INT73202

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Context Info
Confidence 0.23
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.37
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K7) signal transduction (MAP3K7) plasma membrane (MAP3K7)
kinase activity (MAP3K7) response to stress (MAP3K7) cytoplasm (MAP3K7)
MAP3K7 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 74.92 Quite High
Disease Link Frequency Relevance Heat
Glioma 10 99.84 Very High Very High Very High
Cancer 16 98.60 Very High Very High Very High
Brain Tumor 2 75.00 Quite High
Malignant Neoplastic Disease 2 67.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with both glioma cell lines and primary tumor tissues have strongly suggested that TGF-alpha and EGFR function as an important autocrine loop in supporting proliferation of human glioma, especially in high grade glioma, since elevated TGF-alpha expression is also found in these high grade tumors.
Positive_regulation (elevated) of Gene_expression (expression) of TGF-alpha associated with cancer and glioma
1) Confidence 0.23 Published 1997 Journal J. Neurooncol. Section Abstract Doc Link 9440027 Disease Relevance 1.18 Pain Relevance 0.07
Studies with both glioma cell lines and primary tumor tissues have strongly suggested that TGF-alpha and EGFR function as an important autocrine loop in supporting proliferation of human glioma, especially in high grade glioma, since elevated TGF-alpha expression is also found in these high grade tumors.
Positive_regulation (elevated) of Gene_expression (expression) of TGF-alpha associated with cancer and glioma
2) Confidence 0.17 Published 1997 Journal J. Neurooncol. Section Abstract Doc Link 9440027 Disease Relevance 1.18 Pain Relevance 0.07

General Comments

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