INT73199

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.42
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K7) signal transduction (MAP3K7) plasma membrane (MAP3K7)
kinase activity (MAP3K7) response to stress (MAP3K7) cytoplasm (MAP3K7)
MAP3K7 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 74.56 Quite High
Inflammation 10 23.92 Low Low
agonist 13 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 10 99.66 Very High Very High Very High
Cancer 18 98.60 Very High Very High Very High
Apoptosis 1 82.60 Quite High
Brain Tumor 2 75.00 Quite High
Malignant Neoplastic Disease 2 67.60 Quite High
INFLAMMATION 12 23.92 Low Low
Disease 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with both glioma cell lines and primary tumor tissues have strongly suggested that TGF-alpha and EGFR function as an important autocrine loop in supporting proliferation of human glioma, especially in high grade glioma, since elevated TGF-alpha expression is also found in these high grade tumors.
Gene_expression (expression) of TGF-alpha associated with cancer and glioma
1) Confidence 0.26 Published 1997 Journal J. Neurooncol. Section Abstract Doc Link 9440027 Disease Relevance 1.18 Pain Relevance 0.07
Furthermore, down regulation of the expression of TGF-alpha by antisense constructs has been shown to inhibit several types of human tumor cell growth including glioma.
Gene_expression (expression) of TGF-alpha associated with cancer and glioma
2) Confidence 0.26 Published 1997 Journal J. Neurooncol. Section Abstract Doc Link 9440027 Disease Relevance 1.15 Pain Relevance 0.07
This is likely to be at the level of TRAFs or MEKKs such as TAK1 or ASK1, however this will be difficult to decipher as less is known about TRAF mediated activation of the p38 MAPK pathway [46].
Gene_expression (level) of TAK1
3) Confidence 0.16 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.08 Pain Relevance 0

General Comments

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