INT73181

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 29
Disease Relevance 15.84
Pain Relevance 7.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
livers 2
B cells 2
plasma 1
Mouse 1
temporomandibular joint 1
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 95 99.32 Very High Very High Very High
Inflammatory response 7 98.66 Very High Very High Very High
Snapping jaw 12 98.44 Very High Very High Very High
Inflammation 101 97.40 Very High Very High Very High
cocaine 2 93.64 High High
fibrosis 30 86.48 High High
interstitial cystitis 1 80.48 Quite High
anesthesia 29 61.28 Quite High
addiction 2 50.00 Quite Low
corticosteroid 6 33.72 Quite Low
Disease Link Frequency Relevance Heat
Shock 300 100.00 Very High Very High Very High
Apoptosis 159 99.98 Very High Very High Very High
Targeted Disruption 660 99.52 Very High Very High Very High
Alzheimer's Dementia 198 98.84 Very High Very High Very High
Renal Disease 195 98.84 Very High Very High Very High
INFLAMMATION 113 98.48 Very High Very High Very High
Temporomandibular Joint Syndrome 12 98.44 Very High Very High Very High
Death 100 98.04 Very High Very High Very High
Coronary Heart Disease 180 97.60 Very High Very High Very High
Hepatotoxicity 5 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of 25 kDa heat shock protein by synovial type B cells of the mouse temporomandibular joint.
Gene_expression (Expression) of 25 kDa heat shock protein in B cells associated with snapping jaw and shock
1) Confidence 0.78 Published 2001 Journal Arch. Oral Biol. Section Title Doc Link 11451409 Disease Relevance 0.46 Pain Relevance 0.27
For these reasons, the expression of Hsp25 was investigated in the synovial membrane of the mouse temporomandibular joint by immunocytochemistry and by in situ hybridization using a specific cRNA probe.
Gene_expression (expression) of Hsp25 in temporomandibular joint associated with snapping jaw
2) Confidence 0.78 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11451409 Disease Relevance 0.42 Pain Relevance 0.26
Notably, the survival ratio dropped by only 2% after HSP25 expression.
Gene_expression (expression) of HSP25
3) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.55 Pain Relevance 1.20
In contrast, HSP25 could be detected just 24 h after APAP treatment, and maximal accumulation was observed at 48 h.
Gene_expression (detected) of HSP25 associated with paracetamol
4) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.52 Pain Relevance 1.25
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Gene_expression (levels) of HSP25 in plasma associated with paracetamol
5) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.92
In the present study, we show that geranylgeranylacetone (GGA), a nontoxic antiulcer drug and inducer of small HSPs [16], can induce expression of HSPB8 and HSPB1 and reduce the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
Gene_expression (expression) of HSPB1 associated with targeted disruption and alzheimer's dementia
6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.43 Pain Relevance 0.04
In situ hybridization showed intense signals for Hsp25 mRNA in the synovial lining cells, suggesting that the type B cells produce, rather than resorb, Hsp25.
Gene_expression (produce) of Hsp25 in B cells
7) Confidence 0.68 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11451409 Disease Relevance 0.43 Pain Relevance 0.30
(40), Hsp25, Hsp70, Hsp86, Hsp110 but not Hsp65 were observed in wild-type mice after HS; the increases in all of the proteins were PPAR?
Gene_expression (observed) of Hsp25 associated with shock
8) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.68 Pain Relevance 0
The aim of the present study was to assess the contribution of the level of expression of heat shock protein 25 (HSP25), 60 (HSP60), 70 (HSC70) and 70i (HSP70i) in mouse livers after a lethal dose of acetaminophen (APAP) to their survival.
Gene_expression (expression) of heat shock protein 25 in livers associated with paracetamol and shock
9) Confidence 0.60 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.30 Pain Relevance 0.62
The aim of the present study was to assess the contribution of the level of expression of heat shock protein 25 (HSP25), 60 (HSP60), 70 (HSC70) and 70i (HSP70i) in mouse livers after a lethal dose of acetaminophen (APAP) to their survival.
Gene_expression (expression) of HSP25 in livers associated with paracetamol and shock
10) Confidence 0.60 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.30 Pain Relevance 0.62
Taken together, the level of expression of hepatic HSP25 may be a crucial determinant of the fate of mice exposed to APAP insult.
Gene_expression (expression) of HSP25 associated with paracetamol
11) Confidence 0.60 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.50 Pain Relevance 0.97
Although the expression levels of HSPB5 in the WT and R120G hearts were similar, HSPB8, HSPB1 and HSP70 were up-regulated in the hearts from R120G TG mice as compared with those of HSPB5 WT TG and NTG mice (Figure 2A and B).
Gene_expression (expression) of HSPB1 in hearts associated with targeted disruption
12) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.73 Pain Relevance 0
There were no differences in HSPB8, HSPB1 and HSP70 levels between WT TG and NTG mice, although HSPB5 was overexpressed in WT TG mice (Figure 2A and B).
Gene_expression (levels) of HSPB1 associated with targeted disruption
13) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.72 Pain Relevance 0
The anti-apoptotic activities of phosphorylated HSP25/27 in cells exposed to TNF?
Gene_expression (activities) of HSP25 associated with apoptosis
14) Confidence 0.59 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.96 Pain Relevance 0
M) stimulated total HSP25 protein expression the most (data not shown) and was therefore used for all subsequent experiments.
Gene_expression (expression) of HSP25 protein
15) Confidence 0.59 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
In other studies in vitro, direct binding of HSP25/27 to the upstream regulator of NF?
Gene_expression (direct) of HSP25
16) Confidence 0.59 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.20 Pain Relevance 0
Membranes were probed with the following antibodies: HSP25 (Stressgen, Victoria, BC, Canada), total p38MAPK, phospho-p38MAPK and cleaved caspase-3 (Cell Signaling Technology, Inc.
Gene_expression (antibodies) of HSP25
17) Confidence 0.59 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
A time-dependent titration further demonstrated that treating cells with Cur for 60-70 min stimulated HSP25 protein expression (data not shown).
Gene_expression (expression) of HSP25 protein
18) Confidence 0.59 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
While GGA increased the expression levels of HSPB8 and HSPB1 as well as HSP70 in a dose-dependent manner, no induction of HSPB5 was observed (Figure 1A and B).
Gene_expression (expression) of HSPB1
19) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.44 Pain Relevance 0
While GGA increased the expression levels of HSPB8 and HSPB1 as well as HSP70 in a dose-dependent manner, no induction of HSPB5 was observed (Figure 1A and B).
Gene_expression (levels) of HSPB1
20) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.44 Pain Relevance 0

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