INT73200

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 9.67
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
platelet 3
fibroblasts 1
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 55 98.64 Very High Very High Very High
Bioavailability 1 96.96 Very High Very High Very High
Central nervous system 2 94.92 High High
palliative 6 90.32 High High
Potency 11 56.88 Quite High
abdominal pain 2 25.00 Low Low
headache 1 25.00 Low Low
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 202 99.70 Very High Very High Very High
Cancer 208 99.44 Very High Very High Very High
Pancreatic Cancer 211 99.34 Very High Very High Very High
Fibrosis 50 98.64 Very High Very High Very High
Myeloid Leukemia 8 97.08 Very High Very High Very High
Leukemia 4 95.84 Very High Very High Very High
Hypereosinophilic Syndrome 5 95.80 Very High Very High Very High
Metastasis 28 95.44 Very High Very High Very High
Solid Tumor 30 94.64 High High
Colon Cancer 5 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular analysis demonstrated a constitutive activation of the platelet-derived growth factor receptor-alpha (PDGFR-A) as the mechanism of responsiveness to imatinib.
Positive_regulation (activation) of PDGFR in platelet
1) Confidence 0.67 Published 2004 Journal Ann. Hematol. Section Abstract Doc Link 14986065 Disease Relevance 0.60 Pain Relevance 0.05
More importantly, for the ultimate goal of treating or preventing fibrosis in patients, we found that SU9518 attenuated the radiation-induced upregulation of PDGFR.
Positive_regulation (upregulation) of PDGFR associated with fibrosis
2) Confidence 0.64 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.53 Pain Relevance 0.12
Although the ultimate mechanism of PDGFR overexpression remains unclear, we found ionizing radiation can upregulate PDGFR in fibroblasts.
Positive_regulation (upregulate) of PDGFR in fibroblasts
3) Confidence 0.56 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.58 Pain Relevance 0.12
Imatinib causes PDGFR ?
Positive_regulation (causes) of PDGFR
4) Confidence 0.51 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.10 Pain Relevance 0
Activation of PDGFR leads to downstream signal transduction via PI-3K, Phospholipase C?
Positive_regulation (Activation) of PDGFR
5) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.44 Pain Relevance 0.03
Among the genetic alternations found in these tumors, p53 inactivation and PDGF/PDGFR activation represent the early events, and the loss of chromosome 10 and gene amplification and rearrangement of EGFR represent the late events.
Positive_regulation (activation) of PDGFR associated with cancer
6) Confidence 0.45 Published 1997 Journal J. Neurooncol. Section Abstract Doc Link 9440027 Disease Relevance 1.11 Pain Relevance 0.09
Besides abl and bcr-abl, imatinib also inhibits the activation of PDGFR ?
Positive_regulation (activation) of PDGFR
7) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.03 Pain Relevance 0
In murine breast tumours inhibition of activated PDGFR ß by imatinib leads to reduction in tumour cell growth [20].
Positive_regulation (activated) of PDGFR associated with cancer and breast cancer
8) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.37 Pain Relevance 0
Platelet-derived growth factor ligands, PDGF-A and PDGF-B, exert their effects on target cells by activating the two structurally related protein tyrosine kinase receptors, PDGFR-?
Positive_regulation (activating) of PDGFR in Platelet
9) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.50 Pain Relevance 0.03
In our study we could demonstrate that imatinib is able to inhibit the autocrine and paracrine mediated activation of the PDGFR ?
Positive_regulation (activation) of PDGFR
10) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.60 Pain Relevance 0
Ebert et al demonstrated that pancreatic tumor samples exhibited a significant increase in PDGFR-?
Positive_regulation (increase) of PDGFR associated with pancreatic cancer
11) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.12 Pain Relevance 0
In vitro studies with various tumor cell lines have shown that the antiangiogenic effects of sunitinib are mediated through VEGFR and PDGFR.
Positive_regulation (mediated) of PDGFR associated with cancer
12) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 0.84 Pain Relevance 0.05
The bi-aryl urea sorafenib is an oral multikinase inhibitor that inhibits cell surface tyrosine kinase receptors (e.g. vascular endothelial growth factor receptors and platelet-derived growth factor receptor-beta) and downstream intracellular serine/threonine kinases (e.g.
Positive_regulation (derived) of growth factor receptor-beta in platelet
13) Confidence 0.07 Published 2009 Journal Drugs Section Abstract Doc Link 19228077 Disease Relevance 0.86 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox