, and Hspa1b, for example (Additional data file 1).
Gene_expression (detected) of Hspa1b
6) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.61 Pain Relevance 0.60
Naloxone-precipitated withdrawal induced expression of the heat shock protein 1B (Hspa1b).
Gene_expression (expression) of Hspa1b associated with shock, narcan and withdrawal
7) Confidence 0.55 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.55 Pain Relevance 1.29
These observations suggest that increased Hsp70i expression in response to APAP acts to limit the extent of tissue injury.
Gene_expression (expression) of Hsp70i associated with paracetamol and injury
8) Confidence 0.54 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16280147 Disease Relevance 1.51 Pain Relevance 1.00
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Gene_expression (levels) of HSP70i in plasma associated with paracetamol
9) Confidence 0.12 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.92
The aim of the present study was to assess the contribution of the level of expression of heat shock protein 25 (HSP25), 60 (HSP60), 70 (HSC70) and 70i (HSP70i) in mouse livers after a lethal dose of acetaminophen (APAP) to their survival.
Gene_expression (expression) of HSP70i in livers associated with paracetamol and shock
10) Confidence 0.08 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.31 Pain Relevance 0.69
These results suggest that elevated levels of hsp25 and hsp70i provide protection against acetaminophen and bromobenzene hepatotoxicity.
Gene_expression (levels) of hsp70i associated with paracetamol and hepatotoxicity
11) Confidence 0.07 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.47 Pain Relevance 0.42

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